A5100433596- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Chemical synthesis and alkaloids
- Aortic Disease and Treatment Approaches
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Immune Response and Inflammation
- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Computational Drug Discovery Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Eicosanoids and Hypertension Pharmacology
- Venous Thromboembolism Diagnosis and Management
Sichuan University
2025
West China Hospital of Sichuan University
2025
Hangzhou First People's Hospital
2024
Westlake University
2024
Nankai University
2024
Chinese PLA General Hospital
2024
Harbin Medical University
2024
State Key Laboratory of Kidney Diseases
2024
Zunyi Medical University
2016-2022
General Hospital of Central Theater Command
2021
Ischemic post‑conditioning (IPO) and diazoxide (DPO) has been proven to reduce myocardial ischemia reperfusion injury (MIRI); however, the mechanisms of IPO/DPO are still not clear. The present study aimed investigate whether mitochondrial ATP‑sensitive potassium channels (mitoKATP) activated by IPO/DPO, which may further activate hypoxia inducible factor 1/hypoxic response element (HIF‑1/HRE) pathway mitigate MIRI. Using a Langendorff perfusion device, healthy male (250‑300 g) Sprague...
Abstract Objectives Recent evidence indicates that suppressing inflammation by specific drug target and treatment measures contributes to attenuate ischaemic injury the related heart diseases. This study aimed investigate potential effect of baicalin on myocardial through inhibition inactivating aryl hydrocarbon receptor (AhR). Methods The mouse model with was prepared left anterior descending coronary artery-amputation then treated using baicalin. After observing expression AhR...
Endovascular thrombectomy has been confirmed to be an effective therapy for acute ischemic stroke (AIS). However, how functional brain networks reorganize after restoration of blood supply in AIS patients, and whether the degree reperfusion associates with network changes remains unclear.
Among its many biological roles, fibroblast growth factor-2 (FGF2) acutely protects the heart from dysfunction associated with ischemia/reperfusion (I/R) injury. Our laboratory has demonstrated that this is due to activity of low molecular weight (LMW) isoform FGF2 and FGF2-mediated cardioprotection relies on protein kinase C (PKC); however, which PKC isoforms are responsible for LMW cardioprotection, their downstream targets, remain be elucidated. To identify pathway(s) contributes...
Oxidative damage is a pathological factor that causes cardiovascular in the clinic and increasingly serious. This study focused on effect of fasudil H2O2-induced oxidative cardiomyocytes.H9C2 cardiomyocytes were cultured vitro divided into three groups: control group (Con group), H2O2 treatment (H2O2 cotreatment (H2O2+fasudil group). The content levels LDH MDA supernatant detected, morphology H9C2 was observed by light microscopy. 8-OHdG staining fluorescence inversion microscope. Cell...
Abstract Aim Patients with chronic kidney disease (CKD) are more susceptible to endothelial dysfunction and cardiovascular (CV). Remote ischemic preconditioning (rIPC) has been proven efficient in improving function lowering the risk of CV. However, safety effect rIPC on patients CKD have not effectively assessed. Methods 45 (average estimated glomerular filtration rate: 48.4 mL/min/1.73 m 2 ) were randomly allocated either 7‐day daily upper‐arm (4 × 5 min 200 mmHg, interspaced by 5‐min...
Abstract Objective: To explore the relationship between succinate dehydrogenase and mitoK ATP C in mechanism of ischemic postconditioning (IPO) attenuating myocardial ischemia-reperfusion injury (MIRI) under CPB adult rats. Methods: 160 male SD rats, SPF grade, weighing 300-350g. Established rat IPO models. Randomly divided into 8 groups with 20 animals each group: normal group (Nor), SDH competitive inhibitor Dimethyl malonate (dm) control (dm+ Nor), (I// R), dm+ I/R), ischemia (IPO), IPO),...
Abstract Background Myocardium ischemia/reperfusion (I/R) injury can be fatal in cardiac operations. Pinacidil postconditioning (PPO) could effectively alleviate I/R injury. however, the mechanisms are still not clear. Hypoxia-inducible factor-1 (HIF-1) acted as a mediator of ischemic and protected heart against detrimental acute This study aims at observing effects PPO on injury, exploring function HIF-1/hypoxia response element (HRE) pathway PPO’s myocardial protective effects. Methods...