Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on mortality and ventilator-free days have not been well studied among with sepsis.To examine whether a strategy dexmedetomidine can improve clinical outcomes in sepsis ventilation.Open-label, multicenter randomized trial conducted at 8 intensive care units Japan from February 2013 until January 2016 201 consecutive adult requiring mechanical ventilation least 24 hours.Patients were to receive either...

Background This study was undertaken to define the factors that affected final outcome of trauma patients in Hanshin-Awaji earthquake. Methods Medical records admitted 95 hospitals within or surrounding area during first 15 days after quake were reviewed. Results There 2,702 traumatized patients. One-third transported and had a mortality rate 3%. The remainder, who treated hospitals, showed significantly higher (8%; p < 0.05). Intensive care provided for 513 patients, most whom suffered from...

Introduction Coronavirus disease 2019 (COVID-19) is a new viral disease. Uncontrolled inflammation called “cytokine storm” reported to contribute pathogenesis as well sepsis. We aimed identify cytokines related the of COVID-19 through proteomics analysis 1463 plasma proteins, validate these cytokines, and compare them with Materials Methods In derivation cohort 306 patients COVID-19, unique proteins were measured on days 1, 4, 8. Cytokines associated severity prognosis derived. validation 62...

Abstract Background Administration of dexmedetomidine has been reported to improve inflammatory response in animals. We explored the effects administering on levels C-reactive protein (CRP) and procalcitonin, thus inflammation, patients with sepsis enrolled a randomized clinical trial. Methods The DESIRE trial was multicenter which adult were sedated (DEX group) or without (non-DEX while mechanical ventilators. As prespecified sub-analysis, we compared CRP procalcitonin during first 14 days...

Abstract Background Dexmedetomidine has been reported to improve organ dysfunction in critically ill patients. In a recent randomized controlled trial (Dexmedetomidine for Sepsis Intensive Care Unit (ICU) Randomized Evolution [DESIRE]), we demonstrated that dexmedetomidine was associated with reduced mortality risk among patients severe sepsis. We performed this exploratory sub-analysis examine the mechanism underlying improved survival sedated dexmedetomidine. Methods The DESIRE compared...

Abstract To obtain more useful information about the effect of degree stereoregularity on motion polymer chain, dielectric and dilatometric measurements were made for a series stereoregular poly(methyl methacrylates) (PMMA). The α‐ β‐absorptions observed in each sample, which behaviors α‐process are discussed. temperature dependence relaxation time was sufficiently represented by WLF equation resulting values parameters f g B modified found smaller isotactic‐rich PMMA than those syndiotactic...

Smoke-inhalation injury is a major cause of mortality in burn patients, and therefore, it important to determine accurately the severity such injuries these patients. The objective this study was evaluate whether chest computed tomography (CT) can be used for detecting early predictors complications smoke-inhalation injury.We evaluated 37 patients who had sustained undergone CT within few hours admission hospital. Bronchoscopy performed according standardized protocol 12 all Bronchial-wall...

Introduction Resistin is reported to form a cytokine network and cause endothelial damage. The pathogenesis of coronavirus disease 2019 (COVID-19) remains unknown, but the association between storm damage crucial. This study aimed evaluate resistin in COVID-19 compared with sepsis. Materials Methods First, we evaluated plasma levels severity clinical outcome two large cohorts: publicly available cohort including 306 patients United States (MGH cohort) our original only intubated 113 Japan...

Lactate clearance is useful to guide initial resuscitation of patients with septic shock. We conducted this study evaluate whether dexmedetomidine increases lactate in This was a randomized controlled trial that involved post hoc subgroup analysis. Adult shock under ventilation were receive sedation strategy or without (60 the and 51 nondexmedetomidine groups). The primary outcome at 6 h, defined as percent decrease from randomization h after. median Acute Physiology Chronic Health...

Background: Dose and injection times have not previously been determined for subcutaneously administered recombinant human erythropoietin that would allow sufficient deposition of blood autologous use in cardiac surgery. Study Design Methods: A double‐ blind, multicenter trial placebo (Group 1) at 12,000 IU 2) 24,000 3) was performed on 114 patients 26 institutions to determine the dosage permit an 800‐g preoperative deposit use. The test drug Days 21, 14, 7 prior operation, oral iron...

