// Peisong Wang 1 , Xianying Meng Yan Huang 2 Zhi Lv Jia Liu Guimin Wei Shuai Xue Qiang Zhang Pengju 3, * Guang Chen 1, Department of Thyroid Surgery, The First Hospital Jilin University, Chaoyang District, Changchun 130021, China Orthopaedic China-Japan Union Jingyue 130033, 3 Academy Agricultural Sciences, Nanguan 130000, These authors have contributed equally to this work Correspondence to: Chen, email: chenguang518@aliyun.com Zhang, pengju213@126.com Keywords: miR-497, thyroid cancer,...

As the most common endocrine malignancy with a high incidence, thyroid cancer lacks dual-modal imaging method for precise diagnosis. An accurate and multimodal system is pivotal to solve this problem. Herein, dual-modality fluorescence/Computed Tomography (CT) iodinated gold nanoclusters malignant visualization have been recently fabricated. In study, innovative (AuNCs@BSA-I) were synthesized via Bovine serum albumin (BSA) chloramine-T. AuNCs@BSA-I not only possess an ultra-small size...

Non-alcoholic fatty liver disease (NAFLD) is a chronic characterised by lipid deposition in cells. The global prevalence of NAFLD has significantly increased from 8.2% 1990 to 30.2% 2023, establishing it as growing public health concern. In recent years, the name been replaced metabolic dysfunction-associated (MASLD). Numerous observational studies have investigated potential association between hypothyroidism and MASLD; however, findings remain inconsistent. this context, systematic...

This prospective study aimed to analyze the efficacy and safety of fine-needle prick (FNP) in assessment parathyroid gland (PG) perfusion during thyroid surgery. A total 147 patients with papillary carcinoma (PTC) who underwent lobectomy therapeutic unilateral central lymph node dissection (CLND) performed by same surgeon at First Hospital Jilin University between June September 2024 were included this study. Following removal nodes, indocyanine green (ICG) was prepared administered...

The objective of the study was to assess patterns central cervical lymph node metastasis (CLNM) and evaluate prophylactic dissection (CLND) in papillary thyroid carcinoma (PTC) patients without clinical positive nodes.We retrospectively reviewed 1555 with PTC between 2003 2008. Lymph metastatic risk factors pattern were studied using multivariate analysis.Male patients, aged ≤ 45 years, presence extrathyroidal extension, a primary tumor size > 10 mm identified as for CLNM odds ratios 2.089,...

Long intergenic non‐coding RNA 152 (LINC00152) was reported to be tightly linked tumorigenesis and progression in multiple cancers. However, its biological role modulatory mechanism papillary thyroid carcinoma (PTC) has not been elucidated. In this study, we determined the expression levels of LINC00152 PTC tissues cell lines by quantitative real time polymerase chain reaction (qRT‐PCR). Cell proliferation, colony formation, migration, invasion were measured a Counting Kit‐8 assay, formation...

Abstract The multi-system involvement and high heterogeneity of systemic lupus erythematosus (SLE) pose great challenges to its diagnosis treatment. purpose the current study is identify genes pathways involved in pathogenesis SLE. High throughput sequencing was performed on PBMCs from SLE patients. We conducted differential gene analysis, ontology (GO) kyoto encyclopedia genomes (KEGG) quantitative real-time PCR (qRT-PCR) verification. Protein–protein interaction (PPI) alternative splicing...

The extent of surgery in patients with unilateral multifocal papillary thyroid microcarcinoma (UMPTMC) remains to be controversial. Aimed improve surgical management UMPTMC, this study was performed identify the recurrence UMPTMC and analyze its predictive factors.This approved by Ethical Committee First Hospital Jilin University, written informed consent given participants for their clinical records used study. We retrospectively analyzed a total 97 consecutive who underwent initial...

Objective The aim of this study was to explore the relationships between expression NIN1/RPN12 binding protein 1 homologue gene ( NOB1) in papillary thyroid carcinoma tissue and clinicopathological variables. Methods Expression NOB1 carcinoma, normal benign tumour evaluated at mRNA levels by real-time fluorescence quantitative reverse transcription–polymerase chain reaction immunohistochemistry, respectively. Relationships immunohistochemical scores several variables were also examined....

Whether we should use carbon nanoparticle (CN) routinely in thyroid surgery is still controversial. 406 papillary cancer (PTC) patients who underwent total thyroidectomy (TT) with bilateral central lymph node dissection (CLND) from January 2010 to December 2012 were retrospectively analyzed. The incidence of transient hypoparathyroidism and hypocalcemia CN group was significantly lower than the control at second, fifth day after (P = 0.004, 0.042, 0.002 0.045 respectively). However, no...

Objective Active surveillance (AS) has been recommended as the first-line treatment strategy for low-risk (LR) papillary thyroid microcarcinoma (PTMC) according to guidelines. However, preoperative imaging and fine-needle aspiration could not rule out a small group of patients with aggressive PTMC large-volume lymph node micro-metastasis, extrathryoidal invasion surrounding soft tissue, or high-grade malignancy from AS candidates. Methods Among 2,809 patients, 2,473 were enrolled in this...

Objectives To examine expression of the connective tissue growth factor ( CTGF) gene in human thyroid cancer and establish whether a correlation exists between presence CTGF protein clinicopathological parameters disease. Methods was investigated retrospectively by immunohistochemical analysis levels tumour tissue. Associations score several were examined. Results In total, 131 specimens included. High observed papillary carcinoma tissue; benign scored negatively for protein. carcinoma,...

Nanoparticles were prepared from amphiphilic glycyrrhetinic acid–porphyrin conjugates (TPP–GA) and applied for the photodynamic therapy of cancer.

Solitary papillary thyroid microcarcinoma (PTMC) without gross extrathyroidal extension (ETE) were the main candidates for active surveillance (AS). Predictive factors of lateral lymph node metastasis (LLNM) in solitary PTMC ETE essential but still unknown.Altogether, 171 patients enrolled our study and divided into two groups. Group A: 123 dissection (LLND) considered to be LLNM negative because there was no recurrence by at least 8-year follow up all patients. B: 48 with LLND positive...

Abstract Introduction We aimed to carry out a retrospective study from single institution determine whether radioactive iodine (RAI) ablation decreases the risk of recurrence papillary thyroid microcarcinoma (PTMC) patients that presented with lateral lymph node metastasis (LLNM). Methods retrospectively analyzed total 6361 consecutive PTMC who initially underwent surgery for treatment carcinoma at First Hospital Jilin University, between January 2005 and February 2015. Altogether, 137 LLNM...

Transaxillary endoscopic thyroidectomy (TAET) is favored for its favorable cosmetic outcomes and the preservation of anterior cervical function. Despite these benefits, postoperative analgesia has traditionally relied on pharmacological interventions, regional anesthetic procedures may be an alternative method. This study aimed to evaluate efficacy ultrasound-guided pectoserratus plane block (PSPB) combined with intermediate plexus (ICPB) TAET.