A5008918203- Burn Injury Management and Outcomes
- MicroRNA in disease regulation
- Thermal Regulation in Medicine
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Electromagnetic Fields and Biological Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Chemical and Physical Studies
- Advanced Fluorescence Microscopy Techniques
- Nonlinear Optical Materials Studies
- Injury Epidemiology and Prevention
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- Erythrocyte Function and Pathophysiology
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Transport and Resistance Mechanisms
- Magnetic and Electromagnetic Effects
- Pneumonia and Respiratory Infections
- Abdominal Trauma and Injuries
Osaka University
1986-2025
Chukyo Hospital
2013-2024
Yamaguchi University
2018-2020
Japan Community Healthcare Organization
2015
Fukushima Medical University
1986
Protection against endothelial damage is recognized as a frontline approach to preventing the progression of cytokine release syndrome (CRS). Accumulating evidence has demonstrated that interleukin-6 (IL-6) promotes vascular during CRS, although molecular mechanisms remain be fully elucidated. Targeting IL-6 receptor signaling delays CRS progression; however, current options are limited by persistent inhibition immune system. Here, we show trans-signaling promoted and inflammatory responses...
Community-acquired pneumonia is an acute lung infection in patients without recent healthcare exposure that can progress to severe sepsis. Despite the well-established influence of miRNAs on inflammation, their specific roles pneumonia-associated sepsis remain underexplored. In this pilot study, we aimed provide insights into pathogenesis community-acquired by performing integrative mRNA-miRNA analysis identify key cellular signaling pathways and potential molecular targets for future...
Recent studies suggest the linkage of hypertension and insulin resistance. High fructose diet is known to induce hyperinsulinemia in rats. In a previous study, however, high (66%) failed elevate blood pressure but increased left ventricular weight Sprague-Dawley present we investigated precise mechanism diet-induced changes cardiovascular system Intake fructose-enriched for 2 weeks serum plasma angiotensin II levels. Urinary excretion sodium norepinephrine was not changed. Blood measured...
Introduction Resistin is reported to form a cytokine network and cause endothelial damage. The pathogenesis of coronavirus disease 2019 (COVID-19) remains unknown, but the association between storm damage crucial. This study aimed evaluate resistin in COVID-19 compared with sepsis. Materials Methods First, we evaluated plasma levels severity clinical outcome two large cohorts: publicly available cohort including 306 patients United States (MGH cohort) our original only intubated 113 Japan...
Resting memory B cells can be divided into classical or atypical groups, but the heterogenous marker expression on activated makes similar classification difficult. Here, by longitudinal analysis of mass cytometry and CITE-seq data from cohorts with COVID-19, bacterial sepsis, BNT162b2 mRNA vaccine, we observe that resting cell consist CD45RB+ CD45RBlo memory, which latter contains two distinct groups CD11c+ CD23+ non-classical cells. CD45RB levels remain stable in these after activation,...
Aim For patients with inhalation injury, the indications for early intubation are diverse. The purpose of this study was to identify most reliable symptoms, physical findings, and medical examinations which determine in injury. Methods We retrospectively collected patient data from records. Collected included age, sex, burn size, carboxyhemoglobin levels ( COH b), bronchial wall thickness BWT ) determined chest computed tomography images. analyzed relationships between these findings...
Background Acute respiratory distress syndrome (ARDS) is failure that commonly occurs in critically ill patients, and the molecular mechanisms underlying its pathogenesis severity are poorly understood. We evaluated mRNA miRNA patients with ARDS elucidated of after performing integration analysis. Methods In this single-center, prospective, observational clinical study ARDS, peripheral blood each patient was collected within 24 hours admission. Sequencing performed using whole from healthy...
Abstract Aim This study investigated whether contrast extravasation on computed tomography (CT) angiography in patients with traumatic brain injury (TBI) is associated death or surgical procedures. Methods Patients over 18 years old, directly brought by ambulance an isolated head and confirmed to have acute intracranial hemorrhage a CT scan upon admission between 2010 2020, were included. The primary outcome was mortality, the secondary neurosurgical procedures performed from discharge...
