A5064218551- Fatty Acid Research and Health
- Sepsis Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Synthesis and properties of polymers
- Immune Response and Inflammation
- Biomarkers in Disease Mechanisms
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Cancer therapeutics and mechanisms
- Natural Products and Biological Research
- Blood disorders and treatments
- Peroxisome Proliferator-Activated Receptors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Thyroid Disorders and Treatments
- Neonatal and Maternal Infections
- Mechanical Circulatory Support Devices
- Biopolymer Synthesis and Applications
- Cardiac Fibrosis and Remodeling
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced Polymer Synthesis and Characterization
Mario Negri Institute for Pharmacological Research
2004-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2021
New York Medical College
2007
Mylan (Switzerland)
1997-1999
Chiesi (Italy)
1998
Istituto Nazionale per le Ricerche Cardiovascolari
1992
D. Arigoni, H. R. Barton, Bernasconi, C. Djerassi, J. S. Mills and E. Wolff, Chem. Soc., 1960, 1900 DOI: 10.1039/JR9600001900
An intense systemic inflammatory response is observed following reperfusion after cardiac arrest. Heparin-binding protein (HBP) a granule released by neutrophils that intervenes in endothelial permeability regulation. In the present study, we investigated plasma levels of HBP large population patients resuscitated from out-of-hospital We hypothesized high circulating are associated with severity post-cardiac arrest syndrome and poor outcome.Plasma was obtained 278 enrolled prospective...
Attenuation of neuroendocrine activation may be beneficial in congestive heart failure. Sympathetic nervous system overactivity can reduced by receptors blockade or reducing norepinephrine (NE) spillover. This study evaluated and compared the effects a DA2-dopaminergic receptor/α2-adrenoceptor agonist (CHF-1024) β1-adrenoreceptor antagonist terms hemodynamics, ventricular remodeling, β-adrenergic drive, cardiac fibrosis after myocardial infarction (MI) rats. MI was induced left coronary...
Four derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen), in which the drug was bound by ester linkages to poly(ethylene glycols) (PEG 2000-I), monomethoxy 1900-I), poly(N-vinyl pyrrolidinone) (PVP-I) and poly(N-acryloyl morpholine) (PACM-I), all having approximatively same number average molecular weight (Mn congruent equal 2000), were prepared tested for their pharmacokinetic properties after oral administration. It found that two end-hydroxylated amphiphilic oligomers polyvinylic...
Renin-angiotensin-aldosterone and sympathetic nervous systems overactivity play a major role in worsening the extent of heart failure. Attenuation neurohumoral activation with angiotensin-converting enzyme (ACE) inhibitors β-blockers has proven beneficial congestive Because ACE inhibition is recommended treatment for failure, this study was designed to test effects on activation, hemodynamics, left ventricular (LV) volume combination an inhibitor (delapril) DA2-dopaminergic...
Inflammation and oxidative stress characterize sepsis determine its severity. In this study, we investigated the relationship between albumin oxidation severity in a selected cohort of patients from Albumin Italian Outcome Study (ALBIOS). A retrospective analysis was conducted on forms human [human mercapto-albumin (HMA), non-mercapto-albumin form 1 (HNA1) 2 (HNA2)] 60 with severe or septic shock 21 healthy controls. The were randomized (1:1) to treatment 20% crystalloid solution alone....
Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl-triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared tested for their pharmacokinetic properties after oral administration. It found that bioavailabilities decreased order, all cases lower than free drug.
Some poly(ethyleneglycol) derivatives of propranolol were prepared, in which the drug molecule was linked to oligomeric carrier via urethane bonds order study suitability this bond as a linkage between and moiety prodrugs. For comparison purposes also ethanol- butanol-based prodrugs with same promoiety. The compounds obtained by condensation N,N'carbonyldiimidazole. None these gave rise appreciable blood concentrations after oral administration, thus suggesting particular case, relative vivo...
No studies have examined the pharmacokinetics of isosorbide dinitrate (ISDN) after infusion long duration, even though such infusions are used in patients. We therefore measured ISDN and its active metabolites, isosorbide‐5‐mononitrate (IS5MN) isosorbide‐2‐mononitrate (IS2MN), plasma 9 healthy volunteers who received a continuous intravenous for 24 hours at dose rate that lowered diastolic blood pressure by 10% during first 30 minutes infusion. All subjects tolerated except one experienced...