A5100617078- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Treatment and Pharmacology
- Game Theory and Applications
- Prion Diseases and Protein Misfolding
- Distributed Control Multi-Agent Systems
- interferon and immune responses
- Extracellular vesicles in disease
- Diabetes Treatment and Management
- Evolutionary Game Theory and Cooperation
- Estrogen and related hormone effects
- Inflammasome and immune disorders
- Biopolymer Synthesis and Applications
- Pancreatic function and diabetes
- Nanocluster Synthesis and Applications
- Microbial Metabolic Engineering and Bioproduction
- Testicular diseases and treatments
- COVID-19 Clinical Research Studies
- Probiotics and Fermented Foods
- Biotechnology and Related Fields
- Mathematical and Theoretical Epidemiology and Ecology Models
Nankai University
2022-2025
Mitchell Institute
2025
Texas A&M University
2025
Affiliated Hospital of Nantong University
2022-2024
Nantong University
2022-2024
Nanjing University of Chinese Medicine
2022-2024
Chengdu Third People's Hospital
2023-2024
Anhui Medical University
2022-2024
Second Hospital of Anhui Medical University
2022-2024
Jiangxi Agricultural University
2023
Abstract N 6 -methyladenosine (m A) is an RNA modification that can be removed by demethylases [fat mass and obesity-associated protein (FTO) AlkB homolog 5 (ALKBH5)], which regulate gene expression cell function. We show m A levels m6A demethylase are altered in nasopharyngeal carcinoma (NPC) tissues vs. normal tissues. High FTO ALKBH5 predict a poor prognosis NPC patients. Silencing inhibited the malignant behavior of patient-derived cells short time. However, as time progressed,...
Urban parks have numerous environmental, social, and health benefits, yet their economic value is often underappreciated due to difficulties in quantifying these contributions. This study aims address this challenge by utilizing mobility data estimate the of recreational use city parks, focusing on Dick Nichols District Park Austin, Texas. By applying Travel Cost Method (TCM), research uses consumer surplus generated park visitors as a proxy park's from use. The analyzes visitors'...
We assessed the nearly 1-year health consequences following discharge and related risk factors of COVID-19 infection further explored long-term effect disease severity on diabetes incidence. This prospective study included 248 patients discharged from Wuhan Hospital Traditional Chinese Medicine who were followed up between 1 March 10 June 2021. Logistic regression models used to evaluate factors. The top ten symptoms shortness breath (30.3%), sore or dry throat (25.7%), cough (23.2%),...
Importance Currently, there are no treatments for nocturnal leg cramps (NLCs) that have been proven to be both safe and effective. Seeking effective approaches managing NLCs is of crucial importance. Objective To determine whether vitamin K 2 better than placebo in NLCs. Design, Setting, Participants This multicenter, double-blind, placebo-controlled randomized clinical trial was conducted China between September 2022 December 2023. study used a volunteer sample comprising community-dwelling...
The resonance light scattering intensity of gold nanoparticles which modified a prion protein (rPrP) aptamer increased after addition rPrP.
Hand knob stroke is a rare clinical disorder frequently misdiagnosed as peripheral neuropathy. The purpose of this study to recognize particular type by analyzing features, etiology, and prognosis.We enrolled 19 patients with acute hand in the Department Neurology Beijing Geriatric Hospital from January 2018 2022, imaging data during hospitalization follow-up were collected summarized.Acute accounted for 0.9% all stroke, ischemic (17 cases, 89.5%) was more than hemorrhagic (2 10.5%). All...
Abstract COVID-19, caused by the SARS-CoV-2 virus, poses significant health challenges worldwide, particularly due to severe immune-related complications. Understanding molecular mechanisms and identifying key genes (IRGs) involved in COVID-19 pathogenesis is critical for developing effective prevention treatment strategies. This study employed computational tools analyze biological data (bioinformatics) a method inferring causal relationships based on genetic variations, known as Mendelian...
Facing different environments, i.e., states, there will be game relationships among players, but also exist interactions players to form a group. This article focuses on presenting the group-based state potential (GSPG) and strongly GSPG (SGSPG) better describe such situations. Players who interact with each other can regarded as group they update strategies simultaneously. First, concept of (strongly) is given how design two kinds games shown through semi-tensor product (STP) matrices....
Abstract Background and Purpose Opioid analgesics can alleviate ischaemia/reperfusion (I/R) injury in chronic heart failure. However, the underlying mechanisms targets remain unknown. Here, we investigate if caveolin‐3 (Cav3) interacts with μ opioid receptors Cav3–μ receptor interactions play a role morphine‐induced cardioprotection failing hearts. Experimental Approach Cav3 proteins human rat tissue were determined by western blot, immunofluorescence co‐immunoprecipitation....
This brief presents the event-triggered control problem of weighted networked evolutionary games to make every player earn above a certain threshold, which will be essential for individual survive. Firstly, controls are partitioned into 'control does not work', cycle strategies' and 'normal control' three parts, algebraic form game dynamics is acquired with help semi-tensor product matrices. Secondly, two necessary sufficient conditions deduced verify existence control. Then process...
Introduction & Objective: Amylin, a hormone co-secreted with insulin from pancreatic beta-cells, reduces food intake and glucagon levels. Combination of GLP-1 amylin analogs promotes weight loss glucose control. However, treatment is complicated by the need to formulate peptides in different buffers. The objective this study was discover novel analog that could be co-formulated at neutral pH. Methods: Peptides were designed assessed for thermal-stressed stability (pH 7.4 40 oC 20 days),...
Introduction & Objective: Both GLP-1 and amylin are peptide hormones that reduce food intake, delay gastric emptying, decrease glucagon levels. Combination of analogs promotes weight loss glucose control in clinical trials. The objective this study was to assess the efficacy analog ecnoglutide (XW003) combined with novel rodent models. Methods: Amylin peptides were designed tested CHO-K1 CRE reporter cells expressing receptor complex (human calcitonin Ramp3) (AMY3) or alone (CTR)....
<title>Abstract</title> <bold>Background:</bold>COVID-19, caused by the SARS-CoV-2 virus, poses significant health challenges worldwide, particularly due to severe immune-related complications. Understanding molecular mechanisms and identifying key genes (IRGs) involved in COVID-19 pathogenesis are critical for developing effective therapeutic strategies. <bold>Methods:</bold> This study integrated bioinformatics approaches Mendelian randomization (MR) analysis elucidate roles of IRGs...
A QD labeled virus enhanced the toxicity to host cells and caused more increased release of cytokines.
Introduction Nocturnal leg cramps (NLCs) are sudden contractions of the muscles, usually in posterior calf muscles at night, affecting sleep quality. Because precise pathophysiology NCLs is unclear, different interventions have been proposed. There conflicting evidence regarding efficacy conventional preventing cramps. Thus, present study aims to investigate effects vitamin K2 for NLCs a prospective randomized, double-blind, controlled trial. Methods and analysis This multicenter,...
Yarrowia lipolytica, one of the most charming chassis cells in synthetic biology, is unable to use xylose and cellodextrins.Herein, we present work tackle for first time engineering Y. lipolytica produce lipids from cellodextrins by employing rational combinatorial strategies. This includes constructing a cellodextrin-phosphorolytic overexpressing Neurospora crassa cellodextrin transporter, Clostridium thermocellum cellobiose/cellodextrin phosphorylase Saccharomyces cerevisiae...