A5029488879- Tea Polyphenols and Effects
- Food Quality and Safety Studies
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Phytochemicals and Antioxidant Activities
- Fermentation and Sensory Analysis
- Plant Molecular Biology Research
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Plant biochemistry and biosynthesis
- Viral Infections and Immunology Research
- Microbial Metabolism and Applications
- Plant-Microbe Interactions and Immunity
- Antimicrobial Resistance in Staphylococcus
- Phytoestrogen effects and research
- Spine and Intervertebral Disc Pathology
- Bacterial biofilms and quorum sensing
- Insect and Pesticide Research
- Viral Infectious Diseases and Gene Expression in Insects
- Polyamine Metabolism and Applications
- Viral gastroenteritis research and epidemiology
- Plant tissue culture and regeneration
- Polysaccharides and Plant Cell Walls
- Postharvest Quality and Shelf Life Management
- Fungal Biology and Applications
Anhui Agricultural University
2015-2025
First Affiliated Hospital of Nanchang University
2021-2025
Nanchang University
2021-2025
Hangzhou Center for Disease Control and Prevention
2019-2024
Ministry of Agriculture and Rural Affairs
2023-2024
XinHua Hospital
2024
Inner Mongolia Agricultural University
2024
Nantong University
2021-2023
Zhejiang Chinese Medical University
2023
Shandong Agricultural University
2018-2023
Significance A high-quality genome assembly of Camellia sinensis var. facilitates genomic, transcriptomic, and metabolomic analyses the quality traits that make tea one world’s most-consumed beverages. The specific gene family members critical for biosynthesis key metabolites, monomeric galloylated catechins theanine, are indicated found to have evolved specifically these functions in plant lineage. Two whole-genome duplications, evolution two identified dated, but shown account less...
Abstract Background Tea is one of the most popular non-alcoholic beverages worldwide. However, tea plant, Camellia sinensis , difficult to culture in vitro transform, and has a large genome, rendering little genomic information available. Recent advances large-scale RNA sequencing (RNA-seq) provide fast, cost-effective, reliable approach generate expression datasets for functional analysis, which especially suitable non-model species with un-sequenced genomes. Results Using high-throughput...
Interview with Dr. Roy Perlis on esketamine as an option for treatment-resistant depression. (08:16)Download The FDA has approved esketamine, the first antidepressant in a new class, agency weighed drug's rapid onset of effect against its abuse potential, which led to Risk Evaluation and Mitigation Strategy.
Photodynamic therapy (PDT) is a clinical cancer treatment modality based on the induction of therapeutic reactive oxygen species (ROS), which can trigger immunogenic cell death (ICD). With aim simultaneously improving both PDT-mediated intracellular ROS production and ICD levels, we designed serum albumin (SA)-coated boehmite ("B"; aluminum hydroxide oxide) organic-inorganic scaffold that could be loaded with chlorin e6 (Ce6), photosensitizer, honey bee venom melittin (MLT) peptide, denoted...
ABSTRACT Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage trivalent oral vaccine (tOPV) been low. Phylogenetic analysis of P1/capsid region sequences isolates from each the 403 cases reported 2005 to 2011 resolved into 23 independent (VDPV2) emergences, at least 7 which established lineage groups. Virus one emergence (lineage group 2005-8; 361 isolates) was estimated...
Tea plants (Camellia sinensis) are used to produce one of the most important beverages worldwide. The nutritional value and healthful properties tea closely related large amounts three major characteristic constituents including polyphenols (mainly catechins), theanine caffeine. Although oil oleifera) belongs genus Camellia, this plant lacks these constituents. Comparative analysis via RNA-Seq would help uncover genetic components underlying biosynthesis metabolites in tea. We found that...
Tea is the most popular nonalcoholic beverage worldwide for its pleasant characteristics and healthful properties. Catechins, theanine caffeine are major natural products in tea buds leaves that determine qualities such as infusion colors, tastes fragrances, well their health benefits. Shading a traditional effective practice to modify product accumulation enhance quality plantation. However, mechanism underlying shading effects not fully understood. This study aims explore regulation of...
As a popular traditional fermented beverage, kombucha has been extensively studied for its health benefits. However, the science behind anti-inflammatory effect of not well studied, and there is an urgent need to uncover secrets properties kombucha. Here, we investigate kombucha's protective effects against lipopolysaccharide (LPS)-induced sepsis on intestinal microecology in mice. The contents reducing sugars, polyphenols, catechins, organic acids group were identified using various...
Theanine is an important secondary metabolite endowing tea with umami taste and health effects. It essential to explore the metabolic pathway regulatory mechanism of theanine improve quality. Here, we demonstrated that expression patterns CsGGT2 (γ-glutamyl-transpeptidase), participated in synthesis vitro our previous research, are significantly different aboveground underground tissues plants regulated by light. Light up-regulated CsHY5, directly binding promoter acting as activator CsGGT2,...
Abstract Theanine metabolism is a necessary biological process during the planting and production of tea that determines quality. There currently little knowledge about transcriptional regulation theanine in plants. In this study, we demonstrated γ-glutamyl-transpeptidase CsGGT4, as homologous protein hydrolase CsGGT2, exhibited higher synthesis catalytic efficiency. Homology modeling molecular docking showed differential structures between CsGGT2 CsGGT4 implied their different functions...
Three genes, mcbABC, that drive the biosynthesis of marinacarbolines, have been elucidated through genome mining, gene inactivation, heterologous expression, feeding, and site-directed mutagenesis experiments. McbB is highlighted as a novel enzyme for β-carboline core construction, which involves Pictet–Spengler cyclization process requiring E97 biochemical activity. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer...
Fermented tea (FT) using a single Eurotium cristatum strain can produce pleasant fungal-flowery aroma, which is similar to the composite aroma characteristic of minty, flowery, and woody aromas, but its molecular basis not yet clear. In this study, solvent-assisted flavor evaporation gas chromatography-mass spectrometry/olfactometry were applied isolate identify volatiles from FT by E. cristatum. The application an extract dilution analysis screened out 43 aroma-active compounds....
Loose-leaf dark tea fermented by Eurotium cristatum has increasingly gained favor in the market due to its unique fungal aroma and soft mouthfeel. In this study, dynamic changes metabolite profile taste characteristics of loose-leaf were investigated. Ninety-two critical metabolites identified during fermentation ultraperformance liquid chromatography coupled with Q-Exactive Orbitrap tandem mass spectrometry (UPLC-Q-Exactive Orbitrap/MS). Among these metabolites, catechin derivatives...