A5008781913- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Advanced Fluorescence Microscopy Techniques
- Vestibular and auditory disorders
- Visual perception and processing mechanisms
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Research and Treatments
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Angiogenesis and VEGF in Cancer
- Olfactory and Sensory Function Studies
- Physiological and biochemical adaptations
- Renin-Angiotensin System Studies
- Radiopharmaceutical Chemistry and Applications
Champalimaud Foundation
2013-2024
University of Zurich
2008-2011
Goethe University Frankfurt
2004
University of Freiburg
2004
University Medical Center Freiburg
2003
Vision of high temporal resolution depends on careful regulation photoresponse kinetics, beginning with the lifetime activated photopigment. The activity rhodopsin is quenched by high-affinity binding arrestin to photoexcited phosphorylated photopigment, which effectively terminates visual transduction cascade. This mechanism well established for rod photoreceptors, yet its role cone vision still controversial. In this study we therefore analyzed function in cone-dominated larval zebrafish....
Until recently, it was generally accepted that the vascularization of solid tumors occurred exclusively through sprouting and co‐option from preexisting blood vessels. Growing evidence now suggests bone marrow‐derived endothelial progenitor cells (EP) circulate in may play an important role formation new vessels certain tumors. Whether progenitors participate brain has not yet been evaluated. In this study, we examined contribution EP to tumor angiogenesis a murine glioma model. Donor marrow...
Cardiac arrhythmias are among the most challenging human disorders to diagnose and treat due their complex underlying pathophysiology.Suitable experimental animal models needed study mechanisms causative for cardiac arrhythmogenesis.To enable in vivo analysis of cellular electrophysiology with a high spatial temporal resolution, we generated carefully validated two zebrafish models, one expressing an optogenetic voltage indicator (chimeric VSFP-butterfly CY) other genetically encoded calcium...
Sensory systems must reduce the transmission of redundant information to function efficiently. One strategy is continuously adjust sensitivity neurons suppress responses common features input while enhancing new ones. Here we image excitatory synaptic inputs and outputs retinal ganglion cells understand how such dynamic predictive coding implemented in analysis spatial patterns. Synapses bipolar become tuned orientation through presynaptic inhibition, generating lateral antagonism domain....
The olivo-cerebellar system plays an important role in vertebrate sensorimotor control. Here we investigate sensory representations the IO of larval zebrafish and their spatial organization. Using single-cell labeling genetically identified neurons find that they can be divided into at least two distinct groups based on location, dendritic morphology, axonal projection patterns. In same targeted population, recorded calcium activity response to a set visual stimuli using two-photon imaging....
Abstract The olivo-cerebellar system plays an important role in vertebrate sensorimotor control. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning cerebellum. Here we investigate sensory representations IO larval zebrafish and their spatial organization. Using single-cell labeling genetically identified neurons find that they can be divided into at least two distinct groups based on...
Summary Sensory systems must reduce the transmission of redundant information to function efficiently. One strategy is continuously adjust sensitivity neurons suppress responses common features input while enhancing new ones. Here we image both excitatory synaptic inputs and outputs retinal ganglion cells understand how such dynamic predictive coding implemented in analysis spatial patterns. Synapses bipolar become tuned orientation through presynaptic inhibition generating lateral...
From lamprey to monkeys, the organization of descending control locomotion is conserved across vertebrates. Reticulospinal neurons (RSNs) form a bottleneck for commands, receiving innervation from diencephalic and mesencephalic locomotor centres providing drive spinal motor circuits. Given their optical accessibility in early development, larval zebrafish offer unique opportunity study reticulospinal circuitry. In fish, RSNs are small, highly stereotyped, uniquely identifiable group large...