A5026182793- Gut microbiota and health
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Birth, Development, and Health
- RNA modifications and cancer
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Drug Transport and Resistance Mechanisms
- Biochemical Analysis and Sensing Techniques
- Gastroesophageal reflux and treatments
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Fatty Acid Research and Health
- Cancer Risks and Factors
- Pregnancy and preeclampsia studies
- Amino Acid Enzymes and Metabolism
Kyoto University
2020-2025
Kyoto Pharmaceutical University
2023-2024
Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. are by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, exact mechanism these remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) substantial host metabolic benefits. EPS is an indigestible α-glucan, and intake purified form improved...
The global dietary supplement market is valued at over USD 100 billion. One popular supplement, S-adenosylmethionine, marketed to improve joints, liver health and emotional well-being in the US since 1999, has been a prescription drug Europe treat depression arthritis 1975, but recent studies questioned its efficacy. In our body, S-adenosylmethionine critical for methylation of nucleic acids, proteins many other targets. marketing SAM implies that more better it would stimulate methylations...
Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived produced high EPS...
GPR164 is a novel free fatty acid receptor, activated by both short-chain acids and medium-chain acids, expressed throughout the gastrointestinal tract. Although reported to be involved in release of gut hormones, physiological functions this receptor maintenance intestinal homeostasis remain unclear. In study, we explored role regulating barrier function using mice lacking Gpr164 gene (Gpr164-/-). A loss-of-function mutation promoted cell proliferation disrupted Caco-2 line mice....
Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of on interaction between mother embryo is unclear. Here, we demonstrate that relationship maternal membrane receptor epsilon (mPRε) adipose tissue regulates embryonic nutritional environment growth after birth mice. The activation mPRε by increased during pregnancy enhances insulin resistance via prostaglandin production, efficiently providing glucose to...
The methyl cycle is a universal metabolic pathway providing groups for the methylation of nuclei acids and proteins, regulating all aspects cellular physiology. We have previously shown that inhibition in mammals strongly affects circadian rhythms. Since clocks evolved early during evolution operate organisms across tree life, we sought to determine whether link between two also conserved. Here, show biological rhythms species ranging from unicellular algae humans, separated by more than 1...
Indigestible polysaccharides, such as dietary fibers, benefit the host by improving intestinal environment. Short-chain fatty acids (SCFAs) produced gut microbial fermentation from fibers exert various physiological effects. The bacterial polysaccharide curdlan benefits environment, although its effect on energy metabolism and SCFA production remains unclear. Hence, this study aimed to elucidate of intake profiles, production, in a high-fat diet (HFD)-induced obese mouse model. Gut...
Scope Obesity and metabolic diseases are closely associated, individuals who become obese also prone to type 2 diabetes cardiovascular disorders. Gut microbiota is mediated by diet can influence host metabolism the incidence of Recent studies have suggested that improving gut through a fructooligosaccharide (FOS)‐supplemented may ameliorate obesity other Although accumulating evidence supports notion developmental origins health disease, underlying mechanisms remain obscure. Methods results...
Abstract Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of on interaction between mother embryo is unclear. Here, we demonstrate that relationship maternal membrane receptor epsilon (mPRε) adipose tissue regulates embryonic nutritional environment growth after birth mice. The activation mPRε by increased during pregnancy enhanced insulin resistance through production prostaglandins, thereby efficiently...
Abstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS)-short-chain fatty acid (SCFA)-carbohydrate metabolic axis. Healthy human donor-derived produced high EPS levels but...
<title>Abstract</title> Obesity is a major healthcare problem worldwide and induced by excess energy intake, resulting in gut microbial composition diversity changes. Through fermentation of dietary fibers, short-chain fatty acids (SCFAs) act as host sources signaling molecules via G protein-coupled receptors such GPR41. Acidipropionibacterium acidipropionici widely used many applications; however, vivo studies on the effect A. propionate production regulation homeostasis are unclear....
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract The global dietary supplement market is valued at around USD 100 billion. S -adenosylmethionine available as a to improve joints and “emotional well-being” in the US since 1999, has been prescription drug Europe treat depression arthritis 1975, but recent studies questioned its efficacy. In our body, critical for methylation of nucleic acids, histones many other targets. It believed that more better it would stimulate methylations health. organisms, methyl metabolism biological...