A5085571213- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Optical Imaging and Spectroscopy Techniques
- Abdominal vascular conditions and treatments
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Hemodynamic Monitoring and Therapy
- Non-Invasive Vital Sign Monitoring
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Abdominal Surgery and Complications
- Colorectal Cancer Treatments and Studies
- Abdominal Trauma and Injuries
- T-cell and B-cell Immunology
- Urological Disorders and Treatments
- Metastasis and carcinoma case studies
- Metabolomics and Mass Spectrometry Studies
- Traumatic Ocular and Foreign Body Injuries
- Intestinal and Peritoneal Adhesions
- MicroRNA in disease regulation
- Multiple and Secondary Primary Cancers
- Long-Term Effects of COVID-19
- Appendicitis Diagnosis and Management
- Pneumonia and Respiratory Infections
Osaka University
2019-2024
Kansai Medical University
2016-2021
Osaka University Hospital
2021
Osaka Gakuin University
2019
Osaka Rosai Hospital
2016-2017
Since its discovery over three decades ago, signal transducer and activator of transcription 1 (STAT1) has been extensively studied as a central mediator for interferons (IFNs) signaling antiviral defense. Here, using genetic biochemical assays, we unveil Thr 748 conserved IFN-independent phosphorylation switch in Stat1, which restricts IFN promotes innate inflammatory responses following the recognition bacterial-derived toxin lipopolysaccharide (LPS). Genetically engineered mice expressing...
Resting memory B cells can be divided into classical or atypical groups, but the heterogenous marker expression on activated makes similar classification difficult. Here, by longitudinal analysis of mass cytometry and CITE-seq data from cohorts with COVID-19, bacterial sepsis, BNT162b2 mRNA vaccine, we observe that resting cell consist CD45RB+ CD45RBlo memory, which latter contains two distinct groups CD11c+ CD23+ non-classical cells. CD45RB levels remain stable in these after activation,...
The purpose of this study was to determine the prognostic factors non-occlusive mesenteric ischemia (NOMI) and examine treatment strategies that could improve its prognosis.We retrospectively identified 30 patients who underwent emergency laparotomy for NOMI in Kansai Medical University Hospital (Hirakata, Japan) from April 2013 December 2017. We examined related discharge outcome also impact open abdominal management second look operation strategy (OSS) by dividing into non-OSS group OSS...
Aims An angiographic examination is necessary for the diagnosis of takotsubo cardiomyopathy ( TTC ). However, in intensive care unit ICU ), intensivists often see patients whom cannot be diagnosed because they undertake angiography due to patient's poor general condition. We defined such cases as clinical cTTC ) and investigated incidence background at Kansai Medical University Hospital (Osaka, Japan). Methods The study involved 5,084 who were admitted between January 2013 December 2017....
Sepsis causes a systemic inflammatory reaction by destroying intestinal flora, which leads to poor prognosis. In this study, we sought clarify the characteristics of fecal flora and metabolites in mouse model sepsis comprehensive metagenomic metabolomic analysis.We performed cecal ligation puncture procedure create mild model. We collected samples on day 0 (healthy condition) days 1 7 after determine microbiome metabolites. analyzed using 16S rRNA gene sequencing capillary electrophoresis...
We divided patients treated with emergency surgery for pan-peritonitis caused by colon perforation into the survival group and death based on outcome at postoperative day 30 examined prognostic factors perforation.The in 76 consecutive who underwent Kansai Medical University Hospital (Hirakata, Japan) from April 2011 to March 2017 were investigated 30.The average age of (41 men/35 women) was 73 years, causative disease malignant/benign 18/58 cases, ileocecal site 8 ascending 6, transverse 2,...
Historically, the presence of hepatic portal venous gas (HPVG) and pneumatosis intestinalis (PI) have been reported to be associated with bowel necrosis fatal outcome. However, there are no criteria judge whether has occurred. We aimed examine factors in patients HPVG PI.The study comprised 25 who were diagnosed as having and/or PI based on computed tomography (CT) findings Department Emergency Critical Care Medicine, Kansai Medical University Hospital (Osaka, Japan) between April 2013...
Background Superior mesenteric artery syndrome ( SMAS ) is often associated with gastric dilatation but, very rarely, it can be emphysema. In addition, there are few reported cases accompanied by septic shock. Case Presentation A 64‐year‐old man was transferred to our hospital vomiting and abdominal distention. He went into shock showed impaired consciousness. Blood biochemistry tests elevated levels of C‐reactive protein. An computed tomography scan revealed a dilated stomach proximal...
