A5072085018- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 and healthcare impacts
- Escherichia coli research studies
- Vibrio bacteria research studies
- Bacterial Infections and Vaccines
- Salmonella and Campylobacter epidemiology
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Respiratory viral infections research
- Single-cell and spatial transcriptomics
- Infection Control and Ventilation
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Listeria monocytogenes in Food Safety
- Diabetes and associated disorders
Tohoku University
2017-2025
Tohoku University Hospital
2022-2024
Hiroshima University
2023
National Institute of Infectious Diseases
2020
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2014-2016
Japan Pediatric Society
2014
Background: Bloodstream infections (BSIs), including persistent bacteremia (PB), are a leading source of morbidity and mortality globally. PB has higher rate than non- PB, but the clinical aspects in terms causative pathogens presence clearance not well elucidated. Therefore, this study aimed to describe epidemiological characteristics real-world setting. Methods: We performed retrospective observational survey patients who underwent blood culture between January 2012 December 2021 at Tohoku...
We assessed vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age 22 hospitals Japan during the 2013–14 season. Our study was conducted according a test-negative case-control design based on rapid diagnostic test (IRDT) results. Outpatients who came our clinics with fever 38°C or over and had undergone an IRDT were enrolled this study. Patients positive results recorded as cases, patients negative controls. Between...
Wastewater can be useful in monitoring the spread of antimicrobial resistance (AMR) within a hospital. The abundance antibiotic genes (ARGs) hospital effluent was assessed using metagenomic sequencing (mDNA-seq) and hybrid capture (xHYB). mDNA-seq analysis subsequent xHYB targeted enrichment were conducted on two samples per month from November 2018 to May 2021. Reads kilobase million (RPKM) values calculated for all 1,272 ARGs constructed database. monthly numbers patients with presumed...
The 2014/15 influenza season in Japan was characterised by predominant A(H3N2) activity; 99% of A viruses detected were A(H3N2). Subclade 3C.2a the major epidemic viruses, and genetically distinct from A/New York/39/2012(H3N2) vaccine strain Japan, which classified as clade 3C.1. We assessed effectiveness (VE) inactivated (IIV) children aged 6 months to 15 years test-negative case-control design based on rapid diagnostic test. Between November 2014 March 2015, a total 3,752 enrolled: 1,633...
There is increasing attention toward factors that potentially contribute to antibiotic resistance (AR), as well an interest in exploring the emergence and occurrence of bacteria (ARB). We monitored six ARBs cause hospital outbreaks wastewater influent highlight presence these general population. analyzed samples from a municipal treatment plant (MWWTP) (HW) for species ARB: Carbapenem-resistant Enterobacteria (CARBA), extended-spectrum β-lactamase producing (ESBL), multidrug-resistant...
Rational Corticosteroid therapy plays a key role in the treatment of COVID-19 patients with respiratory failure. However, rebound phenomenon after steroid cessation rarely occurs. Here, we investigated clinical features therapy. Methods In total, 84 treated corticosteroids were enrolled and analysed retrospectively. A was defined as when patient’s status deteriorated corticosteroid therapy, without secondary bacterial infection. Results Subjects group more likely to having severe failure...
Shiga toxin-producing Escherichia coli (STEC) can cause severe gastrointestinal disease and colonization among food handlers. In Japan, STEC infection is a notifiable disease, handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of not entirely known. We investigated genomic characteristics from patients asymptomatic in Miyagi Prefecture, Japan. Whole-genome sequencing (WGS) was performed on 65 isolates obtained 38 27 by public health...
We report a severe case of Chromobacterium haemolyticum pneumonia associated with near-drowning and detail the investigation pathogen river water. Our genomic environmental demonstrated that water in temperate region can be source C. causing human infections.
Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) because limited effective therapies. During infection, accumulation and activation macrophages monocytes lungs induce inflammatory mediators contribute to tissue injury, ARDS. However, therapeutic strategies that directly target activated macrophage have not been reported. Combination treatment etoposide (a cytotoxic agent) a corticosteroid has widely...
TAFRO syndrome, a subtype of idiopathic multicentric Castleman disease, is an acute or subacute systemic inflammatory disease that causes fever, generalized oedema (pleural effusion ascites), and thrombocytopenia associated with renal impairment, anaemia, organomegaly (hepatosplenomegaly lymph node enlargement). Coronavirus 2019 (COVID-19)-associated hyperinflammation caused by dysregulation proinflammatory cytokines. Cytokine storm syndrome common to both COVID-19 syndrome.Case report.A...
The purpose of this study was to characterize the strains extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) isolated from municipal and hospital wastewater by detecting antibiotic resistance genes (ARGs) as well susceptibility. To identify source ESBL-EC, multi-locus sequence typing plasmids that may carry ESBL-producing were conducted.Wastewater sampled twice a month February 2019 2020 treatment plant located in city northeastern Japan. Throughout period, 279 37...
The assessment of airborne viruses in air is a critical step the design appropriate prevention and control measures. Hence, herein, we developed novel wet-type electrostatic sampler using viral dissolution buffer containing radical scavenging agent, verified concentration severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA hospital rooms inhabiting disease 2019 (COVID-19) patients public areas. damage caused by corona discharge was negligible when Buffer AVL used as collecting...
A large number of microbes are not able to form colonies using agar-plating methods, which is one the reasons that cultivation based on solid media leaves majority microbial diversity in environment inaccessible. We developed a new Non-Colony-Forming Liquid Cultivation method (NCFLC) can selectively isolate non-colony-forming exclusively grow liquid culture. The NCFLC involves physically separating cells dilution-to-extinction (DTE) and then selecting those could medium. was applied marine...
Introduction. This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable Haemophilus influenzae infection. In Japan, BLNAR H. widespread and has become a clinical concern, especially in paediatrics otolaryngology, but not been previously recognized as causative agent obstetric or gynaecological Case presentation. A 31-year-old pregnant woman presented at 17 weeks 6 days gestation with high fever; she was admitted diagnosis...
Abstract Background The mortality rates of coronavirus disease 2019 (COVID-19) have been changed across the epidemiological waves. aim was to investigate differences in COVID-19 patients Japan 6 waves stratified by age group and Coronavirus Clinical Characterisation Consortium (4C) score risk group. Methods A total 56 986 Registry from 2 March 2020 1 February 2022 were enrolled. These categorized into 4 groups based on their 4C score. Mortality each calculated separately for different...
Bacillus cereus commonly causes catheter-related bloodstream infections (BSIs) in hospital settings, and occasionally occurs fatal central nervous system (CNS) complications. B. harboring Ba813, a specific chromosomal marker of anthracis, has been found patients with severe infection nosocomial BSI. However, the bacteriological profile clinical feature Ba813 (+) are unclear. Fifty-three BSI were examined. Isolates evaluated for anthracis-related food poisoning-related virulence, multilocus...
Dear Editor:Emergency response in a natural disaster causing evacuation, transportation, and mass gathering the affected areas may contrast prevention strategies COVID-19 pandemic, includ...
Patients with severe Coronavirus disease 2019 (COVID-19) are at high risk for secondary infection multidrug-resistant organisms (MDROs). Secondary infections contribute to a more clinical course and longer intensive care unit (ICU) stays in patients COVID-19. A man his 60s was admitted the ICU university hospital COVID-19 pneumonia requiring mechanical ventilation. His respiratory condition worsened further due persistent bacteremia caused by imipenem-non-susceptible Klebsiella aerogenes he...