A5052075700- Air Quality and Health Impacts
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality Monitoring and Forecasting
- COVID-19 Clinical Research Studies
- Emergency and Acute Care Studies
- Healthcare Quality and Management
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Heart Failure Treatment and Management
- Dialysis and Renal Disease Management
- Health disparities and outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- COVID-19 and healthcare impacts
- Migration, Health and Trauma
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Healthcare cost, quality, practices
- COVID-19 and Mental Health
- Chronic Kidney Disease and Diabetes
- Biomarkers in Disease Mechanisms
ASL Roma
2020-2024
Azienda Sanitaria Locale Roma 3
2020-2024
Agenzia Regionale Parchi
2021-2024
Regione Lazio
2020-2023
Servizio Sanitario Nazionale
2020-2023
University of Milan
2011-2021
Regional Health
2020-2021
Weatherford College
2021
Adama (Israel)
2019
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2011-2018
Circulating cardiac troponin T, a marker of cardiomyocyte injury, predicts adverse outcome in patients with heart failure (HF) but is detectable only small fraction those chronic stable HF. We assessed the prognostic value circulating T HF traditional (cTnT) and new precommercial highly sensitive assay (hsTnT).Plasma was measured 4053 enrolled Valsartan Heart Failure Trial (Val-HeFT). Troponin 10.4% population cTnT (detection limit < or = 0.01 ng/mL) compared 92.0% hsTnT (< 0.001 ng/mL)....
Epidemiology investigations have linked exposure to ambient and occupational air particulate matter (PM) with increased risk of lung cancer. PM contains carcinogenic toxic metals, including arsenic nickel, which been shown in vitro studies induce histone modifications that activate gene expression by inducing open-chromatin states. Whether inhalation metal components induces human subjects is undetermined.We investigated whether the determined activating 63 steel workers well-characterized...
Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility adverse effects PM exposure, exacerbating on diseases. Extracellular vesicles (EVs), which travel in body fluids transfer microRNAs (miRNAs) between tissues, might play an important role PM-induced risk. We sought determine whether levels aerodynamic diameter ≤ 10 μm...
ABSTRACT Cardiovascular disease risk has been consistently linked with particulate matter (PM) exposure. Cell‐derived microvesicles (MVs) are released into plasma and transfer microRNAs (miRNAs) between tissues. MVs can be produced by the respiratory system in response to proinflammatory triggers, enter circulatory remotely modify gene expression cardiovascular However, whether PM affects MV signaling never investigated. In this study, we evaluated of contained within upon exposure both vivo...
MicroRNAs (miRNAs) are environmentally sensitive inhibitors of gene expression that may mediate the effects metal-rich particulate matter (PM) and toxic metals on human individuals. Previous environmental miRNA studies have investigated a limited number candidate miRNAs not yet evaluated functional expression. In this study, we wanted to identify PM-sensitive using microarray profiling matched baseline postexposure RNA from foundry workers with well-characterized exposure PM characterize...
Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mainly caused by asbestos exposure and refractory to current therapies. Specific diagnostic markers for early MPM diagnosis are needed. Changes in miRNA expression have been implicated several diseases cancers, including MPM. We examined if a specific signature plasmatic extracellular vesicles (EV) may help discriminate between malignant pleural mesothelioma patients subjects with Past Asbestos Exposure (PAE).We investigated 23 19...
Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation emerged as a promising biomarker for cancers, including Whether exposure PM is peripheral blood leukocyte (PBL) DNA in genes not evaluated. In 63 male healthy steel workers well-characterized metal-rich nearby Brescia, Italy, we evaluated whether and metal components was PBL 4 (i.e., APC, p16, p53 RASSF1A). Blood samples were obtained on...
<h3>Objectives</h3> Recent investigations have associated airborne particulate matter (PM) with increased coagulation and thrombosis, but underlying biological mechanisms are still incompletely characterised. DNA methylation is an environmentally sensitive mechanism of gene regulation that could potentially contribute to PM-induced hypercoagulability. We aimed test whether altered mediates environmental effects on coagulation. <h3>Methods</h3> investigated 63 steel workers exposed a wide...
