A5040014876- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- CRISPR and Genetic Engineering
- Microfluidic and Capillary Electrophoresis Applications
- Inflammatory Biomarkers in Disease Prognosis
- Ion Channels and Receptors
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Bioactive Compounds and Antitumor Agents
- Neuropeptides and Animal Physiology
- Advancements in Photolithography Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Redox biology and oxidative stress
Peking University
2021-2025
Beijing Union University
2025
Sichuan University
2018-2022
Chengdu University
2018
Cancer progression and treatment-associated cellular stress impairs therapeutic outcome by inducing resistance. Endoplasmic reticulum (ER) is responsible for core events. Aberrant activation of sensors their downstream components to disrupt homeostasis have emerged as vital regulators tumor well response cancer therapy. Here, an orchestrated nanophotoinducer (ERsNP) results in specific ER-homing, induces hyperthermia mounting oxidative associated reactive oxygen species (ROS), provokes...
The co-administration of RDDG and RMDG NPs simultaneously inhibits the tumor growth cancer-related inflammation.
Background/Objectives: The ineffective delivery of drugs into tumors and the existence multidrug resistance (MDR) are primary causes chemotherapy failure. Downregulation Sonic Hedgehog (Shh) pathway has been shown to reduce P-glycoprotein (P-gp) expression on cell membranes resist MDR. Methods: In this study, we combine cyclopamine (CYP, a potent Shh antagonist) with paclitaxel (PTX, an antitumor drug that can produce MDR) in nano-drug system (CYP NP PTX NP) for treatment drug-resistant...
Abstract Dying tumor cells regulated by immunogenic cell death (ICD) inducers are promising candidates for cancer vaccine development because of their comprehensive antigen spectrum. However, limited immunogenicity and potential tumorigenicity hinder clinical translation. To address these challenges, a nano‐orchestrator is developed that targets the endoplasmic reticulum (ER) stress, critical pre‐ICD event, to optimize “precise dose” ER stress. Using clinical‐range irradiation fluence...