A5077871111- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Reproductive Biology and Fertility
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Salivary Gland Disorders and Functions
- Thermal Regulation in Medicine
- Anesthesia and Neurotoxicity Research
- Sperm and Testicular Function
- Oral Health Pathology and Treatment
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Salivary Gland Tumors Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Nerve Injury and Rehabilitation
- Alzheimer's disease research and treatments
- Pleural and Pulmonary Diseases
- Vitamin C and Antioxidants Research
- Fungal Infections and Studies
Showa Pharmaceutical University
2015-2025
Showa University
2022-2023
Osaka University
2021
The University of Tokyo
2020
Tsurumi University
2007-2018
Saiseikai Matsuyama Hospital
2017
Tokyo Institute of Technology
1994-2016
Baba Memorial Hospital
2014
Shinshu University
2014
Kanazawa University
2004-2013
There is growing international interest in identifying the effects of ageing on oral health and appropriate strategies for managing disorders. The Japanese Society Gerodontology (JSG), as official representative researchers clinicians interested geriatric dentistry Japan, makes several recommendations concept "oral hypofunction."This study proposes diagnostic criteria management to reduce risk hypofunction among older people.We define a presentation 7 signs or symptoms: uncleanness; dryness;...
The aim of this study was to document the effects a new sedative agent, dexmedetomidine, on mortality rate and inflammatory responses endotoxin-induced shock in rats.Randomized laboratory study.University experimental laboratory.Fifty-seven male rats.The animals were randomly assigned one four groups. endotoxemic group (n = 16) received intravenous Escherichia coli endotoxin (15 mg/kg over 2 mins). saline control 10) given alone. dexmedetomidine alone 15) treated identically but also...
We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. also ability to resuscitate rats after lethal doses these local anesthetics. Bupivacaine, or was infused at a rate 2 mg. kg(-1). min(-1) while electrocardiogram, electroencephalogram, arterial pressure were continuously monitored. When asystole recorded, drug infusion stopped resuscitation sequence begun. Epinephrine 0.01 mg/kg administered 1-min intervals external cardiac compressions...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates variety of biological effects by binding to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). Although numerous animal studies have demonstrated the harmful dioxins, it remains controversial whether dioxins pose risk human health. Enhanced lytic replication EBV for development autoimmune diseases and cancers. This study evaluated possibility AhR reactivates...
Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism oxaliplatin-induced hyperalgesia unknown. In present study, we investigated effects on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons rats.Behavioral assessment using acetone spray test showed that 3 and 6 mg/kg (i.p.) induced acute hypersensitivity after 1, 2, 4, 7 days. Real-time PCR (6 mg/kg) significantly increased TRPA1 mRNA expression DRGs at...
Purpose: The saturation of health foods in the market is coupled with inadequate information on their safe usage. Recently, issues caused by Foods Function Claims (FFCs) have resulted 81 suspected deaths Japan, where labelling precautions proved ineffective. We previously developed a Communication Index to assess usability and comprehension FFC from perspective healthcare professionals (HCPs). It important explore ways evaluate improve consumers' ensure Patients Methods: conducted user...
Background Cytokines and nitric oxide are believed to participate importantly in the pathogenesis of endotoxin-induced shock. Several investigators have documented that ketamine attenuates production cytokines endotoxemia, but little is known concerning hemodynamic effects drug this state. The objective current study was assess potential modifying endotoxemia. Methods authors randomly assigned 40 rats one four equal groups: endotoxin alone, receiving Escherichia coli (15 mg/kg, administered...
Objective To clarify the effects of posttreatment with propofol administration on mortality rate and cytokine responses to endotoxin-induced shock in rats. Design Randomized prospective laboratory study. Setting University laboratory. Subjects Thirty-three male Interventions Animals were randomly assigned one three groups (n = 11 per group): a) endotoxemic group, receiving intravenous Escherichia coli endotoxin (20 mg/kg over 2 mins); b) early treated identically group additional (10 bolus,...
