A5102836123- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Diet and metabolism studies
- Obstructive Sleep Apnea Research
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Non-Invasive Vital Sign Monitoring
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Infectious Diseases and Mycology
- Mycobacterium research and diagnosis
- Cardiovascular and Diving-Related Complications
- Ultrasound in Clinical Applications
- Autopsy Techniques and Outcomes
- Thermal Regulation in Medicine
- Restless Legs Syndrome Research
- Vascular Tumors and Angiosarcomas
- Blood properties and coagulation
- Cancer, Lipids, and Metabolism
- Bone fractures and treatments
Japan Anti Tuberculosis Association
2011-2025
Fukujuji Hospital
2012-2025
Alberta Hospital Edmonton
2024
Nippon Medical School
2010-2022
Chukyo Hospital
2014
Saitama Medical University
2013
A new loop-mediated isothermal amplification (LAMP) test kit, including a simple DNA extraction device for the detection of Mycobacterium tuberculosis complex, was developed commercial use and evaluated its usefulness in diagnosing (TB).The LAMP performed using untreated N-acetyl-L-cysteine (NALC) NaOH-treated sputum specimen. The efficiency kit compared with other conventional laboratory examinations, nucleic acid (NAA) tests.The sensitivity raw (direct LAMP) smear- culture-positive...
To quantitatively compare diaphragmatic motion during tidal breathing in a standing position between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography.Thirty-nine COPD (35 males; age, 71.3±8.4years) 47 (non-smoker healthy volunteers) (20 54.8±9.8years) underwent sequential radiographs radiography with flat panel detector system. We evaluated the excursions peak speeds of diaphragms. The results were analyzed an unpaired t-test multiple...
Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived produced high EPS...
Pulmonary Mycobacterium avium complex (MAC) disease is the most common pulmonary non-tuberculous mycobacteriosis (NTM). The clinical and radiological findings were similar to those of tuberculosis, both which are characterized by upper lobe cavities. On other hand, presence middle lower field lesions with centrilobular nodules bronchiectasis has been noted. We analyzed feature these two radiologically different types identified their prognostic factors.The clinical, laboratory 273 cases MAC...
<h3>Rationale and Objectives</h3> Diaphragmatic motion in a standing position during tidal breathing remains unclear. The purpose of this observational study was to evaluate diaphragmatic health screening center cohort using dynamic chest radiography association with participants' demographic characteristics. <h3>Materials Methods</h3> One hundred seventy-two subjects (103 men; aged 56.3 ± 9.8 years) underwent sequential radiographs flat panel detector system. We evaluated the excursions...
To assess diaphragmatic motion during forced breathing in a health screening center cohort by time-resolved quantitative analysis using dynamic chest radiography and demonstrate the characteristics associations with demographics pulmonary function of participants.This prospective study includes 174 volunteers (99 males; median 57, range 36-93 years old) that underwent flat panel detector system standing position. We automatically tracked recorded positions top diaphragms excursions on images...
Dynamic X-ray (DXR) provides images of multiple phases breath with less radiation exposure than CT. The exact at end-inspiratory or end-expiratory can be chosen accurately.To investigate the correlation projected lung area (PLA) by dynamic chest pulmonary functions.One hundred sixty-two healthy volunteers who received medical check-ups for health screening were included in this study. All subjects underwent DXR both posteroanterior (PA) and lateral views function tests on same day. took...
Statins are the first-line agents used to treat patients with high serum low-density lipoprotein cholesterol levels, thus reducing risk of death from arterial sclerotic cardiovascular disease; however, little is known about effects non-statin pharmacological interventions on mortality as well potential protective statin use against cancer death. This work aimed compare all-cause and among hyperlipidaemia who did not receive treatment.Between 2003 2007 fiscal years, we recruited Japanese...
The incidence of nontuberculous mycobacterial pulmonary disease (NTMPD) is increasing worldwide. Secondary spontaneous pneumothorax occurs as a complication underlying lung and associated with higher morbidity, mortality, recurrence than primary pneumothorax. We here investigated the clinical features long-term outcomes NTMPD. conducted retrospective study on consecutive adult patients NTMPD at Fukujuji Hospital Keio University from January 1992 to December 2013. reviewed medical records 69...
ObjectivesTo compare the craniocaudal gradients of maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography.Materials methodsThis prospective study was approved by institutional review board all participants provided written informed consent. Forty-three COPD (mean age, 71.6 ± 8.7 years) 47 (non-smoker healthy volunteers) 54.8 9.8 underwent sequential radiographs in a...
Peroxiredoxin (Prx) 2 in red blood cells (RBCs) reacts with various reactive oxygen species and changes to hyperoxidized Prx2 (Prx2-SO2/3). Therefore, may serve as an indicator of oxidative stress vivo. This study aimed analyze Prx2-SO2/3 levels clinical samples examine whether the oxidation state human RBCs reflects pathological condition diseases. We first focused on obstructive sleep apnea (OSA), a hypoxic stress-induced disease respiratory system, investigated accumulated OSA patients....
The identification and appropriate management of commercial motor vehicle (CMV) drivers with unrecognized obstructive sleep apnea (OSA) is a major public health concern priority; OSA among has not been fully investigated in Japan, better understanding this undiagnosed disease warranted. Therefore, we evaluated the prevalence factors related to apnea-hypopnea index (AHI) Japanese CMV drivers.
Abstract Background We assessed the difference in lung motion during inspiration/expiration between chronic obstructive pulmonary disease (COPD) patients and healthy volunteers using vector-field dynamic x-ray (VF-DXR) with optical flow method (OFM). Methods enrolled 36 COPD 47 volunteers, classified according to function into: normal, mild, severe. Contrast gradient was obtained from sequential (DXR) converted vector OFM. VF-DXR images were created by projection of vertical component...
Objectives: To explore the feasibility of Vector-Field DXR (VF-DXR) using optical flow method (OFM). Methods: Five healthy volunteers and five COPD patients were studied. was performed in standing position a prototype X-ray system (Konica Minolta Inc., Tokyo, Japan). During examination, participants took several tidal breaths one forced breath. image file converted to videos with different frames per second (fps): 15 fps, 7.5 three 1.5 fps. Pixel-value gradient calculated by serial change...
Introduction: Patients with brain metastases have commonly been denied bevacizumab treatment because of the suspected risk central nervous system (CNS) hemorrhage. Although safety information on non-small-cell lung cancer (NSCLC) CNS has accumulated, its use is still controversial. We conducted present retrospective study to investigate in patients NSCLC and metastases.Methods: Clinical data treated chemotherapy regimens containing a single institution from Feb. 2010 Nov. 2011 were assembled...
Abstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS)-short-chain fatty acid (SCFA)-carbohydrate metabolic axis. Healthy human donor-derived produced high EPS levels but...
The purpose of this study is to demonstrate the efficacy our novel hemostatic technique for burn surgery. Significant bleeding remains a challenge in tangential excision wound. Although various techniques reduce intraoperative blood loss have been described, there an absence uniformity and consistency their application. In literature, surgery estimated be at least 123 ± 106 ml per percentage body surface area excised [1]. Recently we developed using silicone gel dressing (SI-AID®; ALCARE...