Despite epidemiological findings showing increased air pollution related cardiovascular diseases (CVD), the knowledge of involved molecular mechanisms remains moderate or weak. Particulate matter (PM) produces a local strong inflammatory reaction in pulmonary environment but there is no final evidence that PM physically enters and deposits blood vessels. Extracellular vesicles (EVs) their miRNA cargo might be ideal candidate to mediate effects PM, since they could potentially produced by...
Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response various stimuli. Increased body mass index (BMI) could modify the PM exposure due enhanced uptake and/or an underlying pro-oxidative state. We investigated relationship between EV release and PM10/PM2.5 cohort of 51 volunteers. Subjects were stratified based on their BMI evaluate whether...
Multiple sclerosis (MS) is a complex disorder of the central nervous system whose cause currently unknown. Evidence increasing that DNA methylation alterations could be involved in inflammatory and neurodegenerative diseases contribute to MS pathogenesis. Repetitive elements Alu, LINE-1 SAT-α, are widely known as estimators global methylation. We investigated SAT-α levels evaluate their difference case–control setup role marker disability. obtained blood samples from 51 patients 137 healthy...
Objectives Socioeconomic inequalities have a strong impact on population health all over the world. Occupational status is powerful determinant of in rich societies. We aimed at investigating association between occupation and mortality large metropolitan study. Design Cohort Setting Rome, capital Italy. Participants used Rome Longitudinal Study, administrative cohort residents 2001 general census, followed until 2015. selected aged 15–65 years baseline. For each subject, we had information...
Exposure to particulate air pollution is associated with increased blood pressure (BP), a well-established risk factor for cardiovascular disease. To elucidate the mechanisms underlying this relationship, we investigated whether effects of matter less than 10 μm in aerodynamic diameter (PM10) on BP are mediated by microRNAs. We recruited 90 obese individuals and assessed their PM10 exposure 24 48 h before recruitment day. performed multivariate linear regression models investigate BP. Using...
Epidemiological studies suggest a link between chromium (Cr) status and cardiovascular disease. Increased urinary excretion of Cr was reported in subjects with diabetes compared non-diabetic controls those insulin resistance. Epigenetic alterations have been linked to the presence Cr, microRNA (miRNA) expression has implicated pathogenesis metabolic diseases (CVDs). We investigated association miRNA leukocytes from obese subjects. also examined relationship altered selected clinical...
Objectives In this study on 90 individuals we aimed at evaluating the microRNAs (miRNAs) expression profile associated with personal levels of Titanium (Ti) and Zirconium (Zr) traced in hair samples. Ti Zr materials are broadly used for dental implants but biological reactions triggered by a long term presence these oral cavity still need to be assessed. MiRNAs mechanisms that investigated as they play fundamental role control gene following external stimuli contribute wide range...
Evidence on social determinants of health the risk SARS-CoV-2 infection and adverse outcomes is still limited. Therefore, this work investigates educational disparities in incidence mortality within 30 days onset during 2020 Rome, with particular attention to changes socioeconomic inequalities over time. A cohort 1,538,231 residents Rome 1 January 2020, aged 35+, followed from March 31 December were considered. Cumulative rates by education estimated. Multivariable log-binomial Cox...
Background/objectives: The pathologic relationship linking obesity and lipid dismetabolism with earlier onset of aging-related disorders, including cardiovascular disease (CVD) type-2 diabetes (T2D), is not fully elucidate. Chronic inflammatory state, in obese individuals, may accelerate cellular ageing. However leukocytes telomere length (LTL), the biological aging indicator, elusively linked obesity. Recent studies indicate that sterol 27-hydroxylase (CYP27A1) an emerging antiatherogenic...
Germline mutations determining increased cutaneous malignant melanoma (CMM) risk have been identified in familial and sporadic CMM cases, but they account only for a small proportion of cases. Recent evidence suggests that germline epimutations (e.g. DNA methylation alterations), which can be inherited similarly to genomic detected normal body cells (including blood), might increase susceptibility cancer. The aim the study was identify genes were found mutated (p16, p14, CDK4, MC1R, hTERT),...
Objectives to investigate the association between real estate prices, education, and mortality. Design cohort study. Setting participants residents in Rome at 2011 Italian Census, not living institutions, address reported Census survey. People aged 18-99 years were followed from 2016 using anonymous record linkage procedures with administrative databases. The includes several individual information, such as gender, age, residential neighbourhood. Data cause of death collected mortality...