A5101731912- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Disaster Response and Management
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- IL-33, ST2, and ILC Pathways
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Cardiac Ischemia and Reperfusion
- Disaster Management and Resilience
- Magnetic and Electromagnetic Effects
- Advanced Glycation End Products research
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Music and Audio Processing
- Calcium signaling and nucleotide metabolism
- Ion Channels and Receptors
- Intensive Care Unit Cognitive Disorders
Nankai University
2014-2025
Shengli Oilfield Central Hospital
2024-2025
Shihezi University
2025
Jiangxi Academy of Sciences
2024
Chinese Academy of Sciences
2005-2024
University of Science and Technology of China
2024
First Affiliated Hospital of Shihezi University Medical College
2024
Xinjiang Production and Construction Corps
2022-2024
Tianjin People's Hospital
2024
Hainan Medical University
2021-2023
Myocardial injury as one of the severe complications leads to increasing morbidity and mortality in patients with sepsis. Recent studies reported that reactive oxygen species (ROS)-mediated ferroptosis plays a critical role development heart diseases. Therefore, we hypothesized anti-ferroptosis agent might be novel potential therapeutic strategy for sepsis-induced cardiac injury. Herein, demonstrated small biocompatible MRI-visible melanin nanoparticles (MMPP) improves myocardial function by...
T20 (generic name: Enfuvirtide, brand Fuzeon) is the only FDA-approved HIV fusion inhibitor that being used for treatment of HIV/AIDS patients who have failed to respond current antiretroviral drugs. However, it rapidly induces drug resistance in vitro and vivo. On basis structural functional information anti-HIV peptides from a previous study, we designed an named CP32M, 32-mer synthetic peptide highly effective inhibiting infection by wide range primary HIV-1 isolates multiple genotypes...
On the basis of structures small-molecule hits targeting HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole (2, NB-2), and N-(3-carboxy-4-chloro)phenylpyrrole (A1, NB-64), 42 N-carboxyphenylpyrrole derivatives in two categories (A B series) were designed synthesized. We found that 11 compounds exhibited promising anti-HIV-1 activity at micromolar level their antiviral was correlated with inhibitory on gp41 six-helix bundle formation, suggesting these block HIV fusion entry by...
The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether mechanism related AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test H2O2-treated rat cardiomyocytes (H9c2) were used in this study. Met treatment significantly improved left ventricular (LV) function, reduced infarct size CK-MB release comparison with IR group. Decreased TUNEL staining positive cells also observed IR+Met group ex vivo. markedly...
Numerous studies have found that chronic stress could promote tumor progression and this may be related to inhibtion of immune system. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population with immunosuppressive activity. MDSCs represent key link between progression. However, the role stress-induced in breast cancer is unclear. The present study showed pre-exposure lead elevation facilitated metastasis tumor-bearing mice. Adoptive transfer significantly increase lung...
Human immunodeficiency virus type 1 (HIV-1) entry into the host cell involves a cascade of events and currently represents one most attractive targets in search for new antiviral drugs. The fusion-active gp41 core structure is stable six-helix bundle (6-HB) folded by its trimeric N-terminal heptad repeat (NHR) C-terminal (CHR). Peptides derived from CHR region HIV-1 are potent fusion inhibitors that target NHR to block viral cellular membrane dominant negative fashion. However, all peptides...
Syringaresinol (SYR) is a phenolic compound, which could be found in various cereals and medicinal plants. It exerts both anti-inflammatory antioxidant pharmacological properties. However, little known about the effect of SYR on modulating diabetic cardiomyopathy. The present study aimed to investigate pharmacodynamic cardiomyopathy underlying molecular mechanism.In STZ-induced type 1 mice, orally administration with every other day for 8 weeks significantly improves cardiac dysfunction...
Background: Exercise training (ET) has a protective effect on the progression of heart failure, however, specific mechanism not been fully explored. Myeloid-derived suppressor cells (MDSCs) are group myeloid-derived immunosuppressive cells, which showed in failure. Thus, we hypothesized that ET failure may be related to infiltration MDSCs. Methods: C57BL/6 mice were made run treadmill 6× week for 4 weeks followed by isoproterenol injection from third week. Heart function was evaluated...
Early diabetic retinopathy (DR) is characterized by chronic inflammation, excessive oxidative stress, and retinal microvascular damage. Syringaresinol (SYR), as a natural polyphenolic compound, has been proved to inhibit many disease progression due its antiinflammatory antioxidant properties. The present study focuses on exploring the effect of SYR hyperglycemia-induced early DR well underlying mechanisms.
