A5023137539- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cardiac Structural Anomalies and Repair
- Renal function and acid-base balance
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Blood transfusion and management
- Anesthesia and Pain Management
- Family and Patient Care in Intensive Care Units
- Aortic Disease and Treatment Approaches
- Electrical and Bioimpedance Tomography
- Thermal Regulation in Medicine
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
Guy's and St Thomas' NHS Foundation Trust
2019-2024
St Thomas' Hospital
2020-2024
King's College London
2019-2024
Kings Health Partners
2019-2024
King's College Hospital
2022
University of Göttingen
2017-2021
NIHR Southampton Biomedical Research Centre
2020
University of Michigan
2020
University Hospital Southampton NHS Foundation Trust
2020
University of Southampton
2020
Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or use. Discriminating between these two mechanisms be relevant for the early fluid resuscitation strategy.Objectives: To understand relationship among central venous saturation (ScvO2), lactate, and base excess to better determine origin lactate.Methods: This was post hoc analysis baseline variables 1,741 patients with enrolled multicenter trial ALBIOS (Albumin Italian Outcome Sepsis)....
Abstract EDITOR’S PERSPECTIVE What We Already Know about This Topic Positive end-expiratory pressure protects against ventilation-induced lung injury by improving homogeneity of ventilation, but positive contributes to the mechanical power required ventilate Article Tells Us That Is New in vivo study (36 pigs mechanically ventilated prone position) suggests that low levels reduce associated with atelectasis, and above a threshold level power, causes adverse hemodynamics Background is usually...
The ratio of PaO2 to FiO2 (P/F) defines acute respiratory distress syndrome (ARDS) severity and suggests appropriate therapies.We investigated 1) whether a 150-mm-Hg P/F threshold within the range moderate ARDS (100-200 mm Hg) would define two subgroups that were more homogeneous; 2) which criteria led clinicians apply extracorporeal membrane oxygenation (ECMO) in severe ARDS.At threshold, patients split into mild-moderate (n = 50) moderate-severe 55) groups. Patients with (FiO2 not...
Excessive tidal volume, respiratory rate, and positive end-expiratory pressure (PEEP) are all potential causes of ventilator-induced lung injury, contribute to a single variable: the mechanical power. The authors aimed determine whether high volume or rate PEEP at iso-mechanical power produce similar different injury.Three ventilatory strategies-high (twice baseline functional residual capacity), (40 bpm), (25 cm H2O)-were each applied two levels (15 30 J/min) for 48 h in six groups seven...
In the UK, more than 279 392 cases of COVID-19 had been documented by June 3, 2020, and 39 500 patients died with disease, according to web-based dashboard at Johns Hopkins University.1Dong E Du H Gardner L An interactive track in real time.Lancet Infect Dis. 2020; 20: 533-534Summary Full Text PDF PubMed Scopus (6615) Google Scholar Data derived from UK Intensive Care National Audit Research Centre (ICNARC) Case Mix Programme Database show that, for first 8062 admitted ICU across outcomes,...
Abstract Critically ill patients with coronavirus disease 2019 (COVID‐19) present hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood analyses ( n = 3518) obtained from COVID‐19 investigate changes in haemoglobin oxygen (Hb–O 2 ) affinity. Calculated tension at half‐saturation (p 50 was on average (±SD) 3·3 (3·13) mmHg lower than the normal p value (23·4 vs. 26·7 mmHg; P < 0·0001). Compared an unmatched historic...
Quantification of potential for lung recruitment may guide the ventilatory strategy in acute respiratory distress syndrome. However, there are no quantitative data on recruitability patients with severe syndrome who require extracorporeal membrane oxygenation. We sought to quantify and its relationship outcomes this cohort patients.A single-center, retrospective, observational study.Tertiary referral failure center a university hospital United Kingdom.Forty-seven adults requiring...
Objectives: Minimally invasive extracorporeal CO 2 removal is an accepted supportive treatment in chronic obstructive pulmonary disease patients. Conversely, the potential of such technique treating acute respiratory distress syndrome patients remains to be investigated. The aim this study was: 1) quantify membrane lung (V co 2ML ) under different conditions and 2) natural 2NL what extent mechanical ventilation can reduced while maintaining total expired 2tot = V + arterial P constant....