A5051450694- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Bone Tumor Diagnosis and Treatments
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Diabetic Foot Ulcer Assessment and Management
- Periodontal Regeneration and Treatments
- Cell Adhesion Molecules Research
- Musculoskeletal synovial abnormalities and treatments
- Peripheral Neuropathies and Disorders
- Congenital limb and hand anomalies
- Connective tissue disorders research
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Genetic Syndromes and Imprinting
- NF-κB Signaling Pathways
- Nerve injury and regeneration
- Autoimmune and Inflammatory Disorders Research
- Hematological disorders and diagnostics
- Heterotopic Ossification and Related Conditions
The University of Tokyo
2017-2024
Ochanomizu University
2024
Nara Medical University
2018
Abstract The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined role Runx2 and Runx3 for osteoarthritis development vivo vitro. Runx3- knockout mice exhibited accelerated following surgical induction, accompanied by decreased expression lubricin aggrecan. Meanwhile, conditional showed biphasic phenotypes: heterozygous inhibited matrix metallopeptidase 13 (Mmp13) expression, while homozygous reduced type II collagen (Col2a1)...
Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, mechanisms of ectopic association TSPCs are not yet known. Here, we investigated characteristics Prg4-positive ( + ) identified that R-spondin 2 (RSPO2), a WNT activator, specifically expressed distinct Prg4 TSPC cluster. The Rspo2 cluster was...
Abstract Background Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result exacerbation osteoarthritis (OA). Here, we examined the activity roles superficial zone (SFZ) articular cartilage. Methods was analyzed using TOPGAL mice. We generated Prg4-Cre ERT2 ;Ctnnb1 fl/fl ;Ctnnb1-ex3 fl/wt mice for gain-of-function, respectively, SFZ. Regulation Prg4 expression by vitro, as were upstream downstream factors SFZ cells. Results activity, determined reporter, high...
Clinical studies of intra-articular injection mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations pretherapeutic magnetic resonance imaging (MRI) findings with clinical outcomes up to 6 months, after administration adipose-derived (ASCs) knee OA patients.We first analyzed alterations visual analog scale (VAS) and injury outcome score (KOOS) in 57 knees 34 patients from whom scores were obtained before ASC therapy, at 1,...
ABSTRACT Lubricin encoded by the proteoglycan 4 (Prg4) gene is produced from superficial zone (SFZ) cells of articular cartilage and synoviocytes, which indispensable for lubrication joint surfaces. Loss-of-function human mouse Prg4 results in early-onset arthropathy accompanied lost SFZ hyperplastic synovium. Here, we focused on increases thickness Prg4-knockout joints analyzed underlying mechanisms. In late stage development, was thickened at 2 to weeks disappeared 8 mice. Similar changes...
Objective Transient receptor potential vanilloid channel 2 (TRPV2) is a Ca 2+ ‐permeable and plays role in mediating intracellular current via mechanical stimuli. This study was undertaken to examine the expression of TRPV2 adult articular cartilage development osteoarthritis (OA). Methods We examined mouse human cartilage. analyzed OA Col2a1‐Cre ERt2 ; Trpv2 fl/fl mice littermates resection medial meniscus collateral ligament model (n = 5 each), destabilization aging 8–9 each). marker...
There has been a paucity of literature revealing the discrepancy between self-recognition about hallux valgus (HV) and radiographically-evaluated foot configuration. Knowing this will help to make comparative review findings previous literatures epidemiological studies prevalence HV.(1) Is there radiographically-assessed self-recognized HV in general population? (2) What factors affect population?The fifth survey Research on Osteoarthritis/Osteoporosis against Disability study involved 1996...
Abstract Osteoarthritis (OA) is one of the world’s most common degenerative diseases, but there no disease-modifying treatment available. Previous studies have shown that prostaglandin E2 (PGE 2 ) and PGE2 receptor 4 (EP are involved in OA pathogenesis; however, their roles not fully understood. Here, we examined efficacy oral administration KAG-308, an EP -selective agonist, surgically induced mouse knee OA. Cartilage degeneration synovitis were significantly inhibited by KAG-308 treatment....
Abstract To investigate the trend and factors related to occurrence of osteoarthritis (OA)-like features on knee radiographs rheumatoid arthritis (RA) patients undergoing total arthroplasty (TKA) in recent decades. classify antero-posterior into ‘RA’ ‘OA-like RA’ groups, a deep learning model was developed by training network using end-stage arthropathy RA obtained during 2002–2005 primary OA 2007–2009. We used this categorize 796 radiographs, which were recorded before TKA 2006–2020,...
