A5043400812- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Medicinal Plants and Neuroprotection
- Angiogenesis and VEGF in Cancer
- 14-3-3 protein interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Cystic Fibrosis Research Advances
- Celiac Disease Research and Management
- Genomics, phytochemicals, and oxidative stress
- Biomarkers in Disease Mechanisms
- Neonatal Respiratory Health Research
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Phytochemical Studies and Bioactivities
- Protein Kinase Regulation and GTPase Signaling
First Affiliated Hospital of Nanchang University
2016-2025
Nanchang University
2015-2024
Anhui Normal University
2023
Jiangxi University of Traditional Chinese Medicine
2021-2022
Yuhuangding Hospital
2021-2022
Qingdao University
2021
China Pharmaceutical University
2013-2017
Aston University
2014
Background and Purpose Non‐muscular myosin heavy chain IIA (NMMHC IIA) plays a key role in tissue factor expression venous thrombosis. Natural products might inhibit thrombosis through effects on NMMHC IIA. Here, we have shown that natural saponin, D39, from Liriope muscari exerted anti‐thrombotic activity vivo , by targeting Experimental Approach Expression of endothelial cells were analysed vitro Western blot simplified chromogenic assays. Interactions between D39 assessed serial affinity...
Myocardial ischemic/reperfusion injury results from severe impairment of coronary blood supply and leads to irreversible cell death, with limited therapeutic possibilities. Asiatic acid is a pentacyclic triterpenoid derived the tropical medicinal plant Centella asiatica serves variety bioactivities. In this study, we determined effect asiatic on myocardial ischemia/reperfusion investigated underlying mechanisms, using an in vitro rat H9c2 cardiomyocytes model oxygen-glucose...
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause cell apoptosis or death in the central nervous system (CNS) diseases, such neurodegenerative and psychiatric diseases.The application neuroprotectants rescuing from damage can be potential treatment for these CNS diseases.Ginsenoside Rg1 (Rg1), one major active components ginseng, reported possessing notable neuroprotective activities.However, there is rare report about its effect on...
Asiatic acid promotes Sirt1 expression and inhibits NF-κB-induced microglia activation.
Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor stroke-related deaths worldwide. Current treatments are limited, new, more effective prevention treatment strategies that target multiple cell components urgently needed. Leucine-rich alpha-2 glycoprotein 1 (Lrg1) appears be associated with the progression of cerebral injury, but exact mechanism it unknown.Wild-type (WT) Lrg1 knockout (Lrg1-/-) mice were used investigate role after injury....
Abstract Aim Myocardial injury is a significant cause of death. This study investigated the role and underlying mechanism interferon‐regulatory factor‐1 (IRF1) in bevacizumab (BVZ)‐induced cardiomyocyte injury. Methods results HL‐1 cells C57BL/6 mice receiving BVZ treatment were used to establish vitro vivo models myocardial The relationship between VEGFA 14‐3‐3γ was verified through co‐immunoprecipitation Glutathione S Transferase (GST) pull‐down assay. Cell viability apoptosis analysed by...
Asiatic acid is a reported glycogen phosphorylase inhibitor derived from the tropical medicinal plant Centella asiatica and exhibits myocardial protection both in vivo vitro. The purpose of this study was to evaluate effects asiatic on ischemia/reperfusion (MI/R) injury investigate underlying mechanisms associated with modulation glycometabolism cardiomyocyte.The rats were subjected MI/R or without pretreatment. cardiac function indexes, size infarction, plasma lactate dehydrogenase (LDH)...
Abstract Objectives This study was designed to investigate the effects and mechanism of Tanshinone IIA (TIIA) on endotoxic shock-induced lung injury in a mouse model. Methods Mice were administered intraperitoneally with TIIA (10 mg/kg) 0.5 h before lipopolysaccharide (LPS) challenge then received additional injections every 24 during 3-day experimental period. The physiological indexes, survival rate parameters for examined. protein levels Sirt1, acetylation activation NF-κB p65 determined....
Colon cancer is the third most common worldwide, and lymphatic metastasis one of principal factors affecting patient prognosis. Recent studies have revealed that long non-coding RNAs (lncRNAs) serve as important regulators in pathogenesis colon cancer, therefore survival rates. In present study, cancer-associated lncRNAs were screened based on their influence survival. A number survival-associated (and potential mechanisms action) identified, with strongest candidate being MIR210HG. Gene...
BACKGROUND:Protein kinase R (PKR) is implicated in the inflammatory response to bacterial infection while role of PKR sepsis-induced acute kidney injury (AKI) largely unknown. This study aimed investigate effects specific inhibitor C16 (C13H8N4OS) on lipopolysaccharide (LPS)-induced AKI, and its mechanisms action. MATERIAL AND METHODS:C57BL/6J mice were injected intraperitoneally with or vehicle 1 h before LPS challenge then 0.9% saline. After challenge, histopathological damage, renal...
Background: Post-stroke depression (PSD) is a major complication in stroke survivors, especially elderly survivors. But there are still no objective methods to diagnose Thus, this study was conducted identify potential biomarkers for diagnosing PSD subjects. Methods: Elderly (60 years or older) survivors with were assigned into the group, and without healthy controls (HCs) non-depressed group. Urinary metabolite signatures obtained from gas chromatography-mass spectrometry (GC-MS)-based...
DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on endothelial permeability and potential molecular mechanisms remain unclear. Hence, this study was undertaken to elucidate protective underlying vivo vitro. The results showed that could ameliorate mustard oil-induced plasma leakage skin modulate ZO-1 organization. In addition,...
Abstract Background As one of the most common intestinal inflammatory diseases, celiac disease (CD) is typically characterized by an autoimmune disorder resulting from ingesting gluten proteins. Although incidence and prevalence CD have increased over time, diagnostic methods treatment options are still limited. Therefore, it urgent to investigate potential biomarkers targeted drugs for CD. Methods Gene expression data was downloaded GEO datasets. Differential gene analysis performed...