A5013714953- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Heart Failure Treatment and Management
- Calpain Protease Function and Regulation
- Electron Spin Resonance Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Ischemia and Reperfusion
- Protein Interaction Studies and Fluorescence Analysis
Bristol-Myers Squibb (United States)
2013-2022
High density lipoprotein (HDL) cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL functionally equivalent. A primary determinant functional status is the conformational adaptability its main protein component, apoA-I, an exchangeable apolipoprotein. Chemical modification as may occur under conditions inflammation or diabetes, can severely impair function and presence disease. apoA-I also impairs ability to exchange on off HDL, a critical process...
Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting resolution by activating formyl peptide receptors (FPRs) may limit adverse progression towards heart failure. This study characterized the cellular signaling properties Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, examined whether Cmpd43 treatment improves LV infarct in rodent MI models. stimulated FPR1/2-mediated signaling, enhanced proresolution...
Heart failure with preserved ejection fraction (HFpEF) is seen more frequently in older women; risk factors include age, hypertension and excess weight. No female animal models of early stage remodelling (pre-HFpEF) have examined the effects that convergence such on cardiac structure function. In this study, we demonstrate ageing can lead to development mild chamber remodelling, diffuse fibrosis loss diastolic The oestrogens further aggravates changes by leading a notable drop output (while...
Formyl peptide receptor 2 (FPR2) plays an integral role in the transition of macrophages from a pro-inflammatory program to one that is pro-resolving. FPR2-mediated stimulation resolution post myocardial infarction has demonstrated efficacy rodent models and hypothesized reduce progression into heart failure. FPR2 agonists promote long-lasting internalization can lead persistent desensitization diminished therapeutic benefits. In vitro signaling profiles propensities for two clinically...
One of the most abundant flavonoids present in cacao is (−)-epicatechin (Epi) and this flavanol has been linked to cardiovascular health promoting actions cocoa products. We previously demonstrated that Epi reduces infarct size rodent models ischemia/reperfusion permanent coronary occlusion. Reduced was associated with decreased left ventricular (LV) oxidative stress (OS) indicators inflammation factors, which foster myocardial fibrosis. In study, we examine antifibrotic an aging female rat...
The incidence of heart failure with preserved ejection fraction (HFpEF) continues to increase and little is known about its pathophysiology. Two‐thirds HFpEF patients are senile women risk factors include hypertension metabolic syndrome. Currently, no drugs effective for treatment the development animal models would assist in novel therapy evaluation. We implemented a rodent female model aging, estrogen depletion weight gain evaluate role these altering cardiac structure/function. Female, 18...
Background The prevalence of heart failure with preserved ejection fraction (HFpEF) continues to increase and no effective therapies have been identified. Two‐thirds HFpEF patients are post‐menopausal women hypertension and/or metabolic syndrome, key factors cardiac fibrosis. goals this study were: 1) develop a rat model that displays features in humans evaluated using comprehensive panel physiological endpoints and, 2) characterize the antifibrotic potential cacao flavanol (−)‐epicatechin...