A5076412484- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Sports injuries and prevention
- Orthopedic Infections and Treatments
- Lower Extremity Biomechanics and Pathologies
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Sports Performance and Training
- Musculoskeletal pain and rehabilitation
- Cardiovascular Effects of Exercise
- Cytokine Signaling Pathways and Interactions
- Pain Mechanisms and Treatments
- Adhesion, Friction, and Surface Interactions
- Spine and Intervertebral Disc Pathology
- Occupational Health and Performance
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Injury Epidemiology and Prevention
- Pharmacological Effects of Natural Compounds
- Musculoskeletal Disorders and Rehabilitation
- Bone and Joint Diseases
The University of Tokyo
2016-2025
University of Tokyo Hospital
2016-2024
Osaka University
2023-2024
Saitama Institute of Technology
2023-2024
Morinomiya University of Medical Sciences
2023-2024
Osaka University of Health and Sport Sciences
2024
Saitama Medical University
2024
Social Insurance Saitama Chuo Hospital
2023
John Wiley & Sons (United States)
2018-2023
Tanaka Institute of Education
2023
Osteoarthritis (OA) shows various clinical manifestations depending on the status of its joint components. We aimed to identify synovial cell subsets responsible for OA pathophysiology by comprehensive analyses human synovium samples in single-cell resolution. Two distinct tissue groups were classified gene expression profiles RNA-Seq: inflammatory and fibrotic. The group exhibited high cytokines, histologically infiltrate, a more severe pain score. fibrotic showed higher fibroblast growth...
Significance Here we demonstrate that Hes1, an important target of Notch signaling, modulated pathogenesis osteoarthritis by using Col2a1 - Cre ERT ;Hes1 fl/fl mice. Adamts5 and Mmp13 , catabolic enzymes break down cartilage matrix, were induced Hes1. Additionally, microarray analysis ChIP-seq revealed novel Hes1 genes, including Il6 Il1rl1 coding a receptor for IL-33. CaMK2δ was activated during development. formed protein complex with switched it from transcriptional repressor to activator...
Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here, we aimed elucidate the molecular mechanisms underlying relief conferred by using a mouse model of arthritis.
The purpose of this study was to examine how complications in older adults undergoing orthopaedic surgery vary as a function age, comorbidity, and type surgical procedure. We abstracted data from the Japanese Diagnosis Procedure Combination database for all patients aged ≥ 50 who had undergone cervical laminoplasty, lumbar decompression, arthrodesis, or primary total knee arthroplasty (TKA) between July 1 December 31 years 2007 2010. Outcome measures included all-cause in-hospital mortality...
Background: Previous studies have attempted to determine prognostic factors for predicting the occurrence of noncontact anterior cruciate ligament (ACL) injuries. However, on risk ACL injuries in Asian female soccer players are limited. Purpose: To identify intrinsic among young players. Study Design: Cohort study; Level evidence, 2. Methods: This study evaluated 145 Japanese potential injury during preseason medical assessment. In total, 25 variables were examined—including anthropometric...
The effect of axial rotation between the femoral neck and ankle joint (total [TR]) on normal knees is unknown. Therefore, this study aimed to investigate TR knee kinematics. Volunteers were divided into groups large (L), intermediate (I), small (S), using hierarchical cluster analysis based in standing position. was measured three-dimensional (3D) bone models generated from CT. A two-dimensional 3-dimensional registration technique used assess spatial position femur tibia orientation during...
Abstract Purpose To clarify the influence of biomechanics on post‐operative clinical outcomes in bicruciate‐retaining total knee arthroplasty (BCR‐TKA). Methods Severe medial osteoarthritis who underwent BCR‐TKA were examined. Each patient was asked to perform a squat (weight‐bearing [WB]) and active assisted flexion (non‐WB [NWB]) under single fluoroscopy surveillance. A 2D‐to‐3D registration technique used. Patients divided into two groups based their 1‐year patient‐reported outcome...
Previous studies have attempted to determine whether certain risk factors can predict the occurrence of inversion ankle sprains in male collegiate soccer players. However, no consensus has been reached on predictive sprain this population.To identify for among players.Cohort study; Level evidence, 2.Included were 145 players Japan who assessed during a preseason medical checkup potential sprain. The assessment included anthropometric measurements, joint laxity and flexibility, muscle...
Abstract A new design of the so-called “guided-motion” total knee arthroplasty (TKA) is expected to produce normal-like kinematics. The implant behaves strictly as a mechanically constraint-guided motion system. However, no previous reports have demonstrated most appropriate surgical technique or soft-tissue balance that would reproduce ideal purpose this study was clarify relationship between and intraoperative kinematics guided-motion TKA. In study, 95 patients whose TKA performed with...
Background The importance of meniscus preservation is widely recognized. There have been a few studies describing trends in meniscectomy and repair the United States; however, they presented differing results. We reported annual surgery, using national database Japan. Methods interrogated Diagnosis Procedure Combination database, which represents approximately half all hospital admissions included patients who underwent between July 2007 March 2015. diagnosis, age sex each patient were...
Objective Transient receptor potential vanilloid channel 2 (TRPV2) is a Ca 2+ ‐permeable and plays role in mediating intracellular current via mechanical stimuli. This study was undertaken to examine the expression of TRPV2 adult articular cartilage development osteoarthritis (OA). Methods We examined mouse human cartilage. analyzed OA Col2a1‐Cre ERt2 ; Trpv2 fl/fl mice littermates resection medial meniscus collateral ligament model (n = 5 each), destabilization aging 8–9 each). marker...