A5026326409- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Folate and B Vitamins Research
- Protease and Inhibitor Mechanisms
- Cardiac pacing and defibrillation studies
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cancer Treatment and Pharmacology
- GDF15 and Related Biomarkers
- Pregnancy and preeclampsia studies
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Ferroptosis and cancer prognosis
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Ischemia and Reperfusion
- Esophageal and GI Pathology
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
Ningbo Medical Center Lihuili Hospital
2025
Ningbo University
2025
China Southern Power Grid (China)
2025
Zhejiang University
2012-2024
Shaoxing University
2006-2024
Shaoxing People's Hospital
2013-2023
Zhejiang Hospital
2023
Wenzhou Medical University
2015-2022
Zhejiang Chinese Medical University
2020
Johns Hopkins Medicine
2019
Abstract Arrhythmia constitutes a problem with the rate or rhythm of heartbeat, and an early diagnosis is essential for timely inception successful treatment. We have jointly optimized entire multi-stage arrhythmia classification scheme based on 12-lead surface ECGs that attains accuracy performance level professional cardiologists. The new approach comprised three-step noise reduction stage, novel feature extraction method optimal model finely tuned hyperparameters. carried out exhaustive...
Dietary polyphenols help to prevent cardiovascular diseases, and interactions between gut microbiota are known exist. In this study, we speculated that microbiota-mediated metabolite regulation might contribute the anticardiotoxic effects of yellow wine polyphenolic compound (YWPC) in doxorubicin (DOX)-treated rats.
This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing community composition structure of intestinal microbiota, 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor its therapeutic efficacy.
ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using...
Doxorubicin (DOX) is well-known for its potent antitumor activity but limited by multiple and serious adverse effects. A major effect acute cardiotoxicity; yet, mechanism has not been elucidated. Fucoidan a multifunctional nontoxic polysaccharide that widely studied because of favorable biological activities safety. Hence, we proposed fucoidan may play protective role in DOX-induced cardiotoxicity without causing additional side Sprague-Dawley rats were injected intraperitoneally with single...
Diabetic heart damage can lead to cardiomyocyte death, which endangers human health. Baicalin (BAI) is a bioactive compound that plays an important role in cardiovascular diseases. Sentrin/SUMO-specific protease 1 (
This study demonstrated for the first time protective effect of emodin against DIC and verified by FMT that its cardioprotective was achieved remodeling gut microbiota composition, resulting in attenuation ferroptosis. Furthermore, we these effects were mediated redox-related gene Nrf2.
Cardiac fibrosis is a major pathological manifestation of diabetic cardiomyopathy (DCM), which leads to cardiac remodeling, dilated and congestive heart failure. Human fibroblasts (HCF) constitute the predominant cell type in matrix metalloproteinases (MMPs) tissue inhibitors (TIMPs) are also involved fibrosis. However, it unclear whether high glucose levels affect expression MMPs TIMPs HCF. Sodium‑glucose cotransporter (SGLT) have been developed as therapeutic agents anti‑DCM effect SGLT...
BACKGROUND:Developing a simple and efficient method of obtaining primary cultured VSMCs is necessary for basic cardiovascular research. MATERIAL AND METHODS:The procedure our new mainly includes 6 steps: isolation the aortic artery, removal fat tissue around separation media, cutting media into small blocks, transferring blocks to cell culture plates, incubation until cells reach confluence. The were identified as by morphology immunofluorescence. Then, obtained this explants method,...
Aims: The relationship between the gut microbiota and cardiovascular system has been increasingly clarified. Fecal transplantation (FMT), used to improve microbiota, applied clinically for disease treatment great potential in combating doxorubicin (DOX)-induced cardiotoxicity. However, application of FMT field its molecular mechanisms are poorly understood.
Background: Cardiac fibroblast (CF) activation is a hallmark feature of cardiac fibrosis in diabetic cardiomyopathy (DCM). Inhibition the sodium-dependent glucose transporter 1 (SGLT1) attenuates cardiomyocyte apoptosis and delays development DCM. However, role SGLT1 CF remains unclear. Methods: A rat model DCM was established treated with si‐SGLT1 to examine fibrosis. In addition, vitro experiments were conducted verify regulatory proliferation collagen secretion high-glucose– (HG–) CFs....
Diabetic heart failure (DHF) or cardiomyopathy is a common complication of diabetes; however, the underlying mechanism not clear. In present study, authors searched for differentially expressed genes associated with DHF and molecular types immune cells based on bioinformatics. The RNA expression dataset was obtained from NCBI Gene Expression Omnibus (GEO) database. After preprocessing data, (DEGs) between group non-diabetic (NHF) were screened intersected immune-related (IRGs) in ImmPort...
Dietary polyphenols, polypeptides, and oligosaccharides modulate inflammation immunity by altering the composition of gut microbiota. The polyphenols polypeptides in Chinese rice wine have protective effects against cardiovascular disease. In this study, we hypothesized that can ameliorate diabetic cardiomyopathy (DCM) microbiota metabolites.Mice with DCM high glucose cells were treated (RWPH), (RWPE), oligosaccharides. Cardiac function was evaluated echocardiography detection myocardial...
Background Hyperhomocysteinemia is an independent risk factor of coronary artery disease, but some studies have shown that patients with hyperhomocysteinemia are not prone to atherosclerosis. The aim this study was test whether homocysteine increases the production matrix metalloproteinase-2 (MMP-2) and if extracellular additional magnesium folic acid alters MMP-2 secretion. Methods Results Gelatin zymography western blotting were used investigate effects different levels (0-5,000 μmol/L) on...
Abstract Introduction A left common pulmonary vein (LCPV) is a anatomical variant in atrial fibrillation (AF) patients. Whether an LCPV influences outcomes of repeated radiofrequency catheter ablation (RFCA) for AF has not been elucidated. Methods From prospectively collected database, we enrolled 154 patients who received RFCA recurrent after the initial (56 ± 9 years, 72% paroxysmal AF, 32 with LCPV, and 122 typical left‐sided veins [PVs]). Median postprocedural follow‐up was 26 months....