<title>Abstract</title> Resting memory B-cells can be divided into classical and non-classical groups based on differential expression of markers such as CD27 CD11c, while activated express a combination markers, making their ontogeny hard to determine. Here by longitudinal analysis COVID-19, bacterial sepsis, BNT162b2 mRNA vaccine recipients mass cytometry CITE-seq we describe three-branch structure resting B-cell consisting “classical” CD45RB<sup>+</sup> two branches CD45RB<sup>lo...
This study aimed to comprehensively compare host responses of patients with bacterial sepsis and those viral (COVID-19) by analyzing messenger RNA (mRNA) microRNA (miRNA) profiles shed light on their distinct pathophysiological mechanisms.
Case A 40‐year‐old man received fist blows to his chest and abdomen. He presented with external jugular vein distention facial congestion. Chest X‐ray showed bilateral pulmonary Levine V / VI holosystolic murmur was audible. Echocardiography left‐to‐right shunt flow across the perimembranous region of ventricular septum. The diameter hole approximately 13 mm. We diagnosed septal perforation, started an infusion, administered vasopressors. However, circulatory dynamics could not be...
Abstract Purpose Urinary extravasation is one of the major complications after non-operative management traumatic renal injury and may lead to urinary tract infection sepsis. The purpose this study was evaluate these factors in patients with injury. Methods This a multi-center, retrospective, observational performed at three tertiary referral hospitals Osaka prefecture. We included transported centers between January 2008 December 2018. excluded who either died or underwent nephrectomy...
Purpose: Current guidelines recommend rhythm checks every 2 minutes during CPR, but evidence for this recommendation is insufficient. Recent reports identified regional cerebral oxygen saturation (rSO ) monitoring as useful in detecting ROSC and that coronary perfusion decrease with the 2-minute check. On basis of our previous study, we began TripleCPR 16 which omits because stopping chest compression to check may increase damage ROSC. Methods: The multicenter, prospective study January...
To evaluate the relationship between procalcitonin value in blood on hospital admission and its subsequent change prognosis among sepsis patients.A single-center, retrospective, observational study.Critical care center Japan.Sepsis patients 18 years old or older admitted from January 1, 2015, to March 31, 2018.None.Among 173 enrolled, median age was 74 (interquartile range, 64-79 yr old), there were 102 men. The of 14.8 ng/mL 3.5-78.4 ng/mL), serum next day 0 -4.5 5.2 ng/mL). Mortality at 28...
Abstract The regional oxygen saturation (rSO₂) values of brain and muscle tissues can be measured simultaneously even if blood pressure cannot due to circulatory failure associated with shock may continuously reflect the supply‐demand balance.
Abstract Background: Community-acquired pneumonia (CAP) is defined as an acute lung infection involving the alveoli that occurs in a patient without recent health care exposure. A complication of CAP severe sepsis, syndrome often accompanied by systemic inflammation and organ dysfunction. The aim this study was to evaluate mRNA miRNA whole blood perform integrative analysis assess cellular signals play role pathogenesis patients with CAP-associated sepsis. Methods: This prospective,...
Abstract OBJECTIVES : This study aimed to comprehensively compare host responses sepsis and COVID-19 by analyzing messenger RNA (mRNA) microRNA (miRNA) profiles shed light on their distinct pathophysiological mechanisms. DESIGN Prospective observational SETTING Whole blood sequencing was used analyze mRNA miRNA of patients diagnosed as having or at the Department Trauma Emergency Medicine, Osaka University Graduate School Medicine. PATIENTS Twenty-two patients, 35 15 healthy subjects...
Introduction: The simplified monitoring of regional cerebral oxygen saturation (rSO 2 ) is a non-invasive method measuring perfusion, but continuous changes in the rSO values among OHCA patients pre-hospital settings have not been sufficiently investigated. Our objective to investigate association between change pattern and patient outcome. Methods: We recently developed very small portable system that can be used setting. monitor immediately after attachment; performed continuously during...
Introduction: There are some critical ill patients who cannot measure oxygen saturation (SpO 2 ) by pulse oximeter at the pre-hospital settings. For example, among emergency were treated medical service (EMS) personnel of Osaka Municipal Fire Department in 2016, there 3,571 had urgent conditions judged on-scene EMS but did not have cardiopulmonary arrest (CPA), measurement SpO scene could be measured for 395 patients. On other hand, cerebral regional (rSO during resuscitation has been...