A5013413916- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Renin-Angiotensin System Studies
- MicroRNA in disease regulation
- Phosphodiesterase function and regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Histone Deacetylase Inhibitors Research
- E-commerce and Technology Innovations
- Dermatology and Skin Diseases
- Curcumin's Biomedical Applications
- Cancer-related Molecular Pathways
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Redox biology and oxidative stress
- Cardiovascular Disease and Adiposity
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
Nanchang Institute of Technology
2022-2024
Sichuan University
2018-2022
West China Hospital of Sichuan University
2018-2022
Hefei Normal University
2022
Southern Medical University
2022
Beijing Normal University
2021
Peking University
2012-2020
Ministry of Education of the People's Republic of China
2014
Chinese Academy of Sciences
2008
Abstract Brain disorders represent a significant challenge in medical science due to the formidable blood–brain barrier (BBB), which severely limits penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into innovative realm biomimetic nanodelivery systems, including stem cell‐derived nanoghosts, tumor cell membrane‐coated nanoparticles, and erythrocyte membrane‐based carriers, highlighting their potential circumvent BBB's restrictions. By...
Tumor-associated macrophages (TAMs) are a promising therapeutic target for cancers, but achieving multitarget therapy of TAMs is still challenging. Here, we develop protein-crowned micelle system targeted and synergistic TAM reprogramming to enhance cancer treatment. The doxorubicin-loaded micelles with hemoglobin crown (Hb-DOXM) can bind endogenous plasma haptoglobin realize specific M2-type targeting. Under the tumor hypoxic acidic environments, Hb-DOXM responsively release O2 DOX reduce...
cGMP is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides, including inosine 3',5'-cyclic monophosphate (cIMP). The present study was designed determine role of cIMP hypoxic contractions isolated porcine coronary arteries. Vascular responses were examined measuring isometric tension. Cyclic nucleotides assayed HPLC tandem mass spectroscopy. Rho kinase (ROCK)...
Colorectal cancer (CRC) is a major cause of cancer-related deaths in humans, and effective treatments are still needed clinical practice. Despite significant developments anticancer drugs inhibitors, their poor stability, water solubility, cellular membrane permeability limit therapeutic efficacy. To address these issues, multifunctional CaCO3 nanoparticles loaded with Curcumin (Cur) protein deacetylase (HDAC) inhibitor QTX125, coated hyaluronic acid (HA) (CaCO3@Cur@QTX125@HA), were prepared...
Melanoma was the most malignant skin neoplasm with an increasing morbidity around world. Although new immunotherapies and targeted therapies have emerged recently, long-term survival of melanoma patients still remains low. To reveal effective diagnostic methods therapeutic strategies, potential mechanism is urgently needed to be studied. Long non-coding RNAs (lncRNAs) become important regulatory factor in occurrence development cancer, it can used as a prognostic marker. In this study, we...
Gastric cancer (GC) is a with high mortality rate. lncRNAs play role in regulating GC tumorigenesis. In this paper, we analyzed differentially expressed between and adjacent normal tissues using multiple bioinformatics tools to identify new potential targets GC. Cell viability migration ability were detected the Counting Kit-8 (CCK-8) transwell assays, MIR4435-2HG was negatively correlated survival rate of patients, by inhibiting activity MIR4435-2HG, cells could be reduced. addition, RT-...
Soluble guanylyl cyclase (sGC) is the principal receptor for nitric oxide (NO) and crucial control of various physiological functions. The β1 subunit sGC obligatory biological stability activity heterodimer. MicroRNAs (miRNAs) are important regulators gene expression exert great influences on diverse activities. aim present study was to determine whether or not sGCβ1 specifically regulated by miRNAs. We report that miR-34c-5p directly targets under hypoxia. Bioinformatics analysis...
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of colorectal cancer (CRC) progression, but their roles and underlying mechanisms in liver metastases (CRLMs) remain poorly understood.
Abstract Astragaloside IV (AS/IV) is one of the extracted components from traditional Chinese medicine Astragalus which has been demonstrated to have potential capacity for anti-inflammation activity and treating cardiovascular disease. Our purpose was determine function underlying molecular mechanism AS/IV in hypoxia/reoxygenation (H/R) injured cardiomyocytes. Differentially expressed genes (DEGs) were screened using bioinformatic analysis, targeting relationship verified by dual-luciferase...
Abstract Background This research aimed at exploring the mechanisms of alterations metabolites and pathways in T2D from perspective metabolomics transcriptomics, as well uncovering novel drug candidate for treatment. Methods Metabolites human plasma 42 patients 45 non‐diabetic volunteers were detected by liquid chromatography‐mass spectrometer (LC‐MS). Microarray dataset transcriptome was obtained Gene Expression Omnibus (GEO) database. Kyoto Encyclopedia Genes Genomes (KEGG) database used...
Abstract Hypoxic coronary vasospasm may lead to myocardial ischaemia and cardiac dysfunction. Inosine 3′,5′‐cyclic monophosphate (cIMP) is a putative second messenger mediate this pathological process. Nevertheless, it remains unclear as whether levels of cIMP can be regulated in living tissue such artery if so, what the consequence regulation on hypoxia‐induced vasoconstriction. In present study, we found that was key determinant constriction but not subsequent relaxation response porcine...
摘要:
cGMP-dependent protein kinase (PKG) plays a crucial role in vasodilatation induced by cGMP-elevating agents. Akt has been demonstrated to be involved modulating vasoreactivity. The present study was determine the interaction between PKG and their influences on nitric oxide (NO)-induced vasodilatation. Isolated fourth-generation porcine pulmonary arteries were dissected from lung cut into rings ice-cold modified Krebs-Ringer bicarbonate buffer. relaxant responses of vessels determined organ...
We identified a Yi Chinese female patient from an ethnic minority group with methazolamide-induced toxic epidermal necrolysis. Genotyping revealed that she and her immediate family members carried the HLA-C*01:02 haplotypes, known to be associated
Myocardial injury is prone to occur during myocardial ischemia-reperfusion, which further causes adverse cardiac events. Cardiomyopeptide (CMP) has been found protect the heart against ischemia-reperfusion injury. The present study will explore molecular and signaling mechanisms associated with therapeutic effects of CMP.
Introduction: Cerebroprotein hydrolysate has been proven to improve cognitive function in patients with Alzheimer's disease (AD). We explored the safety and effectiveness of clinical administration oral cerebroprotein AD, possible mechanisms related neuronal ferroptosis pathway. Methods: Three-month-old male APP/PS1 double-transgenic mice were randomly divided into AD model (n = 8) intervention groups. Eight non-transgenic wild-type (WT) C57 used as age-matched controls. The experiments...