A5027322897- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- HIV/AIDS drug development and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiomyopathy and Myosin Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Kruppel-like factors research
- Diabetes and associated disorders
- Antifungal resistance and susceptibility
- GDF15 and Related Biomarkers
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Drug-Induced Hepatotoxicity and Protection
Osaka University
2013-2025
Columbia University
2021-2025
Center for Digestive and Liver Diseases
2025
Nippon Medical School Musashi Kosugi Hospital
2024
Nippon Medical School
2013-2023
Kansai Medical University
2009-2022
Nippon Medical School Hospital
2022
Columbia University Irving Medical Center
2021
Kagoshima University
2017
Institute of Molecular Biology and Biophysics
2013
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent worldwide. It encompasses a spectrum ranging from simple steatosis to with hepatocellular injury, termed nonalcoholic steatohepatitis. Recent studies have demonstrated hepatic autophagy being impaired in NAFLD. In present study, we investigated impact of Rubicon, Beclin1-interacting negative regulator for autophagosome-lysosome fusion, pathogenesis HepG2 cells, BNL-CL2 and murine primary hepatocytes, Rubicon was...
Abstract Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood 1–5 . Here we demonstrate that genetic depletion HSCs changes WNT activity zonation hepatocytes, leading to marked alterations regeneration, cytochrome P450 metabolism injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator signalling, as responsible for these hepatocyte-regulatory...
β-catenin regulates the transcription of genes involved in diverse biological processes, including embryogenesis, tissue homeostasis and regeneration. Endothelial cell (EC)-specific gene-targeting analyses mice have revealed that is required for vascular development. However, precise function β-catenin-mediated gene regulation development not well understood, since only expression but also formation cell-cell junctions. To address this question, we developed a novel transgenic zebrafish line...
Abstract The fine-tuned balance between anti-apoptotic Bcl-2 family proteins, such as Bcl-xL and Mcl-1, pro-apoptotic like Bak Bax, is crucial for maintaining hepatocyte integrity. BH3-only including Bid, Bim, Puma, Noxa, Bad, Bmf, Bik Hrk, serve apoptosis initiators. They are activated by various stimuli, which leads to Bak/Bax activation. We previously reported that Bid Bim contributed through activation in the absence of proteins and/or Mcl-1. However, comprehensive involvement all eight...
Liver-specific signal transducer and activator of transcription (STAT)5-deficient mice (STAT5KO) show lipid accumulation in the liver. We investigated role hepatic STAT5 metabolism vitro vivo.High expression CD36, one receptors for free fatty acids, is associated with a high concentration triglyceride (TG) STAT5KO mice. Peroxisome proliferator-activated receptor (PPAR)γ, regulatory factors was upregulated microRNA (miR)-20b downregulated Reporter assays revealed direct regulation involving...
Summary Background and Aims Although metabolic dysfunction‐associated steatotic liver disease (MASLD) patients with a Fib‐4 index >1.3 are recommended for fibrosis evaluation via elastography or biopsy, more convenient method identifying high‐risk populations requiring follow‐up is needed. We explored the utility of serum levels growth differentiation factor‐15 (GDF15), cell stress‐responsive cytokine related to syndrome, stratifying risk clinical events in MASLD patients. Methods Serum...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic with spectrum of presentations. S100A8 has been suggested to play pivotal role as an endogenous immune-activator in inflammatory diseases. In this study, we investigated the involvement development NAFLD. We used diet model NAFLD, which mice were fed either high-fat and high-cholesterol (HFHCD) or normal (ND) control. also assessed tissues from patients including nonalcoholic (NAFL) steatohepatitis (NASH). HFHCD-fed mice, but not...
Chronic hepatitis, including viral hepatitis and steatihepatitis, is a well-known high-risk condition for hepatocellular carcinoma. We previously reported that continuous hepatocyte apoptosis drives liver tumors in hepatocyte-specific Bcl-xL or Mcl-1 knockout mice. In this study, we further examine the underlying cellular mechanisms of generating apoptosis-prone liver. cultured hepatocytes, administration ABT-737, Bcl-xL/-2/-w inhibitor, led to production reactive oxygen species (ROS) as...
A 76-year-old female with advanced renal cell carcinoma had been treated everolimus for 3 months. She visited our hospital because of a cough and fever lasting few days. Chest X-rays showed bilateral infiltrative shadows, chest computed tomography scan homogeneous ground-glass opacities mosaic patterns, especially in the apical region. The laboratory results revealed decreased white blood count lymphocytopenia high levels lactate dehydrogenase, C-reactive protein KL-6. Pneumonitis was...
Abstract Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with humanized liver to examine impact of endogenous NTCP expression on HBV infection. Upon inoculation HBV, these exhibited clear viremia in 2 weeks and serum DNA levels gradually increased. The frequency HBsAg-positive hepatocytes was 5.1 ± 0.6% at increased increasing levels, reaching 92.9 2.8% 10 12 weeks. vivo siRNA-mediated...
An intrinsic pathway of apoptosis is regulated by the B-cell lymphoma-2 (Bcl-2) family proteins. We previously reported that a fine rheostatic balance between anti- and pro-apoptotic multidomain Bcl-2 proteins controls hepatocyte in healthy liver. The homology domain 3 (BH3)-only set this toward upon activation diseased However, their involvement rheostasis remains unknown. In present study, we focused on two BH3-only proteins, Bim Bid, clarified network governs life death generated...
CD26 is a membrane glycoprotein that has multiple functions, including dipeptidyl peptidase IV activity. expression varies in different tumor types, and its role growth hepatocellular carcinoma (HCC) remains unclear.CD26 levels were examined resected HCC surrounding non-cancerous lesions. The effect of knockdown on the cellular proliferation HepG2 or Huh7 cells, both which highly express CD26, was studied vitro.CD26 mRNA significantly increased compared with their We confirmed various cell...
We herein report an autopsy case of streptococcal toxic shock syndrome with disseminated intravascular coagulation and multiple cerebral infarctions induced by Streptococcus dysgalactiae subsp. equisimilis (STSS) in 84-year-old male. Pathological examination revealed sepsis hemophagocytosis the reticular system bacteria organs, originating from bacterial necrotizing fasciitis lower extremities. The brain MRI findings showed a DWI-FLAIR mismatch, whereas pathology was almost normal, thus...
Extended-spectrum β-lactamase (ESBL)-producing-Enterobacteriaceae strains were detected in 12% (6 out of 50) fecal samples collected from the inpatients a Japanese pediatric hospital. All ESBLs belonged to CTX-M-1 group. The proportion carriage ESBL producers was higher among patients who had received antibiotics within past 3 months and those cardiologic diseases.