A5045957610- Hearing, Cochlea, Tinnitus, Genetics
- Intracranial Aneurysms: Treatment and Complications
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Inflammatory mediators and NSAID effects
- Neurological Complications and Syndromes
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Allergic Rhinitis and Sensitization
- Bone Metabolism and Diseases
- Maternal and fetal healthcare
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive tract infections research
- Connexins and lens biology
- Bone health and treatments
- Neuropeptides and Animal Physiology
- Vitamin K Research Studies
- Nitric Oxide and Endothelin Effects
- Ear Surgery and Otitis Media
- Clinical Nutrition and Gastroenterology
National Hospital Organization
2024
Tochigi Medical Center
2024
Northwestern University
2019-2024
Osaka University
2023
Keio University
2015-2021
Hokkaido University
2012-2019
Midwestern University
2019
Hokkaido University Hospital
2016-2017
National Cancer Center Hospital East
2016
Nihon University
2004-2009
Structured Abstract Authors – Nishijima Y, Yamaguchi M, Kojima T, Aihara N, Nakajima R, Kasai K Objective To determine the levels of receptor activator NFkB ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) during orthodontic tooth movement. A second objective was to investigate effect compression force on RANKL OPG production from human periodontal ligament (hPDL) cells. Design Ten adolescent patients were included. GCF collected at distal cervical margins...
The ligand receptor activator of NFκB (RANKL) plays an important role in osteoclast formation. However, very little is known about the relationship between external apical root resorption during orthodontic treatment and RANKL. We hypothesized that compressive force responsible for RANKL formation up-regulation osteoclastogenesis periodontal ligament (PDL) cells from patients with severe orthodontically induced resorption. osteoprotegerin (OPG) production, TRAP-positive cells, resorptive...
Prestin (SLC26A5)-mediated voltage-driven elongations and contractions of sensory outer hair cells within the organ Corti are essential for mammalian cochlear amplification. However, whether this electromotile activity directly contributes on a cycle-by-cycle basis is currently controversial. By restoring motor kinetics in mouse model expressing slowed prestin missense variant, study provides experimental evidence acknowledging importance fast action to Our results also demonstrate that...
The effects of hemoglobin and cerebrospinal fluid from patients with subarachnoid hemorrhage (CSF-SAH) on endothelium-dependent relaxation were studied. At 10(-6) M, somewhat inhibited the induced by A23187 in rings canine basilar artery. 3 X it almost completely same response. did not significantly inhibit smooth muscle mechanisms as papaverine-induced was hemoglobin. It also demonstrated that pretreatment arterial CSF-SAH resulted a dose-dependent inhibition A23187. inhibitory effect...
Mechanical stress by an orthodontic appliance induces biologically active substances. Fibroblast growth factor is a multifunctional cytokine that has various effects on fibroblast cells, and factor-2 plays important role in remodeling of the periodontal ligament. The receptor activator nuclear kappa B ligand (RANKL) protein involved osteoclastogenesis we recently reported RANKL levels were increased compression force vitro. In present study, investigated production human ligament...
ABSTRACT We studied injury of Escherichia coli O157:H7 cells in 11 food items during freeze storage and methods isolating freeze-injured E. from foods. Food samples inoculated with were stored for 16 weeks at −20°C a freezer. Noninjured injured counted by using tryptic soy agar sorbitol MacConkey supplemented cefixime potassium tellurite. Large populations salted cabbage, grated radish, seaweed, tomato samples. In an experiment to detect artificially contaminated cells, the organism was...
Thanks to the advent of rapid DNA sequencing technology and its prevalence, many disease-associated genetic variants are rapidly identified in genes from patient samples. However, subsequent effort experimentally validate define their pathological roles is extremely slow. Consequently, pathogenicity most solely speculated silico, which no longer deemed compelling. We developed an experimental approach efficiently quantify pathogenic effects with a focus on SLC26A4, essential for normal inner...
To determine the concentration of vitamin K including K1 (phylloquinone) and K2 (menaquinone-n; MK-n) in maternal milk Japanese women.We collected human samples from more than 4000 mothers living throughout Japan December 1998 to September 1999, analysed contents 834 samples. We defined as group A 555 among them that met following conditions: breast who were under 40 y old, not habit smoking and/or using supplements, whose babies showed no symptoms atopy birthweights 2.5 kg or more. Vitamins...
Vascular responses to acetylcholine (ACh) and the calcium ionophore A23187 were studied in rings of canine basilar arteries. In preparations that precontracted a stable plateau by 3 X 10(-6) M prostaglandin F2 alpha (PGF2 alpha), 10(-9) 10(-7) elicited significant relaxation arteries if endothelium was intact. Judging from histologic findings, ability ring relax this manner is due presence endothelium. The same concentration did not vascular tissues which purposely disrupted. Although 10(-3)...
Relapse of teeth that have moved during orthodontic treatment is a major clinical issue with respect to the goals successful treatment. Such relapse physiologic response supporting tissues application force, and mainly attributed occlusal instability increased mechanical tension exerted by periodontal ligament (PDL). Relaxin, member insulin/relaxin family structurally related hormones, has an influence on many processes, such as collagen turnover, angiogenesis, antifibrosis. Therefore,...
Objective: Quality of life (QoL) and subjective symptoms are predominantly used to evaluate treatment outcome patients with vestibular schwannoma (VS). However, for undergoing conservative treatment—the most frequently intervention—the association between QoL is unclear. Moreover, it unknown whether VS-related tinnitus could be associated the audiological psychological status patient. Our overall aim provide objective evidence this better guide VS. Methods: In a prospective study, we...
Background The Tinnitus Sample Case History Questionnaire was determined as a standardized questionnaire for obtaining patient case histories and characterizing patients into subgroups at the Research Initiative in 2006. In this study, we developed Japanese version of evaluating clinical characteristics with tinnitus. will be available treatments tinnitus comparing data on research centers. Aims/Objectives To evaluate Japan using newly Questionnaire. Study design This prospective study based...
Objectives In the management of vestibular schwannoma (VS), patient‐perceived outcomes should be given as much attention physician‐reported objective outcomes. Concomitant symptoms can annoying for sufferers, lowering quality life (QoL). However, it is difficult to determine degree which these lower QoL using only measures. The Penn Acoustic Neuroma Quality Life Scale (PANQOL) a validated disease‐specific questionnaire commonly used assess in VS patients. It was developed and published...
Abstract Aim: To assess the usefulness of a new method for cesarean section (CS) that is comprised transverse incision into uterine fundus, developed women with placentas covering entire anterior wall, and introduced in September 2006. Material Methods: Review medical records 12 29 who underwent CS by conventional methods, respectively, placenta previa, accreta (accreta, increta percreta) or widely wall which cannot be excluded, between June 2003 March 2011. Results: Placenta (67% [8/12] vs...
ABSTRACT Pendrin and prestin are evolutionary conserved membrane proteins that essential for normal hearing. is an anion transporter required development maintenance of ion homeostasis in the inner ear, while a voltage-dependent motor responsible cochlear amplification high sensitivity frequency selectivity mammalian Dysfunction these result hearing loss humans, numerous deafness-associated pendrin variants have been identified patients. However, pathogenic impacts many ambiguous. Here we...