A5049581641- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Osteoarthritis Treatment and Mechanisms
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Periodontal Regeneration and Treatments
- Scoliosis diagnosis and treatment
- Hemostasis and retained surgical items
- Pelvic and Acetabular Injuries
- Mesenchymal stem cell research
- Nerve Injury and Rehabilitation
- Genetic factors in colorectal cancer
- Endometriosis Research and Treatment
- Surgical Sutures and Adhesives
- Dermatological and Skeletal Disorders
- Coastal and Marine Dynamics
- Connective tissue disorders research
- Genetic Syndromes and Imprinting
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- CNS Lymphoma Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Blood transfusion and management
The University of Tokyo
2016-2025
University of Tokyo Hospital
2021-2024
Japanese Red Cross Medical Center
2020-2021
National Hospital Organization
2013
National Disaster Medical Center
2013
Osteoarthritis (OA) shows various clinical manifestations depending on the status of its joint components. We aimed to identify synovial cell subsets responsible for OA pathophysiology by comprehensive analyses human synovium samples in single-cell resolution. Two distinct tissue groups were classified gene expression profiles RNA-Seq: inflammatory and fibrotic. The group exhibited high cytokines, histologically infiltrate, a more severe pain score. fibrotic showed higher fibroblast growth...
Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, mechanisms of ectopic association TSPCs are not yet known. Here, we investigated characteristics Prg4-positive ( + ) identified that R-spondin 2 (RSPO2), a WNT activator, specifically expressed distinct Prg4 TSPC cluster. The Rspo2 cluster was...
Dubousset et al. proposed that the "cone of economy" (COE) in inverted pendulum model human standing increases size significantly patients with balance impairment. The clinical significance COE measured by motion capture as a postural sway index adult spinal deformity (ASD) remains unclear. Twenty-three undergoing ASD surgery single institution well five healthy male participants were enrolled. motion-capture surface reflection markers above C7 and S1 spinous processes was performed using...
Abstract The impact of body mass index (BMI) on outcomes after lumbar spine surgery is currently unknown. Previous studies have reported conflicting evidence for patients with high BMI, while little research has been conducted underweight patients. This study aims to examine the BMI surgery. prospective cohort enrolled 5622 patients; which, 194, 5027, and 401 were in low (< 18.5 kg/m 2 ), normal (18.5–30), (≥ 30) groups, respectively. Pain was assessed via numerical pain rating scale...
Abstract Study design A prospective cohort study. Objectives Thrombin-gelatin matrix (TGM) is a rapid and potent hemostatic agent, but it has some limitations, including the cost its preparation time. The purpose of this study was to investigate current trend in use TGM identify predictors for usage order ensure proper optimized resource allocation. Methods total 5520 patients who underwent spine surgery multicenter group within year were included demographic factors surgical spinal levels...
Abstract Background Microendoscopic laminectomy (MEL), in which a 16-mm tubular retractor with an internal scope is used, has shown excellent surgical results for patients lumbar spinal canal stenosis. However, no reports have directly compared MEL open laminectomy. This study aimed to elucidate patient-reported outcomes (PROs) and perioperative complications undergoing versus Methods multicenter retrospective cohort of prospectively registered who underwent surgery at one the six...
Study Design Retrospective cohort study Objectives Preoperative mental state has been reported as one of the factors affecting surgical outcomes spine surgery, but few studies have examined in detail how patients’ is affected by surgery. The purpose this was to investigate using Hospital Anxiety and Depression Scale (HADS) whether surgery improves preoperative depression anxiety patients with degenerative cervical myelopathy. Methods We investigated patient-reported (Mental Component...
Although patients with diabetes reportedly have more peripheral neuropathy, the impacts of on postoperative recovery in pain and patient-reported outcome measures (PROMs) after laminoplasty for cervical spondylotic myelopathy (CSM) is not well characterized. The authors aimed to elucidate effects neck/arm/hand/leg/foot PROMs CSM. retrospectively reviewed 339 (82 257 without) who underwent between C3 C7 11 hospitals during April 2017 -October 2019. Preoperative Numerical Rating Scale (NRS)...
The aim of this study was to compare perioperative complications and postoperative outcomes between patients with lumbar recurrent stenosis without instability radiculopathy who underwent decompression surgery those fusion surgery.For retrospective study, the authors identified 2606 consecutive posterior for spinal canal at eight affiliated hospitals April 2017 June 2019. Among these patients, a history prior central restenosis cauda equina syndrome were included in study. Those or excluded....
