A5039014202- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Infectious Diseases and Mycology
- Sleep and related disorders
- Multiple Myeloma Research and Treatments
- Antifungal resistance and susceptibility
- Peptidase Inhibition and Analysis
- Infectious Diseases and Tuberculosis
- Bacteriophages and microbial interactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- COVID-19 impact on air quality
- Liver physiology and pathology
- Monoclonal and Polyclonal Antibodies Research
- Climate Change and Health Impacts
- Diagnosis and treatment of tuberculosis
- Sleep and Wakefulness Research
- Quinazolinone synthesis and applications
- Fungal Infections and Studies
- Amoebic Infections and Treatments
- Luminescence and Fluorescent Materials
- Thermoregulation and physiological responses
- Diagnosis and Treatment of Venous Diseases
Preferred Networks (Japan)
2022-2023
Japan Anti Tuberculosis Association
2009-2022
Fukujuji Hospital
2011-2022
Stanford University
2021-2022
University of Pennsylvania Health System
2018
Massachusetts General Hospital
2011-2013
Harvard University
2013
The University of Tokyo
2011
National Institute of Advanced Industrial Science and Technology
2004
Photosensitive dyes or photo sensitizers (PS) in combination with visible light and oxygen produce reactive species that kill cells the process known as photodynamic therapy (PDT). Antimicrobial PDT employs PS is selective for microbial a new treatment infections. Most antimicrobial based on tetrapyrrole phenothiazinium structures have been synthesized to carry quaternary cationic charges basic amino groups. However we recently showed cationic-substituted fullerene derivative were highly...
We evaluated a new line probe assay (LiPA) kit to identify Mycobacterium species and detect mutations related drug resistance in tuberculosis. A total of 554 clinical isolates tuberculosis (n = 316), avium 71), intracellulare 51), kansasii 54), other 62) were tested with the LiPA six hospitals. The was also used directly test 163 sputum specimens. results identification almost identical those conventional methods. Compared standard susceptibility testing for isolates, showed sensitivity...
Elevated matricellular proteins (MCPs), including osteopontin (OPN) and galectin-9 (Gal-9), were observed in the plasma of patients with Manila-type tuberculosis (TB) previously. Here, we quantified OPN, Gal-9, soluble CD44 (sCD44) by enzyme-linked immunosorbent assay (ELISA), another 29 cytokines Luminex 36 pulmonary TB, six subjects latent (LTBI), 19 healthy controls (HCs) from Japan for a better understanding roles MCPs TB. All TB showed positive results immunospot assays (ELISPOTs)....
Abstract The emergence and spread of multidrug-resistant (MDR) extensively drug-resistant (XDR) tuberculosis (TB) has raised public health concern about global control TB. To estimate the transmission dynamics MDR XDR TB, we conducted a DNA fingerprinting analysis 55 MDR/XDR Mycobacterium strains isolated from TB patients throughout Japan in 2002. Twenty-one (38%) were classified into 9 clusters with geographic links, which suggests that community is ongoing. Furthermore, M. more likely than...
Opportunistic fungal pathogens may cause an array of superficial infections or serious invasive infections, especially in immunocompromised patients. Cryptococcus neoformans is a pathogen causing cryptococcosis HIV/AIDS patients, but treatment limited due to the relative lack potent antifungal agents. Photodynamic inactivation (PDI) uses combination non-toxic dyes called photosensitizers and harmless visible light, which produces singlet oxygen other reactive species that produce cell death....
Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges for patients with hematological cancers. Here, we reveal distinctive requirements neutralizing TNF receptor ligands APRIL BAFF their activity in MM DLBCL, impacting protein translation production cells modulating the efficiency of ATM interactor (ATMIN/ACSIZ). Therapeutically, investigated use BCMA decoy (sBCMA-Fc) as an inhibitor BAFF. While wild-type sBCMA-Fc effectively blocked signaling MM, it...
To promote research on Mycobacterium avium complex (MAC) pathogenicity, animal models reflecting human progressive MAC lung disease (MAC-LD) are needed. Because there is high genetic and virulence diversity among clinical strains, choosing a suitable strain an important process for developing mouse model.
The assessment of airborne viruses in air is a critical step the design appropriate prevention and control measures. Hence, herein, we developed novel wet-type electrostatic sampler using viral dissolution buffer containing radical scavenging agent, verified concentration severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA hospital rooms inhabiting disease 2019 (COVID-19) patients public areas. damage caused by corona discharge was negligible when Buffer AVL used as collecting...
The Beijing genotype Mycobacterium tuberculosis (MTB), notorious for its virulence and predisposition to relapse, could be identified by spoligotyping based on genetic heterogeneity. plasma samples from 20 cases of 16 non-Beijing MTB infected individuals 24 healthy controls (HCs) were collected, antibodies against 11 antigens (Rv0679c142Asn, Rv0679c142Lys, Ag85B, Ag85A, ARC, TDM-M, TDM-K, HBHA, MDP-1, LAM, TBGL) measured ELISA. Compared the HCs, subjects showed higher titers anti-Ag85B IgG...
Abstract A prototype virus sampler using electrostatic precipitation has been developed to investigate aerosol infection by SARS-CoV-2. The consists of a discharge electrode placed inside vial, and thin layer viral lysis buffer at the bottom, working as collection electrode. was operated with sampling air flow rate 40 L/min. Collection efficiency is about 80% for 25nm 5.0µm diameter particles. We sampled food court commercial facility, connecting corridor clouded train station, two office...
Abstract Background Monitoring of airborne viruses in the air is a crucial step design appropriate prevention and control measures. We used novel wet-type electrostatic precipitator sampler using viral dissolution buffer containing radical scavenging agent to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA hospital room disease-2019 (COVID-19) patients public areas. Methods The concentration SARS-CoV-2 rooms total 10 consented hospitalized for COVID-19 was measured an...
In this paper, we present a robotic device for mouse tail vein injection. We propose holding mechanism to realize injection without anesthetizing the mouse, which consists of tourniquet, vacuum port, and adaptive tail-end fixture. The position target in 3D space is reconstructed from high-resolution stereo vision. detected by simple but robust line detector. Thanks proposed two-staged calibration process, total time process limited 1.5 minutes, despite that needle varies each trial....