A5091732770- Advanced Drug Delivery Systems
- Microbial Natural Products and Biosynthesis
- Drug Solubulity and Delivery Systems
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Marine Sponges and Natural Products
- Antimicrobial Peptides and Activities
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Plant chemical constituents analysis
- Medicinal Plant Pharmacodynamics Research
- Pickering emulsions and particle stabilization
- Crystallization and Solubility Studies
- Biochemical and Molecular Research
- Microencapsulation and Drying Processes
- bioluminescence and chemiluminescence research
- Advancements in Transdermal Drug Delivery
Ministry of Public Health
2019-2023
Department of Medical Sciences
2019-2023
Osaka University
2007-2015
Voriconazole (VCZ) is a broad-spectrum antifungal agent used to treat ocular fungal keratitis. However, VCZ has low aqueous solubility and chemical instability in solutions. This study aimed develop eye drop formulations using cyclodextrin (CD) water-soluble polymers, forming CD complex aggregates improve the stability of VCZ. The was greatly enhanced sulfobutyl ether β-cyclodextrin (SBEβCD). addition polyvinyl alcohol (PVA) showed synergistic effect on VCZ/SBEβCD solubilization...
In the course of our search for anti-dormant mycobacterial substances from marine organisms, we previously isolated three new aminolipopeptides, named trichoderins A, A1 and B, culture sponge-derived fungus Trichoderma sp. determined their chemical structures. To identify gene that could confer a resistance to trichoderin prepared transformants Mycobacterium (M.) smegmatis, which were transformed with genomic DNA library M. bovis BCG constructed in multi-copy shuttle cosmid pYUB145. Then,...
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