A5021958403- Research on Leishmaniasis Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- COVID-19 diagnosis using AI
- Zoonotic diseases and public health
- Biological Research and Disease Studies
- Insect and Pesticide Research
- Study of Mite Species
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Diagnosis and treatment of tuberculosis
- Rabies epidemiology and control
- Mycobacterium research and diagnosis
- Toxoplasma gondii Research Studies
- Genetic diversity and population structure
- Insect symbiosis and bacterial influences
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología
2012-2024
City of Knowledge
2014-2021
Universitat de València
2019
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019
Instituto Conmemorativo Gorgas de Estudios de la Salud
2019
Hospital General Universitario Gregorio Marañón
2019
Instituto de Biomedicina de Valencia
2019
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2019
Universidad Complutense de Madrid
2019
Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis antiviral activity evaluation of two compounds based on quinoline scaffold, which has shown potential for development molecules various biological activities. Two tested showed dose-dependent inhibition serotype 2 low sub micromolar range. The 1 were also able...
Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of ongoing disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in 1 year. The serological detection antibodies against virus will play a pivotal role complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing, and seroprevalence surveillance. Here, we aimed first evaluate lateral flow assay's ability identify specific IgM IgG...
American Tegumentary Leishmaniasis is caused by parasites of the genus Leishmania, and causes significant health problems throughout Americas. In Panama, Leishmania are endemic, causing thousands new cases every year, mostly cutaneous form. last years, burden disease has increased, coincident with increasing disturbances in its natural sylvatic environments. The study genetic variation important for a better understanding biology, population genetics, ultimately evolution epidemiology these...
Dengue virus is a growing public health threat that affects hundreds of million peoples every year and leave huge economic social damage. The transmitted by mosquitoes the incidence disease increasing, among other causes, due to geographical expansion vector's range lack effectiveness in interventions most prevalent countries. So far, no highly effective vaccine or antiviral has been developed for this virus. Here we employed phage display technology identify peptides able block DENV2. A...
COVID-19 is the name of acute respiratory disease caused by new coronavirus SARS-CoV-2, a close relative those that severe outbreaks SARS and MERS several years ago. Since first appearance on December 2019, pandemic has cause extremely high levels mortality, morbidity, global economic breakdown, consequent human suffering. The main diagnostic test for confirmation symptomatic individuals detection viral RNA reverse transcriptase-quantitative real time PCR (RT-PCR). Additionally, serology...
Systematic molecular/genomic epidemiology studies for tuberculosis surveillance cannot be implemented in many countries. We selected Panama as a model an alternative strategy. Mycobacterial interspersed repetitive unit-variable-number tandem-repeat (MIRU-VNTR) analysis revealed high proportion (50%) of Mycobacterium isolates included 6 clusters (A-F) 2 provinces (Panama and Colon). Cluster A corresponded to the Beijing sublineage. Whole-genome sequencing (WGS) differentiated due active...
The parasite Leishmania panamensis is the main cause of leishmaniasis in Panama. disease largely uncontrolled, with a rising incidence and no appropriate control measures. While microsatellites are considered some best genetic markers to study population genetics molecular epidemiology these other parasites, none has been developed for L. panamensis.Here we have tested new panel this species, based on high-throughput genome-wide screening. set composed seventeen loci, mainly spanning...
ABSTRACT Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of ongoing disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in eight months. The serological detection antibodies against virus will play a pivotal role complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing and seroprevalence surveillance. Here, we aimed first evaluate lateral flow assay’s ability identify specific...
Panama has a large number of wild animal species, which could host highly diverse amount genetic variants Toxoplasma gondii (T. gondii). In this context, we highlight the importance understanding population structure T. in Panamanian wildlife and that can be rapidly transferred to domestic environments. This study analyzed infection frequency allelic composition different tissue samples from animals. The was measured by PCR technique using B1 gene as molecular marker. results showed high...
Abstract COVID-19 is the name of acute respiratory disease caused by new coronavirus SARS-CoV-2, a close relative those that severe outbreaks SARS and MERS several years ago. Since first appearance on December 2019, pandemic has cause extremely high levels mortality, morbidity, global economic breakdown consequent human suffering. While vaccination efforts are not extensive rapid enough, main tools to keep virus under control still keeping physical distancing, reinforce personal hygiene...
AFLP is a very efficient technique for rapid detection of genetic variability, particularly useful on organisms without sequenced genomes. The objective this study was to assess the amplified fragment length polymorphisms (AFLP) testing diversity in Leishmania sp . species used were representative Viannia and subgenus. Fluorescent kits (Applied Biosystems, USA) whole procedure. Detection sizing peaks conducted with GeneMarker v. 1.91 software (Softgenetics, USA). Then error rate estimated...