A5048221702- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Sexual function and dysfunction studies
- Testicular diseases and treatments
- Medicinal Plants and Bioactive Compounds
- Invertebrate Immune Response Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Chemotherapy-induced organ toxicity mitigation
- Occupational Health and Safety Research
- Sperm and Testicular Function
- Medicinal Plants and Neuroprotection
- Plant tissue culture and regeneration
- Hormonal and reproductive studies
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Natural product bioactivities and synthesis
- Plant Molecular Biology Research
- Human-Automation Interaction and Safety
Changchun University of Chinese Medicine
2019-2024
Accumulation of amyloid-β (Aβ), which results in the formation senile plaques that cause oxidative damage and neuronal cell death, has been accepted as major pathological mechanism Alzheimer's disease (AD). Hence, inhibition Aβ-induced apoptosis represents effective strategies combating AD. Ginsenoside Re (Re) pharmacological effects against neurotoxicity. However, its molecular remains elusive. The present study evaluated effect cytotoxicity SH-SY5Y cells, investigated underlying mechanism....
Ginsenoside Rh2 (G‑Rh2) is a monomeric compound that extracted from ginseng and possesses anti‑cancer activities both in vitro vivo. Previously, we reported G‑Rh2 induces apoptosis HeLa cervical cancer cells the process was related to reactive oxygen species (ROS) accumulation mitochondrial dysfunction. However, upstream mechanisms of G‑Rh2, along with its cellular targets, remain be elucidated. In present study, Cell Counting Kit‑8 assay, flow cytometry Hoechst staining revealed...
Ginsenosides, active substances in Panax ginseng C. A. Meyer (ginseng), extend lifespan multiple species, ameliorate age-associated damage, and limit functional decline tissues. However, their components molecular mechanisms are largely unknown. Here, ginsenoside Rg1 (Rg1) promoted longevity Saccharomyces cerevisiae. Treatment with decreased aging-mediated surface wrinkling, enhanced stress resistance, reactive oxygen species' production apoptosis, improved antioxidant enzyme activity, the...
Leydig cell injury has been described as a primary driver of testicular dysfunction and is affected by oxidative stress. Dioscorea polystachya (Chinese yam) used to improve in clinical pharmacological research via its antioxidative activity, but the mechanisms underlying beneficial effect Chinese yam on suppression damage remain unclear. In this study, we obtained protein (DP1) explored effectiveness possible mechanism improving vivo vitro. We established model rats using hydrocortisone...
Pueraria Lobata Radix (P. Radix) is an edible traditional Chinese medicine that contains various active compounds. Proteins from P. have become the subject of increased interest in recent years. In evaluating whitening effect on skin, present study found water‑soluble total protein extract (PLP) had strongest inhibitory tyrosinase activity. study, anti‑melanogenic PLP and B16 melanoma cells were investigated. significantly reduced activity melanin content cells. Mechanistically, inhibited...