A5101619826- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Hormonal and reproductive studies
- Protease and Inhibitor Mechanisms
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Plant Molecular Biology Research
- Urinary Bladder and Prostate Research
- Research in Cotton Cultivation
- Cell death mechanisms and regulation
- Pediatric Urology and Nephrology Studies
- Cancer-related gene regulation
- Acute Lymphoblastic Leukemia research
- Urological Disorders and Treatments
- Genetic factors in colorectal cancer
- Plant tissue culture and regeneration
- Blood Coagulation and Thrombosis Mechanisms
Jiangnan University
2019-2024
Wuxi Fourth People's Hospital
2019-2024
Nanjing Agricultural University
2020-2023
Qingdao Agricultural University
2023
First Hospital of Jilin University
2023
Jilin University
2023
Zhejiang Provincial People's Hospital
2019-2021
Hangzhou Medical College
2021
Dalian Ocean University
2018
Wuxi Third People's Hospital
2007-2017
The prognosis and overall survival of castration-resistant prostate cancer (CRPC) patients are poor. search for novel efficient anti-CRPC agents is therefore extremely important. WM-3835 a cell-permeable, potent first-in-class HBO1 (KAT7 or MYST2) inhibitor. Here in primary human cells-derived from CRPC patients, potently inhibited cell viability, proliferation, cycle progression vitro migration. inhibitor provoked apoptosis the cells. It failed to induce significant cytotoxicity epithelial...
Increasing study have found that stem cell transplantation a therapeutical effect to diabetes mellitus (DM)-induced erectile dysfunction (ED). So, the aim of this was evaluate beneficial corin from adipose-derived cells (ADSCs) on DM-induced ED.Exosomes were isolated ADSCs (ADSC-EXOs) or in which gene expression silenced by siRNA (siCorin). For vivo studies, rats with streptozotocin-induced DM intravenously injected ADSC-EXOs siCorin-ADSC-EXOs. Two weeks later, intracavernosal pressure (ICP)...
The correlation between superoxide dismutase 2 (SOD2) V16A variant and urological cancer susceptibility has been widely studied, however, with divergent results.Totally, 9,910 patients 11,239 control subjects were enrolled. is associated an increased to (A-allele vs. V-allele: OR = 1.06, 95% CI 1.00 - 1.13, P 0.047; AA+AV VV: 1.09, 1.02 1.16, 0.008), especially for prostate (PCa). Serum SOD2 level of PCa VV+VA genotypes was lower than in those AA genotypes. expression downregulated both...
Abstract Cell elongation is a fundamental process for plant growth and development. Studies have shown lipid metabolism plays important role in cell elongation; however, the related functional mechanisms remain largely unknown. Here, we report that cotton (Gossypium hirsutum) LIPID TRANSFER PROTEIN4 (GhLTP4) promotes fiber via elevating ceramides (Cers) content activating auxin-responsive pathways. GhLTP4 was preferentially expressed elongating fibers. Over-expression down-regulation of led...
Long non-coding RNAs (lncRNAs) have been indicated as the candidate factors to predict cancer prognosis. However, it is still unknown whether lncRNA combinations may be utilized for predicting overall survival (OS) of prostate (PCa). The present work focused on selecting potent OS-related signature PCa and studying its molecular mechanism enhance prognosis prediction accuracy. Differentially expressed lncRNAs (DElncRNAs) or differentially genes (DEGs) were obtained based TCGA database by R...
Abstract For the multistage progression of prostate cancer (PCa) and resistance to immunotherapy, tumour‐associated macrophage is an essential contributor. Although immunotherapy important promising treatment modality for cancer, most patients with PCa are not responsive towards it. In addition exploring new therapeutic targets, it imperative identify highly immunotherapy‐sensitive individuals. This research aimed establish a signature risk model, which derived from macrophage, assess...
The correlation between rs1205, rs2808630 variants of C-reactive protein (CRP) gene and susceptibility cancer has been assessed previously, but with conflicting results. We adopted odds ratios (ORs) 95% confidence intervals (CIs), in silico tools enzyme-linked immunosorbent assay (ELISA) analysis to evaluate this association. Totally, 10,614 subjects 33,294 controls were involved the pooled analysis. When all studies pooled, no significant was indicated two risk. However, stratification by...
Kidney renal clear cell carcinoma (KIRC) is a subtype of that threatens human health. The mechanism by which the trophinin-associated protein (TROAP)-an important oncogenic factor-functions in KIRC has not been studied. This study investigated specific TROAP functions KIRC.
DNA repair genes (EG: xeroderma pigmentosum group D, XPD) may affect the capacity of encoded enzymes to effectively remove adducts or lesions, which result in enhanced cancer risk. The association between XPD gene polymorphisms and susceptibility prostate (PCa) was inconsistent previous studies.A meta-analysis based on 9 independent case-control studies involving 3165 PCa patients 3539 healthy controls for Gln751Lys SNP (single nucleotide polymorphism) 2555 cases 3182 Asn312Asp performed...
This study was aimed to analyze the potential role of Corin in procession diabetic ED and explore underlying mechanism. Diabetic rat model constructed characteristics control rats were recorded at 4, 8, 12, 16 weeks. qRT-PCR Western bloting used detected mRNA protein levels. Intracellular cGMP detection accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from corpus cavernosum spiral artery isolated transfected with si- analyzed Corin. Cell viability assessed...
To describe the clinical parameters of urinary stones and investigate preoperative predictors sepsis in patients following percutaneous nephrolithotomy (PCNL). Patients Methods. A retrospective study who underwent PCNL between August 2017 December 2019 was performed. The were divided into nonsepsis groups according to whether they had sepsis, their data compared for further analysis.Fifteen (6.1%) matching age, gender, body mass index (BMI), number access variables included group....
Cotton fiber is the most important natural textile material in world. Identification and functional characterization of genes regulating development are fundamental for improving quality yield. However, stable cotton transformation time-consuming, low efficiency, technically complex. Moreover, heterologous systems, such as Arabidopsis tobacco, did not always work to elucidate function specifically expressed or their promoters. For these reasons, constructing a rapid system using fibers...
In our previous studies, we found that the rs231775 polymorphism of cytotoxic T-lymphocyte antigen 4 (CTLA-4) is associated with risks different cancer types; however, association remains controversial and ambiguous, so conducted an in-depth meta-analysis to verify association. A complete search PubMed, Google Scholar, Embase, Chinese databases, Web Science was without regard language limitations, covering all publications since November 20, 2021. The criteria for susceptibility in CTLA-4...
A two-electron reductase known as NQO1 [NAD(P)H quinone oxidoreductase 1] is regarded an excellent anticancer target. Studies have found that rs1800566 polymorphism of linked to different cancers, but their associations remain controversial.In the present work, we selected do a comprehensive meta-analysis analyze correlation. We performed searches on PubMed, Embase, Google Scholar, Chinese database, and Web Science. The results obtained covered all publications before April 3, 2022.There...