A5063826264- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Retinal Development and Disorders
- Tryptophan and brain disorders
- Neurobiology and Insect Physiology Research
- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Memory and Neural Mechanisms
- Advanced biosensing and bioanalysis techniques
- Anesthesia and Sedative Agents
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Intensive Care Unit Cognitive Disorders
- Neuroendocrine regulation and behavior
- Anesthesia and Neurotoxicity Research
- Olfactory and Sensory Function Studies
California University of Pennsylvania
2024
University of Pennsylvania
2014-2024
New York University
2012-2020
University of Pennsylvania Health System
2020
Pennsylvania State University
2011
How sleep helps learning and memory remains unknown. We report in mouse motor cortex that after promotes the formation of postsynaptic dendritic spines on a subset branches individual layer V pyramidal neurons. New are formed different sets response to tasks protected from being eliminated when multiple learned. Neurons activated during task reactivated subsequent non-rapid eye movement sleep, disrupting this neuronal reactivation prevents branch-specific spine formation. These findings...
Abstract Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on bacterial periplasmic binding protein. iAChSnFR shows large fluorescence changes, rapid rise decay kinetics, insensitivity to most cholinergic drugs. revealed transients in variety of slice vivo preparations mouse, fish, fly worm. will be useful study acetylcholine all animals.
Experimental models of peripheral nerve injury have been developed to study mechanisms neuropathic pain in living animals. The spared (SNI) model rodents is a partial denervation model, which the common peroneal and tibial nerves are injured, producing consistent reproducible tactile hypersensitivity skin territory spared, intact sural nerve. SNI-operated mice require less force applied affected limb elicit withdrawal behavior as compared sham mice. This effect observed early 2 days after...
Administration of an AMPAkine prevents long-term deficits induced by repeated neonatal anesthesia.
Abstract Nitrous oxide (N 2 O) induces rapid and durable antidepressant effects in patients suffering from treatment-resistant depression 1,2 . The cellular circuit mechanisms mediating this process are not known. Here we find that a single dose of inhaled N O specific activation layer V (L5) pyramidal neurons the prefrontal cortex rodents exposed to chronic stress conditions. O-induced L5 rescues stress-associated hypoactivity state, persists following exposure, is necessary for its action....
Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on bacterial periplasmic binding protein. iAChSnFR shows large fluorescence changes, rapid rise decay kinetics, insensitivity to most cholinergic drugs. revealed transients in variety of slice vivo preparations mouse, fish, fly worm. will be useful study acetylcholine all organisms.
Psychedelic-induced experiences are thought to play an important role in the therapeutic actions of rapid-acting antidepressants. General anesthesia is one scenario which patients can be rendered unconscious and masked psychedelic treatment, providing a simple yet effective method examine drug-induced changes brain devoid experiences.
Nitrous oxide (N