A5022384711- Bone Tissue Engineering Materials
- Advanced Chemical Physics Studies
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Atomic and Molecular Physics
- MicroRNA in disease regulation
- X-ray Spectroscopy and Fluorescence Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- MXene and MAX Phase Materials
- Atmospheric Ozone and Climate
- Advanced Drug Delivery Systems
- Cellular transport and secretion
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Connective tissue disorders research
- Electron and X-Ray Spectroscopy Techniques
- Photochemistry and Electron Transfer Studies
- Bone health and treatments
- Advanced Nanomaterials in Catalysis
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
Sichuan University
2014-2025
Wuhan University of Technology
2025
Chengdu University
2025
State Key Laboratory of Oral Diseases
2020-2024
Zhejiang University
2022-2024
Guizhou University
2024
Guiyang College of Traditional Chinese Medicine
2024
Henan Normal University
2006-2023
National Clinical Research Center for Digestive Diseases
2022-2023
University of Sheffield
2018-2023
Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for defect reconstructive treatment, especially graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol–chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the environment, ensure blood supply, promote osteogenic differentiation, accelerate reconstruction. Characterizations confirmed...
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong to tissues (up 38.72 ± 10.94 kPa). We also demonstrate mechanism relies on both physical association covalent bonding between mucus. Additionally, incorporated...
Abstract Due to their high specific surface area, graphene oxide and oxide-base nanoparticles have great potential both in dual-drug delivery combination chemotherapy. Herein, we developed cisplatin (Pt) doxorubicin (DOX) dual-drug-loaded PEGylated nano-graphene (pGO) facilitate combined chemotherapy one system. In this study, nano-sized pGO-Pt/DOX ranged around 161.50 nm was fabricated characterized using zeta-potential, AFM, TEM, Raman, UV-Vis, FTIR analyses. The drug efficacy of Pt...
Intratissue topical medication is important for the treatment of cutaneous, mucosal or splanchnic diseases. However, penetrating surface barriers to providing adequate and controllable drug delivery while guaranteeing adhesion in bodily fluids remains challenging. Here, predatory behavior blue-ringed octopus inspired us with a strategy improve medication. For effective intratissue delivery, active injection microneedles were prepared manner by teeth venom secretion octopus. With on demand...
Tough hydrogel has attracted considerable interest in various fields, however, due to poor biocompatibility, nondegradation, and pronounced compositional differences from natural tissues, it is difficult be used for tissue regeneration. Here, a gelatin-based tough (GBTH) proposed fill this gap. Inspired by human exercise improve muscle strength, the synergistic effect utilized generate highly functional crystalline domains resisting crack propagation. The GBTH exhibits excellent tensile...
Abstract Drug‐resistant bacterial infection impairs tissue regeneration and is a challenging clinical problem. Metal–organic frameworks (MOFs)‐based photodynamic therapy (PDT) opens up new era for antibiotic‐free treatment. However, the MOF‐based PDT normally encounters limited photon absorbance under visible light notorious recombination of photogenerated holes electrons, which significantly impede their applications. Herein, MOFs‐based nanosystem (AgNPs@MOFs) with enhanced response charge...
Abstract Every year, over 12 million people are enduring the persistent pain resulting from wound infections. In these chronic wounds, concealed infections may be covered up by scabs or granulation, which impeding accurate diagnosis and treatment. To address such clinical challenges, inspired corals, a biomimetic microneedle patch (HepMi‐PCL) is developed to indicate treat within wound. Relying on high‐precision 3D printing technology, each polycaprolactone own an equally sized porous shell...
This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.
Owing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction a guided regeneration membrane support vascularized remains challenge. Herein, an electrospun asymmetric double-layer polycaprolactone/collagen (PCL/Col) modified by metal-organic framework (MOF) crystals is developed. The optimization PCL/Col weight ratio (1:1 1:1.5) enables composite with balanced tensile strength (only fell 49.9% wet conditions) controlled degradation rate...
