A5072111063- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Immune responses and vaccinations
- Cellular transport and secretion
- Vaccine Coverage and Hesitancy
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Cytomegalovirus and herpesvirus research
Friedrich Schiller University Jena
2009-2021
Royal Children's Hospital
2021
Yale University
2009-2011
The inositol 1,4,5-trisphosphate receptor (InsP(3)R), an intracellular calcium channel, has three isoforms with >65% sequence homology, yet the differ in their function and regulation by post-translational modifications. We showed previously that InsP(3)R-1 is functionally modified O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) (Rengifo, J., Gibson, C. Winkler, E., Collin, T., Ehrlich, B. E. (2007) J. Neurosci. 27, 13813-13821). now report effect of O-GlcNAcylation on...
Background: Postnatal infection with cytomegalovirus (CMV) in very-preterm and very-low-birth-weight infants, transmitted through breast milk (BM), is potentially associated adverse outcomes. This study aimed to investigate the incidence clinical significance of postnatal CMV a tertiary neonatal intensive care unit. Methods: Infants CMV-seropositive mothers born unit Melbourne, Australia, were observed for 14 weeks from birth prospective cohort study. Maternal BM infant urine tested weekly...
BackgroundRecurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether bacille Calmette-Guérin (BCG) vaccine can attenuate sore recurrences through off-target immunomodulatory effects.MethodsIn this nested randomised controlled trial within multicentre, phase 3 BRACE trial, 6828 healthcare workers were 36 sites Australia, Netherlands, Spain, United Kingdom and Brazil, receive BCG-Denmark no BCG (1:1 ratio...