Abstract Disseminated intravascular coagulation (DIC) is considered to be the most common and lethal complication of sepsis. NLR-family pyrin domain-containing-3 (NLRP3) inflammasome plays an important role in host defense against microbial pathogens, its deregulation may cause cascade should strictly managed. Here, we identified deubiquitinase YOD1, which played a vital regulating NLRP3 inflammasome-dependent manner sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA). YOD1...
Objective: Caveolin-1 (Cav-1) plays a crucial role in maintaining the homeostasis of vascular endothelium. Endothelial dysfunction is involved many ischemic diseases. However, Cav-1 myocardial infarction (MI) has not been fully elucidated. Here, this study aims to delineate function MI injury and its impact on endothelial homeostasis. Methods: To elucidate vivo, we generated global knockout (Cav-1-KO) mice. And manipulated expression by siRNA vitro evaluate effects apoptosis, inflammatory...
The fusogenic human immunodeficiency virus type 1 (HIV-1) gp41 core structure is a stable six-helix bundle formed by its N- and C-terminal heptad repeat sequences. Notably, the negatively charged residue Asp(632) located at pocket-binding motif in interacts with positively Lys(574) pocket formation region of N-terminal to form salt bridge. We previously demonstrated that plays an essential role infectivity key determinant target for anti-HIV fusion inhibitors. In this study, functionality...
We previously identified a small-molecule anti-human immunodeficiency virus type 1 (anti-HIV-1) compound, ADS-J1, using computer-aided molecular docking technique for primary screening and sandwich enzyme-linked immunosorbent assay (ELISA) as secondary method. In the present study, we demonstrated that ADS-J1 is an HIV-1 entry inhibitor, determined by time-of-addition HIV-1-mediated cell fusion assay. Further mechanism studies confirmed does not block gp120-CD4 binding exhibits marginal...
This qualitative study was designed to assess health care volunteers' experiences and psychosocial impacts associated with deployment the West Africa Ebola epidemic.In 2015, using snowball sampling, 16 US volunteers who had recently returned from were recruited for this study. Semi-structured interviews conducted collect information each phase of (pre, peri, post).Participants reported that they motivated volunteer because a sense responsibility feelings empathy altruism. Immediately prior...
Pathways to biomedical careers are not being pursued with equal vigilance among all students. Emerging research shows that historically underrepresented (HU) students who maintain a strong science identity more likely persist. However, the influence of social support on persistence is less studied, especially as it relates doctoral To fill this gap, 1-year study assess similarities and differences 101 HU majority was conducted measure extent which 1) they report equivalent experiences...
Audio-visual speech recognition employing both acoustic and visual information is a novel extension of it significantly improves the accuracy in noisy environments. Although various audio-visual speech-recognition systems have been developed, rigorous detailed comparison potential geometric features from speakers' faces essential. Thus, this paper are compared analyzed rigorously for their importance recognition. Experimental results show that among analyzed, lip vertical aperture most...
ABSTRACT T20 (generic name, enfuvirtide; brand Fuzeon) is a first-generation human immunodeficiency virus (HIV) fusion inhibitor approved for salvage therapy of HIV-infected patients refractory to current antiretroviral drugs. However, its clinical use limited because rapid emergence T20-resistant viruses in T20-treated patients. Therefore, T1249 and T1144 are being developed as the second- third-generation HIV inhibitors, respectively, with improved efficacy drug resistance profiles. Here,...
Peptides derived from N-terminal heptad repeat (NHR) of the HIV-1 gp41 are generally poor inhibitors entry, because they tend to aggregate and do not form a trimeric coiled-coil. In this study, we have fused portions NHR, e.g. N36 or N28, T4 fibritin trimerization domain, Foldon (Fd), thus constructing novel NHR trimers, designated N36Fd N28Fd, which could be expressed in Escherichia coli cells. The purified N28Fd exhibited SDS-resistant coiled-coil conformation with improved alpha-helicity...
Staphylococcus aureus ( S. ) is a foodborne pathogen that causes severe diseases, such as endocarditis, sepsis, and bacteremia. As an important component of innate immune system, the NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays critical role in defense against infection. However, cellular mechanism NLRP3 activation during infection remains unknown. In present study, we found spleen tyrosine kinase (Syk) c-Jun N-terminal (JNK) were rapidly phosphorylated Moreover, Syk/JNK...