Zeolitic imidazolate framework-8 (ZIF-8) is an important type of metal organic framework and has found numerous applications in the biomedical field. Our previous studies have demonstrated that nano ZIF-8-based titanium implants could promote osseointegration; however, its osteogenic capacity related mechanisms bone regeneration not been fully clarified. Presented here a nanoscale ZIF-8 drive rat mesenchymal stem cell (rBMSC) differentiation into osteoblasts both vitro vivo, interestingly,...
Wound treatment is a long-lasting clinical issue. Poor angiogenesis leading to delayed wound closure causes huge challenges for healing. Functional electrospun membranes have been established as an efficient strategy promote recovery by protecting and improving vascular regeneration. Here, we aimed investigate the effect of tazarotene, active drug angiogenesis, loaded in aligned nanofibrous barrier on soft tissue wound. This membrane was arranged single direction, tazarotene could be...
Silk fibroin (SF) is widely used to fabricate biomaterials for skin related wound caring or monitoring, and its hydrogel state are preferred their adaptability easy use. However, in-depth development of SF restricted by limited mechanical strength, increased risk infection, inability accelerate tissue healing. Therefore, a structure-function pluralistic modification strategy using composite system metal organic framework (MOF) as bridge expanding SF's biomedical application proposed. After...
In the process of bone tissue regeneration, regulation osteogenesis-angiogenesis coupling is great importance. Therefore, dimethyloxallyl glycine (DMOG) loaded by nanoscale zeolitic imidazolate frameworks-8 (ZIF-8) to obtain a drug-loading system that can promote coupling. Characterization nanoparticles (DMOG@ZIF-8) reveals DMOG successfully into ZIF-8 two different methods, and DMOG@ZIF-8 prepared using one-pot method (OD@ZIF-8) achieves higher loading efficiency longer release time than...
Low back pain is among the most grave public health concerns worldwide and major clinical manifestation of intervertebral disc degeneration (IVDD). The destruction annulus fibrosus (AF) primary cause IVDD. A sustainable stable treatment system for IVDD lacking because special organizational structure low nutrient supply AF. We here found that results in impaired mitochondrial function AF tissue, autophagy (mitophagy) plays a protective role this process. therefore reported thread-structural...
Infectious cutaneous wounds are a thorny clinical problem. The microenvironment of the infectious wound is complicated and changes at different healing stages. Traditional treatments either have single effect such as anti-inflammation, antibacteria, or angiogenesis simple mixture several functions. They fail to deal with change physiological process, leading unsatisfactory outcomes. Herein, we designed logic-based smart nanoplatform (named ZEM), aiming self-monitor accordingly react fitting...
At present, surgery is one of the main treatments for bone tumor. However, risk recurrence and large area defects after pose a great challenge. Therefore, Janus-inspired core–shell structure scaffold was designed to achieve self-programmed release melatonin at different concentrations, clearing residual tumor cells early stage resection promoting repair later. The layered differential load designs inspired by Janus laid foundation melatonin, where sufficient inhibited growth as low dose...
In recent years, nanomaterials have gained widespread use in the biomedical field, with ZIF-8 and ZnO emerging as promising candidates due to their remarkable performance osteogenesis, angiogenesis, antimicrobial therapy. However, before advancing these for clinical applications, it is imperative evaluate biocompatibility. particular, comparing similar functions crucial identifying most suitable further development market entry. Our study aimed compare biocompatibility of nano-ZIF-8 nano-ZnO...
Body fluid environment significantly enhances bone fatigue performance. In terms of mechanics, findings reveal that, for outside the body environment, mean stress sensitivity is markedly higher than that amplitude. However, within amplitude notably affects performance only at lower levels. A model incorporating influence proposed, with characteristic parameters directly reflect intrinsic properties material based on its elastic modulus. From perspective fracture, associated initiation and...