Painful peripheral neuropathy is a common adverse effect of paclitaxel (PTX) treatment. To analyze the contribution transient receptor potential vanilloid 1 (TRPV1) in development PTX-induced mechanical allodynia/hyperalgesia and thermal hyperalgesia, TRPV1 expression rat spinal cord was analyzed after intraperitoneal administration 2 4 mg/kg PTX. PTX treatment increased protein cord. Immunohistochemistry showed that (4 mg/kg) superficial layers dorsal horn 14 days Behavioral assessment...
We examined the effect of dextran (molecular weight 71,000) in counteracting surfactant inhibitory action plasma albumin. The surface adsorption time 0.5 mg/ml modified natural (MNS; porcine lung extract consisting phospholipids and hydrophobic proteins) with 7.5 albumin decreased from 681 to 143 s by addition at a concentration 10 (P < 0.01). minimum tension 2.0 MNS 30 over 21 mN/m below 3 when was added Surfactant-deficient newborn rabbits given ml/kg liquid containing had mean tidal...
Objective: To evaluate the ability of Moisture Checker for Mucus (MCM), a device which measures weight percent water content in oral mucosal epithelium, diagnosis dry mouth. Method: Forty‐three consecutive patients seen at Dry Mouth Clinic Tsurumi University were divided into two groups by diagnostic criteria hyposalivation defined stimulated salivary flow rate ≤10 ml per 10 min. The MCM values buccal, tongue and labial mucosa each group compared. Results: value normal salivation was...
Robot-assisted laparoscopic radical prostatectomy (RALP) requires a steep Trendelenburg position and CO2 pneumoperitoneum for several hours to secure the surgical visual field. The present study was performed investigate influence of each angle during RALP on cardiovascular respiratory homeostasis.Forty-seven ASA physical status 1 2 patients underwent open retropubic (RRP) or RALP. Patients receiving were randomized undergo operation in 20°, 25° 30° position. Heart rate (HR), mean arterial...
We compared the effects of propofol and sevoflurane on bupivacaine-induced central nervous system cardiovascular toxicity in rats. Thirty-four male Sprague-Dawley rats were anesthetized with 70% N2 O/30% O2 plus 50% effective dose (ED50) (propofol group, n = 12); ED50 (sevoflurane 11); or (control 11). Bupivacaine was infused at a constant rate 2 mg [center dot] kg-1 min-1 while electrocardiogram, electroencephalogram, invasive arterial pressure continuously monitored. The cumulative doses...
The molar approach of laryngoscopy is reported to improve glottic view in sporadic cases difficult laryngoscopy. authors studied the effect approaches and optimal external laryngeal manipulation (OELM) using Macintosh blade.A series 1,015 adult patients who underwent general anesthesia tracheal intubation was studied. Laryngoscopy carried out a no. 3 or 4 standard blade. Three consecutive trials direct midline left- right-molar were under full muscle relaxation with head neck positioning....
The current study examined the ability of a new adsorbent, CTR, to remove enterotoxins, toxic shock syndrome toxin-1 (TSST-1), and cytokines from blood and/or serum in vitro effects extracorporeal treatment with CTR column on mortality rate inflammatory responses endotoxic vivo.Laboratory investigation.University company experimental laboratory.CTR is composed porous cellulose beads which hydrophobic organic compound hexadecyl alkyl chain has been covalently bound surface as ligand....
Oxaliplatin is a chemotherapeutic agent that effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia serious side effect oxaliplatin treatment. Although the therapeutic drug pregabalin beneficial for preventing peripheral neuropathic pain by targeting voltage-dependent calcium channel α2δ-1 (Cavα2δ-1) subunit, oxaliplatin-induced acute hypersensitivity uncertain. To analyze contribution Cavα2δ-1 subunit to development hypersensitivity, expression in rat...