A5103007305- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Neurological Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- MicroRNA in disease regulation
- Urban Transport and Accessibility
- Traditional Chinese Medicine Analysis
- Urban Design and Spatial Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Viral Infections and Immunology Research
- Ginseng Biological Effects and Applications
- Heart Rate Variability and Autonomic Control
- Neuropeptides and Animal Physiology
- Renal and related cancers
- Cholesterol and Lipid Metabolism
- Extracellular vesicles in disease
- Biomarkers in Disease Mechanisms
- Pain Mechanisms and Treatments
- Reproductive Biology and Fertility
Ministry of Agriculture, Livestock, and Food Supply
2024
Northwest A&F University
2024
China Pharmaceutical University
2015-2024
China University of Geosciences (Beijing)
2024
China Medical University
2021-2022
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood-brain barrier (BBB) dysfunction after stroke remains unclear. This study aimed investigate the effects of ruscogenin BBB and underlying mechanisms in middle artery occlusion/reperfusion (MCAO/R)-injured mice oxygen-glucose deprivation/reoxygenation (OGD/R)-injured mouse brain microvascular endothelial cells...
Previously, we found that diabetes-related liver dysfunction is due to activation of the 5-HT2A receptor (5-HT2AR) and increased synthesis degradation 5-HT. Here, investigated role 5-HT in development atherosclerosis.The study was conducted using high-fat diet-fed male ApoE-/- mice, THP-1 cell-derived macrophages, HUVECs. Protein expression biochemical indexes were determined by Western blotting quantitative analysis kit, respectively. The following staining methods used: oil red O (showing...
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause cell apoptosis or death in the central nervous system (CNS) diseases, such neurodegenerative and psychiatric diseases.The application neuroprotectants rescuing from damage can be potential treatment for these CNS diseases.Ginsenoside Rg1 (Rg1), one major active components ginseng, reported possessing notable neuroprotective activities.However, there is rare report about its effect on...
Abstract GRS is a drug combination of three active components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula ShengMai preparations, widely used traditional Chinese medicine for treatment cardiovascular diseases in clinic. The present study explores cardioprotective effects on myocardial ischemia/reperfusion (MI/R) injury compared with preparations investigates underlying mechanisms. significantly attenuated MI/R exhibited similar efficacy as...
The study of the land use optimization urban agglomerations is great significance to rational utilization resources and sustainable development agglomerations. Previous studies have simply regarded agglomeration as a whole area or each city an isolated individual, without considering regional coordinated in objectives. This proposed first attempt couple Zipf's law multiobjective model agglomeration. was applied quantify it one objectives optimization. genetic algorithm adopted establish...
Abstract Accumulating evidence indicates that paternally derived microRNAs play a crucial role in the development of early embryos and are regarded as key factor successful somatic cell cloned embryos. In our previous study, bta-miR-301a was found to be highly expressed bovine sperm delivered into oocytes during fertilization. this bioinformatics, dual luciferase reporter assays, rescue experiments, gain- loss-of-function experiments indicated ACVR1 is target gene By microinjecting mimic...
Background: Dopamine receptors have been reported to be involved in pain, while the exact effects and mechanism bone cancer pain not fully explored.Methods: Bone model was created by implanting walker 256 mammary gland carcinoma into right tibia cavity.Primary cultured spinal neurons were used for vitro evaluation.FLIPR, western-blot, immunofluorescence, Co-IP detect cell signaling pathway.Results: Our results indicated that dopamine D1 receptor (D1DR) D2 (D2DR) could form heteromers TCI...
Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined alcoholic cardiomyopathy (ACM). Alcohol-mediated injury has previously been studied through metabolomics, and it proved to be involved in the Kyoto Encyclopedia of Genes Genomes (KEGG) pathway concerning unsaturated fatty acids biosynthesis oxidative phosphorylation, which tentatively explored mechanism ACM induced by chronic drinking. To further study...
Exosomal microRNAs (miRNAs) are miRNAs that mediated by exosomes to achieve cell-to-cell communication, and they widespread in organisms. In recent years, the key role of multiple biological functions exosomal occurrence development cardiovascular diseases has been confirmed a large number studies, which become hot spot clinical basic research. Sudden cardiac death caused disease is one important contents forensic medical identification. This article introduces research progress prediction,...