A5105309639- Gut microbiota and health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
The Abdus Salam International Centre for Theoretical Physics (ICTP)
2025
Hokkaido University
2024-2025
Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived produced high EPS...
HTLV-1-associated myelopathy (HAM) develops in a part of HTLV-1-infected individuals while most the remain asymptomatic. This complicates identification HTLV-1 carriers at elevated risk. In this study, we integrated proviral load and antibody titers against Tax, Env, Gag p15, p19, p24 proteins machine learning (ML) framework to identify characterize high-risk likely develop HAM. We stratified asymptomatic carrier samples employing an anomaly detection model. further developed validated...
Abstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS)-short-chain fatty acid (SCFA)-carbohydrate metabolic axis. Healthy human donor-derived produced high EPS levels but...