A5065916982- Sarcoma Diagnosis and Treatment
- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Bone Tumor Diagnosis and Treatments
- Sports injuries and prevention
- Cardiac tumors and thrombi
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Vascular Tumors and Angiosarcomas
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Orthopedic Surgery and Rehabilitation
- Cancer Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Ear and Head Tumors
- Lower Extremity Biomechanics and Pathologies
- Neurofibromatosis and Schwannoma Cases
- Inflammatory mediators and NSAID effects
- Soft tissue tumors and treatment
- Tumors and Oncological Cases
- Bone Tissue Engineering Materials
- Virus-based gene therapy research
- Orthopaedic implants and arthroplasty
- biodegradable polymer synthesis and properties
- Orthopedic Infections and Treatments
Sapporo Medical University
2016-2025
Sapporo Medical University Hospital
2022
The University of Tokyo
2017-2021
Abstract HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular are yet to be revealed. We examined HIF-1α protein the condition mouse osteoarthritis (OA) using state of art probes found that decreased as OA progressed, coinciding with change conditions cartilage. Gain- loss-of-function cell culture experiments showed suppressed catabolic genes such Mmp13 Hif2a . confirmed...
Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional induction Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting IκBα kinase (IKK) could suppress development surgically-induced OA knee in a mouse model. We employed BMS-345541 (4(2'-aminoethyl) amino-1, 8-dimethylimidazo (1,2-a) quinoxaline) as selective inhibitor subunits IKK. was created by resecting medial collateral ligament meniscus knees mice. The mice were then treated with...
Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between breakdown and repair joint tissues. Previously, we reported that Runx1 enhanced chondrogenic differentiation through transcriptional induction COL2A1, suppressed hypertrophic differentiation. Here, investigated involvement in OA development as well its potential underlying molecular mechanism. When analysed Col2a1-Cre;Runx1fl/fl Runx1fl/fl mice by surgically inducing instability, Cartilage degradation osteophyte...
Background: Each band of the deltoid ligament cooperatively contributes to stability medial side ankle joint. Investigating function each is essential assess abnormalities and develop treatment options. Purpose: To evaluate changes in kinematics when injured measure situ force ligamentous intact kinematics. Study Design: Descriptive laboratory study. Methods: A total 8 healthy fresh-frozen cadaveric legs were examined by applying forces through eversion external rotation joint using a 6...
ABSTRACT Lubricin encoded by the proteoglycan 4 (Prg4) gene is produced from superficial zone (SFZ) cells of articular cartilage and synoviocytes, which indispensable for lubrication joint surfaces. Loss-of-function human mouse Prg4 results in early-onset arthropathy accompanied lost SFZ hyperplastic synovium. Here, we focused on increases thickness Prg4-knockout joints analyzed underlying mechanisms. In late stage development, was thickened at 2 to weeks disappeared 8 mice. Similar changes...
A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about distant metastasis sparse. We evaluated the tendency and histological features in patients.Fifty-eight patients with were treated our hospitals, a total 16 consecutive metastases included this retrospective study (9 males 7 females, mean age 77 years). Because there was no patient complicated by both lung lymph node metastases, we compared age, sex, tumor size location, French Federation Cancer Centers Sarcoma...
Objective Transient receptor potential vanilloid channel 2 (TRPV2) is a Ca 2+ ‐permeable and plays role in mediating intracellular current via mechanical stimuli. This study was undertaken to examine the expression of TRPV2 adult articular cartilage development osteoarthritis (OA). Methods We examined mouse human cartilage. analyzed OA Col2a1‐Cre ERt2 ; Trpv2 fl/fl mice littermates resection medial meniscus collateral ligament model (n = 5 each), destabilization aging 8–9 each). marker...
The aims of this study were to analyse the long-term outcome vascularised fibular graft (VFG) reconstruction after tumour resection and evaluate usefulness method.We retrospectively reviewed 49 patients who had undergone a sarcoma using VFG between 1988 2015. Their mean follow-up was 98 months (5 317). Reconstruction with an osteochondral (n = 13), intercalary 12), inlay 4), or arthrodesis 20). We analysed oncological functional outcome, rate bony union complications.Five- ten-year overall...