Neurological abnormalities are a key factor in the prognosis of patients with post-cardiac arrest syndrome. In this study, we evaluated whether differences CT measurements expressed Hounsfield units (HUs) cerebral cortex and white matter can be used as early predictors neurological outcome treated hypothermia therapy after hypoxic-ischemic brain damage. We performed retrospective study 58 resuscitated cardiac between 2007 2010 who were for initial 24 hours post resuscitation. divided into 4...

Abstract Objectives After the 2011 Great East Japan Earthquake, resource utilization of and problems encountered with communication devices were examined. Methods A questionnaire survey was submitted to disaster medical assistance teams (DMATs) that at primary sites destruction after earthquake. Results We collected data from 196 teams. During first 4 days earthquake, use mobile phones, laptop computers, landline phones rated as poor moderate, satisfaction very low, while satellite good...

We experienced four Japanese patients with spontaneous retroperitoneal bleeding, a rare disease. categorized the clinical characteristics of bleeding in these treated our hospital and discuss risk factors bleeding.Three 4 did not have tendency as indicated by laboratory data obtained at time bleeding. The causative blood vessels were lumbar superior gluteal arteries internal iliac artery. All receiving an anticoagulant, heparin one nafamostat mesilate other three patients. Three being...

Use of high-dose norepinephrine is thought to have an immunosuppressive action that increases mortality. This study aimed evaluate the correlation between dosage and prognosis patients with septic shock.This was a nested cohort DExmedetomidine for Sepsis in Intensive Care Unit Randomized Evaluation (DESIRE) trial. We evaluated 112 shock initial Sequential Organ Failure Assessment Cardiovascular (SOFA-C) category score > 2 lactate level mmol/L. divided into two groups according administered...

Background: Ketone bodies have been considered as a means of providing energy because their good penetration and rapid diffusion in peripheral tissues. However, the currently available form 3‐hydroxybutyrate is sodium salt, load problematic. To avoid it, mixture dimer trimer has prepared precursor D‐3‐hydroxybutyrate. The purpose this study was to investigate whether how solution would be converted monomers. Methods: plasma concentration monomer measured 10 rats during infusion trimer....

Objective To clarify clinical features and determine the severity of injuries in patients with crush syndrome Hanshin-Awaji earthquake. Methods We retrospectively reviewed medical records 6,107 hospitalized 95 hospitals, identified 372 syndrome. Results The major sites injury were lower extremities (74%), followed by upper (10%), trunk (9%). Pelvic fractures, limb abdominal most frequently associated injury. Patients compression and/or had a higher mortality rate. A total 50 (13.4%) died....

Bicycle accidents are one of the major causes unintentional traumatic injury in childhood. The purpose this study was to examine characteristics and risks handlebar We conducted a more than 5-year retrospective survey patients under 15 years age with bicycle-related injuries admitted eight urban tertiary emergency centers Osaka, Japan. Patients were divided into direct-impact (HI) group non-handlebar (NHI) group. HI included 18 NHI 308 patients. Median Injury Severity Score (ISS) 9. sites...

&lt;b&gt;&lt;i&gt;Background/Aims:&lt;/i&gt;&lt;/b&gt; The optimal duration of hemoperfusion therapy with a polymyxin B-immobilized fiber column has not yet been verified. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This analysis examined whether lasting longer than 2 h (prolonged polymyxin) improved outcomes for patients septic shock compared to 2-h (sub-analysis data from the DESIRE trial). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; and prolonged groups contained 22 14 patients,...

Abstract The sorption properties of atactic polypropylene (APP) and isotactic (IPP) were studied by equilibrium various organic solvents. variation the Flory‐Huggins interaction parameter χ for APP‐CCl 4 system at 25°C was expressed as a function volume fraction v 2 polymer relation: x = 0.113 exp {1.879 }. average molecular weight M c chains between successive crystallites IPP subjected to different thermal treatments calculated be 250 350 equation Flory Rehner. From with solvent...

Abstract The pure quadrupole spectra of 2,5-dichloroaniline and 2,5-dichloronitrobenzene were observed at room temperature (292°K), the effects electron releasing or attracting power amino- nitro-group in benzene ring compared with each other. On other hand, a linear relation between resonance absorption frequencies due to Cl35 Hammett’s σ substituents these compounds was found, o-amino-group assumed be −0.26. We are indebted Prof. T. Ichikawa D. Nakae for their generarity granting us use...