Abstract Immune responses that occur following burn injury comprise a series of reactions are activated in response to damaged autologous tissues, followed by removal tissues and foreign pathogens such as invading bacteria, tissue repair. These immune considered be programmed living organisms. Developments modern medicine have led the saving burned patients who could not cured previously; however, is no longer able keep up, various problems arisen. This paper describes mechanism specific...
This study aimed to comprehensively compare host responses of patients with bacterial sepsis and those viral (COVID-19) by analyzing messenger RNA (mRNA) microRNA (miRNA) profiles shed light on their distinct pathophysiological mechanisms.
Extravascular leakage on computed tomography (CT) angiography in patients with traumatic brain injury (TBI) is associated hematoma expansion, functional prognosis, subsequent surgery, and death. Fresh frozen plasma (FFP) administration often necessary to treat coagulation disorders TBI. This study aimed determine the relationship between presence of extravascular contrast-enhanced head CT, fibrinogen level at admission, FFP The medical records TBI ≥18 years age referred our hospital January...
A renin-producing juxtaglomerular cell tumor was found in a 27 year-old woman. The infusion of angiotensin II analogue produced marked decrease arterial pressure. Oral administration captopril also reduced her blood Although the renal vein renin did not indicate laterality tumor, unilateral partial nephrectomy cured disease. This is first case report to describe measurement several hemodynamic parameters before and after surgical removal tumor.
Recent advancements in proteomics allow for the concurrent identification and quantification of multiple proteins. This study aimed to identify proteins associated with severe burn pathology establish a clinically useful molecular classification. In retrospective observational study, blood samples were collected from patients. Proteins measured using mass spectrometry, prognosis-related extracted by comparing survivors non-survivors. Enrichment ROC analyses evaluated proteins, followed...
Case We describe a patient with severe pancreatitis and ischemic colitis after extensive burn injury. An 81-year-old man presented 55% total body surface area inhalation A low-density was detected in the pancreas on abdominal computed tomography scan admission. The clinical course of good until 28 days injury when he complained pain distension. Abdominal revealed acute colitis. Outcome died 59 Conclusions Extensive can cause pancreatitis. Further work-up is necessary to identify pancreatic...
<title>Abstract</title> Resting memory B-cells can be divided into classical and non-classical groups based on differential expression of markers such as CD27 CD11c, while activated express a combination markers, making their ontogeny hard to determine. Here by longitudinal analysis COVID-19, bacterial sepsis, BNT162b2 mRNA vaccine recipients mass cytometry CITE-seq we describe three-branch structure resting B-cell consisting “classical” CD45RB<sup>+</sup> two branches CD45RB<sup>lo...
ABSTRACT Background: Growth differentiation factor-15 (GDF-15) is expressed in almost all tissues of the body and necessary for body's defense response to stress such as inflammation. It has been reported be associated with incidence mortality many diseases, including systemic inflammatory syndromes. There are no reports on GDF-15 burns. The purpose this study was investigate trend blood patients severe burns determine its relationship severity mortality. Methods: This a retrospective,...
By employing an Yb-doped femtosecond fiber laser oscillating at 1030 nm, multi-photon fluorescence microscopy imaging was demonstrated, utilizing competitive two- and three-photon absorption processes for excitation of the probes. Competitive absorptions occurred all six probes employed. The mitochondria human embryonic kidney 293 cells were stained with probes, images obtained in cases. brightest image when probe compound possessing longest cut-off wavelength. This can be attributed to...
The purpose of this study is to demonstrate the efficacy our novel hemostatic technique for burn surgery. Significant bleeding remains a challenge in tangential excision wound. Although various techniques reduce intraoperative blood loss have been described, there an absence uniformity and consistency their application. In literature, surgery estimated be at least 123 ± 106 ml per percentage body surface area excised [1]. Recently we developed using silicone gel dressing (SI-AID®; ALCARE...