A5056132189- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Bacteriophages and microbial interactions
- Radiation Effects and Dosimetry
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
Instituto de Salud Carlos III
2023
Hospital General Universitario Gregorio Marañón
2016-2021
Azienda Ospedaliero-Universitaria Careggi
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Centre National de la Recherche Scientifique
2019
CEA Paris-Saclay
2019
Université Paris-Sud
2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019
Universidad Peruana Cayetano Heredia
2019
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019
Introducción: El objetivo de este estudio fue describir la situación epidemiológica tuberculosis (TB) en España durante el año 2023 y su evolución temporal desde 2015. Método: Análisis descriptivo los casos TB notificados por las CCAA a Red Nacional Vigilancia Epidemiológica (RENAVE). Las variables analizadas fueron: sexo, edad, CCAA, país nacimiento, fecha del caso, localización, coinfección con VIH, resultado tratamiento, defunción resistencia antituberculostáticos. Se calcularon tasas...
BackgroundThe analysis of transmission tuberculosis (TB) is challenging in areas with a large migrant population. Standard genotyping may fail to differentiate within the host country from new importations, which key an epidemiological perspective.AimTo propose strategy simplify and optimise cross-border surveillance distinguish between recent importationsMethodsWe selected 10 clusters, defined by 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR),...
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular programs are lacking. A health-screening program performed arrival for inmates transferred from Peruvian Spain led diagnosis five MDR-TB cases one biggest Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 Callao-2), suggesting a reservoir prevalent MDR strains. high-rate overexposure was deduced because coinfected by pansusceptible...
Introduction: Drug resistance (DR) in Mycobacterium tuberculosis complex (MTBC) is mainly associated with certain lineages and varies across regions countries.The Beijing genotype the leading resistant lineage Asia western countries.M. (Mtb) (sub) responsible for most drug Ethiopia are not well described.Hence, this study aimed to identify sub-lineages characterize first-line anti-tuberculosis resistance-associated single nucleotide polymorphisms (SNPs).Methods: A facility-based...
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), is a chronic infectious disease with both pulmonary and extrapulmonary forms. This study set out to investigate compare genomic diversity transmission dynamics of (Mtb) isolates obtained from tuberculous lymphadenitis (TBLN) TB (PTB) cases in Northwest Ethiopia. A facility-based cross-sectional was conducted using two groups samples collected between February 2021 June 2022 (Group 1) 2020 2) Deoxyribonucleic acid...
Systematic molecular/genomic epidemiology studies for tuberculosis surveillance cannot be implemented in many countries. We selected Panama as a model an alternative strategy. Mycobacterial interspersed repetitive unit-variable-number tandem-repeat (MIRU-VNTR) analysis revealed high proportion (50%) of Mycobacterium isolates included 6 clusters (A-F) 2 provinces (Panama and Colon). Cluster A corresponded to the Beijing sublineage. Whole-genome sequencing (WGS) differentiated due active...
Abstract Background Growing international migration has increased the complexity of tuberculosis transmission patterns. Italy’s decision to close its borders in 2018 made Spain new European porte entrée for from Horn Africa (HA). In one first rescues migrants this region at end 2018, was diagnosed eight subjects, mainly unaccompanied minors. Methods Mycobacterium isolates these recently arrived were analysed by Mycobacterial Interspersed Repetitive-Unit/Variable-Number Tandem Repeat...
The assignation of lineages in Mycobacterium tuberculosis (MTB) provides valuable information for evolutionary and phylogeographic studies makes more accurate knowledge the distribution this pathogen worldwide. Differences virulence have also been found certain lineages. MTB isolates were initially assigned to based on data obtained from genotyping techniques, such as spoligotyping or MIRU-VNTR analysis, some which are suitable molecular epidemiology studies. However, since these methods...
Abstract Whole genome sequencing (WGS) is able to differentiate closely related Mycobacterium tuberculosis variants within the same transmission cluster. Our aim was evaluate if this higher discriminatory power may help identify and characterize more actively transmitted understand factors behind their success. We selected a robust MIRU-VNTR-defined cluster from Almería, Spain (22 cases throughout 2003–2019). WGS allowed discriminating, epidemiological setting, between successfully variant...
Abstract Whole genome sequencing (WGS) is able to differentiate closely related Mycobacterium tuberculosis variants within the same transmission cluster. Our aim was evaluate if this higher discriminatory power may help identify and characterize more actively transmitted understand factors behind their success. We selected a robust MIRU-VNTR-defined cluster from Almería, Spain (22 cases throughout 2003–2019). WGS allowed discriminating, epidemiological setting, between successfully variant...