A5033036122- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammation biomarkers and pathways
- Cardiac Fibrosis and Remodeling
- Cancer Mechanisms and Therapy
- Intensive Care Unit Cognitive Disorders
- Protein Degradation and Inhibitors
- GDF15 and Related Biomarkers
- Signaling Pathways in Disease
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Paraoxonase enzyme and polymorphisms
- Biomarkers in Disease Mechanisms
- Phytochemicals and Antioxidant Activities
First Affiliated Hospital of Xi'an Jiaotong University
2024
Nankai University
2020-2023
Numerous studies have found that chronic stress could promote tumor progression and this may be related to inhibtion of immune system. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population with immunosuppressive activity. MDSCs represent key link between progression. However, the role stress-induced in breast cancer is unclear. The present study showed pre-exposure lead elevation facilitated metastasis tumor-bearing mice. Adoptive transfer significantly increase lung...
Finding the oncogene, which was able to inhibit tumor cells intrinsically and improve immune answers, will be future direction for renal cancer combined treatment. Following patient sample analysis signaling pathway examination, we propose p21-activated kinase 4 (PAK4) as a potential target drug kidney cancer. PAK4 exhibits high expression levels in samples plays regulatory role microenvironment.
Syringaresinol (SYR) is a phenolic compound, which could be found in various cereals and medicinal plants. It exerts both anti-inflammatory antioxidant pharmacological properties. However, little known about the effect of SYR on modulating diabetic cardiomyopathy. The present study aimed to investigate pharmacodynamic cardiomyopathy underlying molecular mechanism.In STZ-induced type 1 mice, orally administration with every other day for 8 weeks significantly improves cardiac dysfunction...
Background: Exercise training (ET) has a protective effect on the progression of heart failure, however, specific mechanism not been fully explored. Myeloid-derived suppressor cells (MDSCs) are group myeloid-derived immunosuppressive cells, which showed in failure. Thus, we hypothesized that ET failure may be related to infiltration MDSCs. Methods: C57BL/6 mice were made run treadmill 6× week for 4 weeks followed by isoproterenol injection from third week. Heart function was evaluated...
Background and Purpose: Diabetic nephropathy (DN) is one of the most serious microvascular complications diabetes that has limited treatment options. NLRP3-initiated pyroptosis tightly implicated in DN progression. Mitochondrial ROS (mtROS) are a critical trigger NLRP3 activation. Syringaresinol, natural plant-derived polyphenolic compound, possesses strong antioxidant properties. However, whether syringaresinol provides renoprotection remains unclear. Experimental Approach: The effects were...