A5077839980- Catalysis and Hydrodesulfurization Studies
- Catalytic Processes in Materials Science
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- GDF15 and Related Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Zeolite Catalysis and Synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Chemical Synthesis and Characterization
- Electrocatalysts for Energy Conversion
- Cardiac Arrest and Resuscitation
- Pharmacy and Medical Practices
- Neuroscience of respiration and sleep
- Colorectal Cancer Surgical Treatments
- Extracellular vesicles in disease
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Heart Rate Variability and Autonomic Control
- T-cell and B-cell Immunology
- Inflammation biomarkers and pathways
- High Altitude and Hypoxia
- Peptidase Inhibition and Analysis
- Trauma and Emergency Care Studies
- Catalysis and Oxidation Reactions
Osaka University
2018-2025
ORCID
2020
Sakai Municipal Hospital
2013-2017
GlaxoSmithKline (Japan)
2017
Osaka Police Hospital
2011
Ihara Chemical Industry (Japan)
2011
Cosmo Oil (Japan)
2000-2009
National Rehabilitation Center
2008
Harvard University
2007
Introduction Coronavirus disease 2019 (COVID-19) is a new viral disease. Uncontrolled inflammation called “cytokine storm” reported to contribute pathogenesis as well sepsis. We aimed identify cytokines related the of COVID-19 through proteomics analysis 1463 plasma proteins, validate these cytokines, and compare them with Materials Methods In derivation cohort 306 patients COVID-19, unique proteins were measured on days 1, 4, 8. Cytokines associated severity prognosis derived. validation 62...
Circulating growth differentiation factor 15 (GDF-15) increases in response to inflammation and tissue damage. Its association with functional prognosis cerebral infarction subarachnoid hemorrhage is established; however, its role traumatic brain injury (TBI) relationship Sequential Organ Failure Assessment (SOFA) score, an indicator of systemic organ damage TBI, remains unclear. This study aimed explore the correlation between GDF-15 outcomes at discharge patients TBI stroke, including SOFA...
Cytokines compose a network and play crucial roles in the pathogenesis prognosis of sepsis. Adipose tissue is an important immune endocrine organ that releases adipocytokines. This study aimed to evaluate adipocytokines sepsis from perspective.This retrospective 37 patients with 12 healthy controls was conducted February 2014 July 2015. Blood samples were collected on days 1 (within 24 h diagnosis), 2, 4, 6, 8, 11, 15 controls. Adipocytokines (adiponectin, leptin, resistin, chemerin,...
Introduction Resistin is reported to form a cytokine network and cause endothelial damage. The pathogenesis of coronavirus disease 2019 (COVID-19) remains unknown, but the association between storm damage crucial. This study aimed evaluate resistin in COVID-19 compared with sepsis. Materials Methods First, we evaluated plasma levels severity clinical outcome two large cohorts: publicly available cohort including 306 patients United States (MGH cohort) our original only intubated 113 Japan...
We evaluated mRNA and miRNA in COVID-19 patients elucidated the pathogenesis of COVID-19, including protein profiles, following integration analysis. sequencing was done on admission with whole blood 5 16 healthy controls (HCs) 10 31 critically ill (derivation validation cohorts, respectively). Interferon (IFN)-α2, IFN-β, IFN-γ, interleukin-27, IFN-λ1 were measured (day 1, 181 critical/22 non-critical patients) days 6-8 (168 critical 19 HCs. In derivation cohort, 3,488 expressions identified...
Hyperglycemia is a common response to acute illness, but it not often seen in critical conditions. The frequency and cause of hypoglycemia septic patients have been well elucidated. In this study, we focused on sepsis-associated the early phase evaluated impact mortality.We performed retrospective review 265 with sepsis admitted tertiary medical center. Blood glucose levels admission were analyzed by Cox proportional hazard model.We categorized into five groups according blood levels. Seven...
Summary Background and Aims Although metabolic dysfunction‐associated steatotic liver disease (MASLD) patients with a Fib‐4 index >1.3 are recommended for fibrosis evaluation via elastography or biopsy, more convenient method identifying high‐risk populations requiring follow‐up is needed. We explored the utility of serum levels growth differentiation factor‐15 (GDF15), cell stress‐responsive cytokine related to syndrome, stratifying risk clinical events in MASLD patients. Methods Serum...
Resting memory B cells can be divided into classical or atypical groups, but the heterogenous marker expression on activated makes similar classification difficult. Here, by longitudinal analysis of mass cytometry and CITE-seq data from cohorts with COVID-19, bacterial sepsis, BNT162b2 mRNA vaccine, we observe that resting cell consist CD45RB+ CD45RBlo memory, which latter contains two distinct groups CD11c+ CD23+ non-classical cells. CD45RB levels remain stable in these after activation,...
Mo K-edge EXAFS, TEM and FT-IR of adsorbed NO were performed to further investigate the nature active sites on CoMo/HY-Al2O3 catalyst containing citric acid phosphorus, which had significantly higher HDS activity compared conventional CoMoP/Al2O3 catalyst. The results showed that new has multiple layers MoS2 slabs edges are mainly occupied by Co-Mo-S phases. XPS used sulfiding behavior Co in formation process during sulfidation. addition impregnation solution postponed sulfidation at low...
Abstract Background COVID-19 is now a common disease, but its pathogenesis remains unknown. Blood circulating proteins reflect host defenses against COVID-19. We investigated whether evaluation of longitudinal blood proteomics for and merging with clinical information would allow elucidation develop useful phenotype. Methods To achieve the first goal (determining key proteins), we derived plasma related to disease severity by using discovery cohort. then assessed association outcome in...
This study was performed to gain insights into novel therapeutic approaches for acute systemic inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against inflammation. Recent evidence suggested that transplantation of BMMNCs can reduce the tissue injury caused by regional myocardial reperfusion lung dysfunction induced lipopolysaccharides. We evaluated whether attenuate inflammatory response severe...
Our recent report showed that soluble T-cadherin promotes pancreatic beta-cell proliferation. However, how and where the secretion of is regulated remain unclear.
Acute mountain sickness (AMS) affects around 30% of people climbing Mt. Fuji, but its pathogenesis is incompletely understood. The influence a rapid ascent to high altitude by and summiting Fuji on cardiac function in the general population unknown, association with has not been clarified.Subjects were included. Heart rate, oxygen saturation, systolic blood pressure, index (CI) stroke volume measured multiple times at 120 m as baseline values Research Station (MFRS) 3,775 m. Each value...
According to guidelines from the Eastern Association for Surgery of Trauma, computed tomography (CT) with intravenous contrast is strongly recommended diagnose clinically significant blunt traumatic aortic injury (BTAI). However, it remains unclear whether timing CT scanning associated prognosis BTAI patients. We extracted data on emergency patients who suffered a in chest and/or abdomen 2004 2015 Japanese Trauma Data Bank, nationwide trauma registry. The primary outcome was death department...
Amlodipine predominantly affects vascular smooth muscle cells. overdose usually presents with vasodilatory shock, accompanied by reflex tachycardia rather than bradycardia.An 81-year-old woman presented impaired consciousness 8 h after ingesting 50 5-mg amlodipine tablets suicidal intent. On admission, her blood pressure was 50/40 mmHg and heart rate 45 b.p.m. Serum level extremely high (474.4 ng/mL), causing refractory bradycardia. She remained hypotensive despite fluid resuscitation,...