A5049132806- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- Genomics and Phylogenetic Studies
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- MicroRNA in disease regulation
- Cardiovascular Effects of Exercise
- Crystallization and Solubility Studies
- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Molecular Biology Techniques and Applications
- Hepatitis B Virus Studies
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Angiogenesis and VEGF in Cancer
- Phytoplasmas and Hemiptera pathogens
- Liver Disease and Transplantation
- Bacteriophages and microbial interactions
- Biopolymer Synthesis and Applications
- Cancer Genomics and Diagnostics
- X-ray Diffraction in Crystallography
University of St. Gallen
2022-2024
State Key Laboratory of Digital Medical Engineering
2015-2023
Southeast University
2015-2023
Nanjing Medical University
2007-2008
Jiangsu Province Hospital
2007-2008
Aptamers are short single-stranded DNA or RNA oligonucleotides and can be selected from synthetic combinatorial libraries in vitro. They have a high binding affinity specificity for their targets. Agarose gels, nitrocellulose membranes, adsorptive microplates often used as carriers to immobilize targets the SELEX (systematic evolution of ligands by exponential enrichment) process, but subsequent separation step is tedious time-consuming. Therefore, we magnetic nanoparticles (MNPs) target,...
Hydrogel microspheres sensitive to temperature as new potential signal enhancers and magnetic fluorescent nanoparticles internal standards were used establish a CLIA method for the accurate diagnosis of cTnI in human body.
We present a low-cost microfluidic cartridge design scheme that combines gravity-driven passive pumping with extraction-free amplification to achieve “sample-in, answer-out” point-of-care nucleic acid detection within 30 minutes.
Abstract The human quest for beauty is manifested in numerous body decoration fashions such as makeups, tattoos, and stickers. ancient “kirigami” art offers a variety of choices sticker‐type beautification, whereby with simple cutting, complex networks potential use microfluidic channels stretchable materials can be fabricated. Inspired by the fish‐scale pattern kirigami art, fish‐like wearable biosensor designed This highly stretchable, well‐aerated, disposable, fish sticker enables sweat...
We report an enzyme-link immunosorbent assay (ELISA) based on patterned pseudopaper that is made of photonic nitrocellulose for highly sensitive fluorescence bioanalysis. The fabricated using self-assembled monodisperse SiO2 nanoparticles are a polypropylene substrate as template. have close-packed hexagonal (opal) structure, so the resulting has complementary (inverse opal) structure. Owing to slow-photon effect emission ELISA enhanced by up 57-fold without increasing time or complexity. As...
During seasonal influenza or emerging respiratory outbreaks, rapid home-based multiplex molecular point-of-care testing (POCT) for pathogens is crucial early diagnosis and intervention, particularly in vulnerable populations. However, existing...
Abstract Rapid early disease prevention or precise diagnosis is almost impossible in low‐resource settings. Natural ordered structures nature have great potential for the development of ultrasensitive biosensors. Here, motivated by unique and extraordinary functionalities nature, a biosensor based on butterfly wings presented. In this study, flexible Morpho menelaus ( M. ) wearable sensor integrated with microfluidic system electronic networks to facilitate neurodegenerative (ND). section,...
1. It has been well established that oestrogens can increase the number of endothelial progenitor cells (EPC) by anti-apoptotic effects. Resveratrol, a polyphenolic phytoalexin extracted from grapes and wine, reported to act as an oestrogen receptor agonist. We hypothesize putative phyto-oestrogen may promote EPC proliferation survival in vitro. 2. Endothelial were isolated human peripheral blood identified immunocytochemically. incubated with resveratrol (1, 10, 25 50 mmol/L) or control for...
In this work we report a method for the fabrication of opal capillary with multiple heterostructures aptamer-based assays. The is inspired by plant transpiration. During fabrication, monodisperse SiO2 nanoparticles (NPs) self-assemble in glass capillary, solvent gradually evaporating from top end capillary. By simple change colloid solution that wicks through can be easily prepared inside On surface NPs, polydopamine coated immobilization aminomethyl-modified aptamers. aptamers are used...
Patients with cancer are at high risk for severe coronavirus disease 2019 (COVID-19) infection. Knowledge regarding the efficacy of messenger RNA (mRNA) vaccines in actively treated patients is limited as they had been excluded from pivotal studies these vaccines. We evaluated humoral and cellular immune responses after double vaccination a booster dose identified disease- treatment-related factors associated reduced response. also documented number outcome breakthrough infections.Patients...
Abstract Background Hepatitis B virus (HBV) replication has been reported to be involved in many extrahepatic viral disorders; however, the mechanism by which HBV is trans-infected into tissues such as associated myocarditis remains largely unknown. Results In this study, we showed that human cord blood endothelial progenitor cells (EPCs), but not umbilical vein (HUVECs) could effectively infected uptake of vitro. Exposure EPCs with resulted DNA and particles were detected at day 3 after...
The accuracy and precision of analyte concentrations measured in whole blood by chemiluminescence immunoassay (CLIA) have been significantly affected erythrocytes, which leads to poor application CLIA clinical practice. In this work, a biosensing optical platform for hematocrit (HCT) analysis using MAGICL 6000 (Getein Biotechnology, Nanjing, China) was designed, implemented, fully characterized. developed method successfully applied determine various HCT levels human from 0% 65%, with...
Summary. We have previously showed that endothelial progenitor cells (EPCs) through uptake of hepatitis B virus (HBV) may play a critical role in mediating extrahepatic HBV diseases. However, it remains to be elucidated whether mesenchymal stem (MSCs) are capable trans‐infection into tissues. Methods and Results: In this study, we antigens, DNA the viral particles were detected MSCs after 3 days challenge. Neither covalently closed circular nor pregenomic RNA MSCs. Intravenously...