A5101529083- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Extracellular vesicles in disease
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Renal Transplantation Outcomes and Treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer Mechanisms and Therapy
- Pediatric health and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- Renin-Angiotensin System Studies
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Mechanisms of cancer metastasis
- Ovarian cancer diagnosis and treatment
- Hedgehog Signaling Pathway Studies
- interferon and immune responses
Fudan University
2013-2024
Taixing People's Hospital
2017-2023
Shanghai Jiao Tong University
2010-2021
Shanghai Mental Health Center
2021
Shanghai Children's Hospital
2021
Shanghai Ninth People's Hospital
2004-2020
First Affiliated Hospital of Shihezi University Medical College
2019
Nanyang Institute of Technology
2017
Beijing Hospital
2017
Linyi People's Hospital
2016
Fourteen volatile organic compound (VOC) biomarkers in the breath have been identified to distinguish early gastric cancer (EGC) and advanced (AGC) patients from healthy persons by gas chromatography–mass spectrometry coupled with solid phase microextraction (SPME). Then, a analysis approach based on surface-enhanced Raman scattering (SERS) sensor was developed detect these biomarkers. Utilizing hydrazine vapor adsorbed graphene oxide (GO) film, clean SERS is facilely prepared situ formation...
Recently, video object segmentation (VOS) referred by multi-modal signals, e.g., language and audio, has evoked increasing attention in both industry academia. It is challenging for exploring the semantic alignment within modalities visual correspondence across frames. However, existing methods adopt separate network architectures different modalities, neglect inter-frame temporal interaction with references. In this paper, we propose MUTR, a Multi-modal Unified Temporal transformer...
Patients with pancreatic cancer (PC) are usually diagnosed at late stages, when the disease is nearly incurable. Sensitive and specific markers critical for supporting diagnostic therapeutic strategies. The aim of this study was to use a metabonomics approach identify potential plasma biomarkers that can be further developed early detection PC. In study, metabolites newly PC patients (n = 100) age- gender-matched controls from Connecticut (CT), USA, same number cases Shanghai (SH), China,...
Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including molecules, growth factors, chemokines, and exosomes. MicroRNAs (miRNAs) derived from MSC exosomes (MSCs-Exo) play a critical role regulation immune responses. However, function miRNAs aGvHD remains unknown. Here, we performed expression profiling exosome-miRNAs human umbilical cord MSCs...
<i>Objective:</i> To investigate the expression of special AT-rich sequence-binding protein 1 (SATB1), and relationship between SATB1 clinicopathological factors laryngeal squamous cell carcinoma (LSCC). <i>Methods:</i> Real-time PCR, Western blot immunohistochemistry were used to analyze 80 samples LSCC 25 control mucosa. The parameters was evaluated. <i>Results:</i> mRNA levels in 2.5- 7.5-fold higher than those mucosa tissues (p < 0.001). detected...
Berberine (BBR) is a material extracted from Chinese herbs, which has been used in the treatment of diabetes medicine for thousands years. However, importance BBR renal fibrosis remains to be elucidated. In present study, streptozotocin‑induced diabetic nephropathy (DN) rats were determine effect on fibrosis. The pathology kidneys was examined using periodic acid‑Schiff (PAS) and Masson staining. expression levels transforming growth factor‑β (TGF‑β) α smooth muscle actin (α‑SMA) observed...
Background and Objectives miR-301a is significantly overexpressed in many cancers. However, its expression biological role gastric cancer remain poorly understood. We investigated microRNA-301a (miR-301a) determined effects on cell behavior clinical significance the development progression of cancer. Methods tumors lines by reverse transcription-polymerase chain reaction. The clone formation, migration, invasion HGC-27 SGC-7901 cells were detected following transfection an inhibitor. a...
The abnormal trafficking of CD34+ cells is a unique characteristic primary myelofibrosis (PMF). We have further studied the behavior PMF by examining their homing to marrow and spleens nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Following infusion normal granulocyte colony-stimulating factor-mobilized peripheral blood (mPB) into NOD/SCID mice, reduced numbers granulocyte-macrophage colony-forming unit (CFU-GM) compared with mPB were detected in these whereas similar...
Objective The aim of this study was to explore the relationships between expression NIN1/RPN12 binding protein 1 homologue gene ( NOB1) in papillary thyroid carcinoma tissue and clinicopathological variables. Methods Expression NOB1 carcinoma, normal benign tumour evaluated at mRNA levels by real-time fluorescence quantitative reverse transcription–polymerase chain reaction immunohistochemistry, respectively. Relationships immunohistochemical scores several variables were also examined....
Recent evidence has shown that CD4+ T helper (Th) cells are involved in renal inflammation and fibrosis. However, whether fibrosis can be alleviated by intervening the polarization of remains unknown. Our research investigated effects intravenously administered placenta mesenchymal stromal (PMSCs) or treatment with extracellular EVs (EVs) derived from PMSCs (PMSC-EVs) on rats unilateral ureteral obstruction (UUO). We further verified how affect inflammatory factor secretion levels regulatory...
Hepatocellular carcinoma (HCC) is one of the most life‑threatening diseases in world. Members GTPase immunity‑associated protein (GIMAP) family are important regulating apoptosis cancer cells. However, basic mechanism GIMAP HCC remains to be fully elucidated. The present study was performed investigate dysregulation members HCC. techniques polymerase chain reaction analysis, immunohistochemistry and ELISA were used analyze expression GIMAP5 GIMAP6 tissues, matched noncancerous tissue...
Abstract To analyze the level and diagnostic value of plasmacytoma variant translocation 1 (PVT1) in gastric cancer (GC) Han Uygur Xinjiang, China, we collected 42 GC 47 normal tissues performed tissue microarray. In situ hybridization was used to detect PVT1, while immunohistochemistry c-myc. The relationship between c-myc clinical pathological features investigated. We then analyzed expression PVT1 six cell lines. RNA interference silence BGC823 AGS cells. detected by western blotting...
Mitofusin-2 (MFN2) was initially identified as a hyperplasia suppressor in hyper-proliferative vascular smooth muscle cells (VSMCs) of hypertensive rat arteries, which has also been implicated various cancers. There exists controversy whether it is an oncogene or exerting anti-proliferative effect on tumor cells. Our previous cell cycle analysis and MTT assay showed that proliferation inhibited MFN2 deficient A549 human lung adenocarcinoma cells, without investigating the changes regulatory...
: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP). This study aimed to investigate effect NSAIDs on inflammation and fibrosis progression trinitrobenzene sulfonic acid-induced CP rats.Chronic was induced by acid infusion into rat pancreatic ducts. Naproxen (20 40 mg/kg per os [PO] intraperitoneally) started 2 weeks after induction 3 weeks. Histological analysis pancreas, Van Gieson staining, contents hydroxyproline...
The roles of Wnt protein in carcinogenesis have been well documented human cancers. Wls is a key modulator for the secretion protein. We previously found that was aberrantly expressed colorectal carcinomas. Studies revealed dysregulation signal transduction plays an important role gastric carcinoma. hypothesized may play development and progression In this study, three cancer cell lines MGC‐803, SGC‐7901, AGS, set carcinoma tissue specimens were subjected to immunohistochemistry....