A5101993171- DNA and Nucleic Acid Chemistry
- Origins and Evolution of Life
- RNA and protein synthesis mechanisms
- Geomagnetism and Paleomagnetism Studies
- Magnetic and Electromagnetic Effects
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Microtubule and mitosis dynamics
- Molecular Sensors and Ion Detection
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Biopolymer Synthesis and Applications
- Receptor Mechanisms and Signaling
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Bee Products Chemical Analysis
- Protein Interaction Studies and Fluorescence Analysis
- Sirtuins and Resveratrol in Medicine
- FOXO transcription factor regulation
- Muscle metabolism and nutrition
- Hemoglobin structure and function
- Machine Learning in Bioinformatics
Guangxi University
2025
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2025
Qingdao Institute of Bioenergy and Bioprocess Technology
2025
Chinese Academy of Sciences
2025
Hebei Medical University
2022-2024
Fourth Hospital of Hebei Medical University
2022-2024
Imperial College London
2023
Renji Hospital
2023
Shanghai Jiao Tong University
2023
Weifang People's Hospital
2022
Mannitol is a valuable sugar alcohol, extensively used across various industries. Cyanobacteria show potential as future platforms for mannitol production, utilizing CO 2 and solar energy directly. The proof-of-concept has been demonstrated by introducing two-step pathway in cyanobacteria, converting fructose-6-phosphate to mannitol-1-phosphate sequentially mannitol. However, recombinant strains generally faced issues of genetic instability or low titers, consequently affecting the long-term...
The activities of cardiac protein kinase C (PKC) were examined in hemodynamically assessed rats subsequent to myocardial infarction (MI). Both Ca(2+)-dependent and Ca(2+)-independent PKC increased significantly left ventricular (LV) right (RV) homogenates at 1, 2, 4, 8 wk after MI was induced. also both LV RV cytosolic particulate fractions from 8-wk infarcted rats. relative contents PKC-alpha, -beta, -epsilon, -zeta isozymes homogenate, (except PKC-alpha), the failing On other hand,...
Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing control. Via directed evolution natural iron-sequestering ferritin protein, we discovered key mutations that lead to significantly enhanced cellular magnetism, resulting in increased physical attraction ferritin-expressing cells magnets contrast for resonance imaging (MRI). The mutants further demonstrate iron biomineralization measured by a...
Abstract: Although the defects in sarcolemma (SL) and sarcoplasmic reticulum (SR) membranes are known to be associated with cardiac dysfunction chronic diabetes, very little information regarding mechanisms of these membrane abnormalities is available literature. For this reason, rats were treated daily for 8 weeks without enalapril, an angiotensin‐converting enzyme inhibitor, or losartan, angiotensin receptor antagonist, 3 days after inducing diabetes injection streptozocin. Treatment...
The first example of the synthesis mono-N,O-B-chelated dipyrromethene (BODIPY) derivatives through an unexpected intramolecular nucleophilic displacement fluorine by alkenols in presence boron trifluoride as Lewis acid is reported. chlorine indacene core allowed for further structural modifications substitutions or palladium-catalysed coupling reactions to afford new fluorophores with tuneable photophysical properties. Their expanded conjugation structure resulted distinct red-shifted...
Microcephalin (MCPH1/BRIT1) is a large nuclear protein that involved in the early cellular response to DNA damage, expression of which reduced variety types human tumors. A recent study by our group demonstrated MCPH1 markedly decreased lung cancer. However, it remains unclear whether inducing may ameliorate cancer, and, if so, mechanisms underlie this process. The results present was downregulated cancer tissues compared with normal tissues. Furthermore, overexpression A549 non-small cell...
NFBD1, a signal amplifier of the p53 pathway, is vital for protecting cells from p53-mediated apoptosis and early phase DNA damage response under normal culture conditions. Here we investigated its expression in patients with nasopharyngeal carcinoma (NPC), describe biological functions NFBD1 gene. We found that mRNA protein were more highly expressed NPC tissues than nontumorous tissues. To investigate function created NFBD1-depleted cell lines exhibited decreased cellular proliferation...
Comprehensive Summary Nucleic acids are the hereditary information storage medium of life. Due to its high programmability and good biocompatibility, applications nucleic not limited their natural function. However, efficiency is often hampered by inherent limitations in numerous practical applications, including access complex functional patterns due only four building blocks, facile degradation nucleases, rapid renal clearance, poor pharmacokinetic properties, so on. To end this,...
As high-throughput biological sequencing becomes faster and cheaper, the need to extract useful information from ever more paramount, often limited by low-throughput experimental characterizations. For proteins, accurate prediction of their functions directly primary amino-acid sequences has been a long standing challenge. Here, machine learning using artificial recurrent neural networks (RNN) was applied towards classification protein function sequence without alignment, heuristic scoring...
Centromere proteins (CENPs) are a set of protein-coding genes involved in the transient assembly kinetochore which occurs during mitosis. This study intended to clarify expression patterns, prognosis and potential mechanisms CENPs breast cancer (BC).Coexpedia was used screen GEO datasets PubMed articles related BC. expressions, alteration were analyzed by Oncomine, Ualcan Kaplan Meier plotter cBioPortal. The correlation interaction performed Breast Cancer Gene-Expression Miner, GeneMANIA...
We have reported that myosin light chain phosphorylation is increased in contracting airway smooth muscle from hyperresponsive, ragweed pollen-sensitized dogs. This alteration manifest physiologically tissue sensitized animals as it demonstrates faster shortening velocity and capacity. One of the mechanisms underlying defect kinase activity; not known whether modulation phosphatase activity contributes to enhanced canine muscle. describe a assay we used compare enzyme's crude tracheal...
Abstract Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing control. Via directed evolution natural iron-sequestering ferritin protein, we discovered key mutations that lead to significantly enhanced cellular magnetism, resulting in increased physical attraction ferritin-expressing cells magnets contrast for resonance imaging (MRI). The mutants further demonstrate iron biomineralization measured...
This study aimed to investigate the role of Jumonji AT Rich Interacting Domain 2 (JARID2) in regulating triple-negative breast cancer (TNBC) stemness and its mechanism.
We reported the specific fluorescent probe (MC-BOD-XDS) with two-steps reaction based on monosulfanyl-coumarin-BODIPY for selective detection of cysteine, high activity sulfanyl-coumarin as multiple group instead a internal standard fluorophore. The mechanism MC-BOD-XDS detecting cysteine was different from probes about nucleophilic aromatic substitution (SNAr) chlorinated BODIPY. color changed yellow to red, and then orange. linear calibration diagram showed that it can potentially be used...
A competitive homogeneous quenched fluorescence assay system is described for the high throughput screening of DNA conjugates that bind to single-stranded DNA. Fluorescence signal generated by binding sample molecule a target strand labelled with quencher probe, which otherwise hybridised complementary containing fluorescent probe. Thus related affinity sample. Competitive analysis number peptide-oligonucleotide gave data correlated well corresponding UV melting data. The will be useful...
Rape pollen has always been considered as a research hotspot in health foods and pharmaceuticals due to its abundance of natural active ingredients. In this work, compound with antioxidant activity was directly isolated from the methanol extract rape using two-step procedure, under supervision online HPLC−1,1-diphenyl-2-picrylhydrazyl (HPLC-DPPH) detection. Firstly, HPLC−DPPH detection used identify peaks pollen, then pretreated via medium-pressure liquid chromatography (MPLC) obtain target...