Manual evaluation is an important method for assessing ankle instability, but it not quantitative. Capacitance-type sensors can be used to measure the distance on basis of capacitance value. We applied sensor noninvasive device measuring instability and showed its utility.First, 5 ankles embalmed by Thiel's were in experiment using a cadaver. The capacitance-type was fixed alongside anterior talofibular ligament (ATFL) specially made brace, drawer test performed. had been performed intact...
The aim of the present study was to evaluate prevalence non-ossifying fibroma (NOF) and fibrous cortical defect (FCD) in a Japanese pediatric population association between lesion size pain.This retrospective study, conducted across 10 institutions, included patients aged 5-15 years who had undergone standard antero-posterior lateral view radiography knee. Using these radiographs, we diagnosed as NOF or FCD. Patient demographics, including age, sex, location NOF, chief complaint were...
Although the minimal invasiveness of arthroscopic ankle lateral ligament repair (ALLR) means that an early return to sporting activities can be anticipated, studies have described postoperative cast immobilization and avoidance weightbearing for a certain period. Accelerated rehabilitation may helpful sport.To investigate clinical outcomes ALLR accelerated with minimum duration proactive weightbearing.Case series; Level evidence, 4.This study investigated 23 ankles 22 patients (11 men, 11...
<b><i>Objectives:</i></b> Osteosarcoma is the most common malignant bone tumor in childhood. Although a poorer prognosis has been described older patients, few reports have focused solely on primary osteosarcoma. We evaluated clinical features of elderly patients with <b><i>Materials and Methods:</i></b> Ninety-four were included this retrospective study, we divided them into 2 groups (older younger patients) based cut-off age 40 years. The...
Abstract Osteoarthritis (OA) is one of the world’s most common degenerative diseases, but there no disease-modifying treatment available. Previous studies have shown that prostaglandin E2 (PGE 2 ) and PGE2 receptor 4 (EP are involved in OA pathogenesis; however, their roles not fully understood. Here, we examined efficacy oral administration KAG-308, an EP -selective agonist, surgically induced mouse knee OA. Cartilage degeneration synovitis were significantly inhibited by KAG-308 treatment....
Studies on ankle syndesmosis have focused anterior inferior tibiofibular ligament (AITFL) and interosseous membrane injuries; however, the characteristics of posterior (PITFL) ruptures remain unclear.This study evaluated biomechanical syndesmotic instability caused by PITFL injury compared various treatment methods. We hypothesized that would lead to internal rotational stability be restored with suture tape (ST) augmentation.Controlled laboratory study.Ten uninjured fresh-frozen cadaveric...
Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis presently unknown. We retrospectively analyzed clinicopathological features 33 patients with 2001 2015. Analysis diagnosis was grouped according to presenting either <8 months (the median time from primary tumor LNM) or ≥8 after diagnosis. A relationship size not significantly found (Rs = 0.0088, p=0.96). Sixteen had an duration months, 17...
The aim of the present study was to evaluate survival impact surgical resection among patients with pulmonary metastases from bone and soft tissue sarcomas. A total 34 consecutive ≤5 sarcomas were retrospectively reviewed. included 19 men 15 women, a median age 64.0 years follow-up 14.5 months. oncological outcome compared between who underwent non-surgical treatment. 22 surgery 12 did not undergo surgery. group had 3- 5 year overall rates 62 53%, respectively. None in non-surgery survived 3...
Abstract Background The manual traditional anterior drawer test (ADT) is essential for deciding the treatment chronic ankle instability, but it has been shown to have a comparatively low reproducibility and accuracy, especially in less experienced hands. To clarify inter-examiner reproducibility, we compared actual distance of translation between junior senior examiners ADT. We also evaluated diagnostic abilities ADT, novel modified ADT (supported ADT). Methods Thirty ankles were included...
Ultrasound examinations for syndesmosis injury might be useful the quantitative evaluation of syndesmotic instability. The purpose this study was to evaluate efficacy ultrasound assessment by measuring tibiofibular distance injuries in various ligament-injured models and stress load conditions.Five normal ankles from Thiel-embalmed cadavers were used. performed placing a probe parallel with ligament running just above anterior inferior (AITFL). between border tibia fibula measured intact...