A5051820864- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Genomics, phytochemicals, and oxidative stress
- Asthma and respiratory diseases
- Vaccine Coverage and Hesitancy
- IL-33, ST2, and ILC Pathways
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Bacterial Infections and Vaccines
- Immune responses and vaccinations
- Celiac Disease Research and Management
- Phytoestrogen effects and research
- Long-Term Effects of COVID-19
- Hepatitis Viruses Studies and Epidemiology
- Pregnancy and Medication Impact
- Sulfur Compounds in Biology
- Biosimilars and Bioanalytical Methods
- Clostridium difficile and Clostridium perfringens research
- Spinal Hematomas and Complications
- Mast cells and histamine
- Viral Infections and Immunology Research
- Intracranial Aneurysms: Treatment and Complications
Murdoch Children's Research Institute
2019-2025
The University of Melbourne
2019-2025
Royal Children's Hospital
2022-2025
Monash University
2018-2022
Australian Regenerative Medicine Institute
2021
ORCID
2021
Baker Heart and Diabetes Institute
2014
The Alfred Hospital
2014
<h3>Importance</h3> The immune response in children with SARS-CoV-2 infection is not well understood. <h3>Objective</h3> To compare seroconversion nonhospitalized and adults mild identify factors that are associated seroconversion. <h3>Design, Setting, Participants</h3> This household cohort study of collected weekly nasopharyngeal throat swabs blood samples during the acute (median, 7 days for 12 [IQR, 4-13] days) convalescent 41 31-49] periods after polymerase chain reaction (PCR)...
Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote settings and children. We compared the measurement SARS-CoV-2 spike-specific IgG paired samples collected using standard venepuncture (serum) hemaPEN® microsampling DBS device from children adults. A total 83 participants (10 months 65 years age),...
Abstract Background To determine if dried blood spot specimens (DBS) can reliably detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, we compared the SARS-CoV-2 IgG antibody response in paired serum and eluates from DBS specimens. Methods A total of 95 samples were collected 74 participants (aged 1–63 years) as part a household cohort study Melbourne, Australia. antibodies specific for receptor-binding domain (RBD) S1 proteins between using an FDA-approved ELISA...
Abstract There is limited understanding of antibody responses in children across different SARS-CoV-2 variants. As part an ongoing household cohort study, we assessed the response among unvaccinated infected with Wuhan, Delta, or Omicron variants, as well vaccinated breakthrough infection, using a S1-specific IgG assay and surrogate virus neutralization test (% inhibition). Most Delta (100%, 35/35) (81.3%, 13/16) variants seroconverted by one month following infection. In contrast, 37.5%...
The dietary isothiocyanate L-sulforaphane (LSF), derived from cruciferous vegetables, is reported to have several beneficial biological properties, including anti-inflammatory and immunomodulatory effects. However, there limited data on how LSF modulates these effects in human immune cells. present study was designed investigate the of (10 µM 50 µM) peripheral blood mononuclear cell (PBMC) populations cytokine secretion healthy adult volunteers (n = 14), presence or absence bacterial...
Streptococcus pneumoniae (the pneumococcus) is a human pathogen of global importance, classified into serotypes based on the type capsular polysaccharide produced. Serotyping pneumococci essential for disease surveillance and vaccine impact measurement. However, accuracy serotyping methods can be affected by previously undiscovered variants. Previous studies have identified variants serotype 14, highly invasive included in all licensed formulations. potential these to influence evade...
The immune response in children elicited by SARS-CoV-2 Omicron infection alone or combination with COVID-19 vaccination (hybrid immunity) is poorly understood. We examined the humoral and cellular following unvaccinated who were previously vaccinated mRNA vaccine.
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little known about the immune implications hyposplenism in CD or optimal vaccination strategy. In this study, effects CD, accuracy screening approaches protective responses induced by two different vaccines were examined. Active treated cohorts, healthy surgically splenectomised controls underwent testing...
BackgroundCOVID-19 vaccine booster doses restore effectiveness lost from waning immunity and emerging variants. Fractional dosing may improve COVID-19 acceptability uptake will reduce the per-dose cost of programmes. We sought to quantify immunogenicity, reactogenicity, safety a half-dose BNT162b2 (Pfizer-BioNTech) relative standard formulation.MethodsThis randomised, controlled, non-inferiority trial recruited adults in Mongolia primed with two-dose homologous ChAdOx1 nCov-19...
Encapsulated bacteria such as
Abstract Importance The immune response in children with SARS-CoV-2 infection is not well understood. Objective To compare seroconversion and adults non-hospitalized (mild) to understand the factors that influence this. Design Participants were part of a household cohort study infection. Weekly nasopharyngeal/throat swabs blood samples collected during acute convalescent period following PCR diagnosis for analysis. Setting recruited at Royal Children’s Hospital, Melbourne, Australia between...
Abstract Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote settings and children. We compared the measurement SARS-CoV-2 spike-specific IgG paired samples collected by standard venepuncture (serum) hemaPEN® microsampling DBS device from children adults using an established in-house ELISA. A total 83...
Abstract The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established for investigating pre-clinical therapies diseases, such as asthma. Here, we examined the effects of several experimental compounds with potential anti-asthmatic including resveratrol (RV), relaxin (RLN), l -sulforaphane (LSF), valproic acid (VPA), and trichostatin A (TSA) using both prevention reversal disease. We undertook novel analytical approach focal plane array (FPA) synchrotron...
BackgroundRecurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether bacille Calmette-Guérin (BCG) vaccine can attenuate sore recurrences through off-target immunomodulatory effects.MethodsIn this nested randomised controlled trial within multicentre, phase 3 BRACE trial, 6828 healthcare workers were 36 sites Australia, Netherlands, Spain, United Kingdom and Brazil, receive BCG-Denmark no BCG (1:1 ratio...