A5100731916- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Customer Service Quality and Loyalty
- Genomic variations and chromosomal abnormalities
- Inflammatory Biomarkers in Disease Prognosis
- Economic and Environmental Valuation
- Ocular Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Sharing Economy and Platforms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- RNA Research and Splicing
- Genomics and Rare Diseases
- Congenital heart defects research
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Single-cell and spatial transcriptomics
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Heinrich Heine University Düsseldorf
2023
Düsseldorf University Hospital
2023
Second Affiliated Hospital of Nanjing Medical University
2023
Nanjing Medical University
2023
Peking University
2020
Peking University Cancer Hospital
2020
Shandong Eye Institute & Hospital
2019
Detection of circulating cell-free DNA (cfDNA) has potential clinical value for assessing tumor biology in patients with hepatocellular carcinoma (HCC), yet many traditional assays lack robustness. This study was the first to apply a high-throughput sequencing platform detect tumor-associated mutations HCC from tumor-derived (ctDNA) and evaluate utility feasibility this approach.Using MiSeq™ system, plasma matched samples were analyzed hotspot TERT, CTNNB1, TP53 genes that had been verified...
In recent years, patients have increasing autonomy in medical decision-making. With great selecting institutions, with low-risk diseases (LRD) may opt for treatment prestigious hospitals, which limits the access of high-risk (HRD) to these hospitals. Moreover, due limited knowledge and a fear uncertainty regarding diseases, greater request various unnecessary tests alleviate their health-related anxiety. This study takes novel patients’ perspective investigate how dockless bike sharing,...
While most marketing studies have focused on what salespeople say, less is known about the persuasiveness of how they say it, particularly in distinct contexts customer acquisition and retention. This research investigates salespeople’s vocal brightness loudness influence new existing customers’ purchase behavior. Based two conducted China (a field study using a large real-world dataset over 8,000 telephone calls randomized controlled experiment), authors find that high positively predict...
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of colorectal cancer (CRC) progression, but their roles and underlying mechanisms in liver metastases (CRLMs) remain poorly understood.
Copy number variation (CNV) has become widely recognized in recent years due to the extensive use of gene screening developmental disorders and epilepsy research. 1q21.1 microduplication syndrome is a rare CNV disease that can manifest as multiple congenital disorders, autism spectrum malformations, heart defects with genetic heterogeneity.We reported pediatric patient syndrome, carried out literature review determine correlation between its phenotypes. We summarized patient's medical...
Chronic inflammation is widely recognized as a significant factor that promotes and worsens the development of malignancies, including hepatocellular carcinoma. This study aimed to explore potential role microRNAs in inflammation-associated nonresolving hepatocarcinogenesis. By conducting comprehensive analysis altered animal models with liver cancer various etiologies, we identified miR-122 most significantly downregulated microRNA animals cancer. Although previous research has indicated...
Abstract Chronic inflammation is widely recognized as a significant factor that promotes and worsens the development of malignancies, including hepatocellular carcinoma. This study aimed to explore potential role microRNAs in inflammation-associated nonresolving hepatocarcinogenesis. By conducting comprehensive analysis altered animal models with liver cancer various etiologies, we identified miR-122 most significantly downregulated microRNA animals cancer. Although previous research has...
Abstract Background Serum lipids were reported to be the prognostic factors of various cancers, but their value in malignant biliary tumor (MBT) patients remains unclear. Thus we aim assess and compare prognosis values different serum lipids, construct a novel nomogram based on lipids. Methods Patients with confirmed diagnosis MBT at our institute from 2003 2017 retrospectively reviewed. Prognosis-related identified via univariate multivariate Cox regression analyses. Then 3-tier staging...
Background: To study whether there is correlation between the expressions of Golgi protein 73 (GP73) as well signal transducer and activator transcription 3 (STAT3) prognosis in hepatocellular carcinoma (HCC) patients.Methods: Expression levels GP73 STAT3 were assessed HCC tumor tissues from those who underwent hepatectomy Peking Union Medical College Hospital. Relationships clinicopathologic features GP73/STAT3 expression analyzed by Chi-square test. Kaplan–Meier method was employed to...
BACKGROUNDIn hepatocellular carcinoma (HCC), abnormal expression of multiple microRNAs (miRNAs) has been shown to be involved in the malignant biological behavior liver cancer.The vast majority cancer cases China are closely related hepatitis B virus (HBV) infection, but there few studies on changes miRNA progression from HBV infection hepatoma. AIMTo explore role miRNAs cirrhosis and even cancer. METHODSWe screened differentially expressed 40 cirrhosis, normal 15 HCC tissues by using a...
Abstract Background The purpose of this study was to investigate the role microRNA-21 (miR-21) on bevacizumab (BEV)-induced Epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells vitro. Methods Human line (ARPE-19) were exposed clinical dosage BEV and miR-21 expression measured by qRT-PCR assay. effects BEV-induced EMT examined through gain- or loss- using mimic inhibitor. α-smooth muscle actin (α-SMA), E-cadherin, Snail, TGFβ1 smad2/3 detected western blot....