Study design A prospective observational study. Objective To evaluate the impact on surgical outcomes of preoperative neuropathic pain (NeP) assessed by painDETECT questionnaire (PDQ) administered to participants undergoing cervical decompression surgery for degenerative myelopathy (DCM). Methods Participating patients were separated into Non-NeP group (preoperative PDQ score ≤ 12), and NeP (score ≥ 13). They asked complete a booklet questionnaire, including NRS pain, Short Form-12 PCS MCS,...
Study Design Retrospective cohort study. Objectives With the aging of Japanese population, patients with athetoid cerebral palsy (ACP) are getting older, and rate surgery for CSM is increasing in ACP patients. However, postoperative complications such among adult have not been reported yet. We investigated compared them those without using a national inpatient database Japan. Methods Using Diagnosis Procedure Combination database, we identified 61382 who underwent from July 2010 to March...
<title>Abstract</title> Ossification of the Posterior Longitudinal Ligament (OPLL) and Diffuse Idiopathic Skeletal Hyperostosis (DISH) are disorders in which patients suffer from pain stiffness due to progressive spinal fractures enthesospathy. Myelopathy impaired mobility worsen with age may progress hemiplegia; mechanisms driving disease progression unknown, effective treatments lacking. To investigate OPLL pathogenesis we prospectively quantiated plasma PPi consecutive cervical...
The surgical correction of deformities the craniovertebral junction (CVJ) remains a challenge due to its complex anatomy. Despite well-known usefulness computed tomography (CT) navigation in posterior spinal surgery, it is applied far less frequently anterior mainly registration difficulties. Case 1 was 68-year-old female with rheumatoid arthritis, complaint neck pain, motor weakness, and dysesthesia upper extremities. 2 61-year-old male Chiari malformation, pain gait disturbance after fall....
Excellent surgical outcomes of microendoscopic laminectomy (MEL) have been reported for patients with lumbar spinal canal stenosis (LSCS). However, few reports directly compared MEL open multi-level LSCS. This study conducted a comparative analysis patient-reported (PROs) and perioperative complications in undergoing two-level posterior decompression LSCS by versus laminectomy.
Background and objectives: Minimally invasive surgery has become popular for posterior lumbar interbody fusion (PLIF). Microendoscope-assisted PLIF (ME-PLIF) utilizes a microendoscope within tubular retractor procedures; however, there are no published reports that compare to open PLIF. Here we the surgical clinical outcomes of ME-PLIF with those Materials Methods: A total 155 consecutive patients who underwent single-level were registered prospectively. Of 149 complete set preoperative...
Abstract Background Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of cells thought as promising features therapy; however, correlation between their chondrogenesis in vitro and vivo remains undefined. purpose this study was to investigate intrinsic condition depends on types explore an indicator select useful regeneration. Methods two different derived from adipose tissue (ASCs)...
SUMMARY Single-cell RNA-seq (scRNA-seq) has clarified cellular heterogeneity within cell populations. However, scRNA-seq and spatial transcriptomics cannot capture the dynamic transcriptomic changes inside living cells. To decode subcellular gene expression, we developed intra-single sequencing (iSCseq), a novel approach that combines confocal imaging, repeatedly picking up components cells, next-generation (intra single-cell RNA-seq; iSCseq). iSCseq illustrated of expression. revealed not...
The prognosis of CD20-positive (CD20+) diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) recurrence is still poor. A standard treatment for CD20+ DLBCL CNS in elderly patients has not been established mainly due to adverse effects. We previously reported the efficacy and safety MIND-E (ranimustine, ifosfamide, procarbazine, dexamethasone, etoposide) therapy recurrence. Here, we report use R-MIND-E (rituximab, ranimustine, dexamethasone an patient achieved a complete...
The behaviors of hypoxic water mass in Isahaya Bay have been investigated by analyzing the data quality and wind measured from June to September 2009 Kyushu Regional Agricultural Administration Office. front responds sensitively tends be perpendicular prevailing direction. When southerly blows, low density near surface, which is rich dissolved oxygen, transported mouth seabed inner area. On other hand, northerly drifts surface area moves offshore continuous blowing decreases concentration...