While ankle arthrodesis is a common treatment for severe osteoarthritis, performing bilateral controversial because of associated problems, such as gait abnormality and loss talocrural joint motion. Furthermore, few reports exist regarding the detailed outcomes arthrodesis. Therefore, we aimed to compare with those unilateral arthrodesis, using both subjective objective assessments.The data from 20 patients (10 each in groups), who underwent between 2005 2015, were retrospectively reviewed....
The effectiveness of scarf and Akin osteotomy with intra-articular lateral soft tissue release for the correction hallux valgus (HV) in patients rheumatoid arthritis (RA) has not been elucidated.A total 36 feet 28 RA who had stepwise between 2015 2020 at a single institute were investigated retrospectively, mean follow-up period 32.0 ± 16.9 months. Radiographic evaluations including HV angle, intermetatarsal sesamoid position performed preoperatively postoperatively. Clinical outcomes...
A 34-year-old woman was diagnosed with acute promyelocytic leukemia. Chemotherapy administered following the JALSG APL204 protocol. Induction therapy all-trans retinoic acid resulted in complete remission on day 49. She developed coccygeal pain from 18, which spread to spine and cheekbones lasted 5 weeks. had similar bone days 7–10 of first consolidation 4–12 second therapy. Oral loxoprofen prescribed for relief. On 33 third consolidation, white blood cell neutrophil counts were 320/ μ L 20/...
Summary: Symptomatic neuroma represents a debilitating complication after major limb amputation. The regenerative peripheral nerve interface (RPNI) has emerged as reproducible and practical surgery aimed at mitigating the formation of painful neuroma. Although previous animal studies revealed axonal sprouting, elongation, synaptogenesis proximal stump within muscle graft in RPNI, there is lack reports confirming these physiological reactions histopathological level human samples. This report...
Abstract Background Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of cells thought as promising features therapy; however, correlation between their chondrogenesis in vitro and vivo remains undefined. purpose this study was to investigate intrinsic condition depends on types explore an indicator select useful regeneration. Methods two different derived from adipose tissue (ASCs)...
Objectives: In patients with rheumatoid arthritis (RA), the talonavicular joint is commonly involved and midfoot collapse can lead to progressive flattening of arch. Despite a general awareness important structural role in foot disease, details its destructive pattern have not been elucidated. Methods: We cross-sectionally investigated 176 RA (342 feet) classified their feet into following five groups according radiographic findings: (RA changes normal navicular shape), Müller–Weiss Disease...
Dysplasia epiphysealis hemimelica (DEH), also known as Trevor's disease, is a rare overgrowth of cartilage that commonly arises in the epiphyseal bone children. We report case DEH originating from talus accompanied by multiple intra-articular free bodies 7-year-old patient with ankle instability. After primary surgery for body removal and microfracture technique defects joint, recurred. Secondary arthroscopic lateral ligament repair succeeded treating patient, without further recurrence body.
Abstract The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined role Runx2 and Runx3 for osteoarthritis (OA) development vivo vitro . knockout mice accelerated OA by surgical induction, accompanied with decreased expression lubricin aggrecan. Meanwhile, conditional showed biphasic phenotypes; was inhibited hetero-knockout matrix metallopeptidase 13 (Mmp13) expression, but homo-knockout reduction type II collagen (Col2a1)...
Intercuneiform arthrodesis is often required for various midfoot pathologies; however, intercuneiform screw insertion not easy due to the complicated anatomical structure of cuneiforms. This study aimed determine advisable entry point and direction using intraoperatively detectable landmarks. The computed tomography (CT) scan data feet were reformatted OsiriX software multiplanar reconstruction. First, based on 10 CT scans normal feet, we determined at upper one-third in dorsoplantar center...
The accessory navicular is one of the most common bones in foot, and it mostly asymptomatic. Symptomatic cases largely belong to type 2, which characterized by presence a 1-3 mm synchondrosis between large native navicular. Chronic injury considered be major cause symptoms. In this case report, we describe an uncommon avulsed 2 navicular, was dislocated level medial malleolus. A plantar slip existed naviculars, enabled patient perform active inversion but not single heel raise. collapse...
<h3>Background</h3> Despite of recent developments in therapeutic agents for rheumatoid arthritis (RA) patients<sup>[1]</sup>, it is reported that half the patients are unable to achieve remission even with existing drugs<sup>[2]</sup>. Therefore, there an urgent need gain mechanistic insight into treatment resistance. Nowadays, single-cell RNA sequencing (scRNA-seq) technology have dramatically improved our understanding heterogeneity synovial cells. However, has not been fully elucidated...