A5103128599- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- COVID-19 Impact on Reproduction
- Immune responses and vaccinations
- Emergency and Acute Care Studies
- Pediatric health and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Pleural and Pulmonary Diseases
Murdoch Children's Research Institute
2022-2024
Peter Doherty Institute
2024
The University of Melbourne
2024
Royal Children's Hospital
2022-2024
Nonpharmaceutical interventions (NPIs) implemented to contain SARS-CoV-2 have decreased invasive pneumococcal disease. Previous studies proposed the decline is due reduced transmission or suppression of respiratory viruses, but mechanism remains unclear. We undertook a secondary analysis data collected from clinical trial evaluate impact NPIs on carriage and density, drivers disease, during COVID-19 pandemic in Ho Chi Minh City, Vietnam. Nasopharyngeal samples children aged 24 months were...
Streptococcus pneumoniae (the pneumococcus) is a human pathogen of global importance, classified into serotypes based on the type capsular polysaccharide produced. Serotyping pneumococci essential for disease surveillance and vaccine impact measurement. However, accuracy serotyping methods can be affected by previously undiscovered variants. Previous studies have identified variants serotype 14, highly invasive included in all licensed formulations. potential these to influence evade...
Limited data from Asia are available on long-term effects of pneumococcal conjugate vaccine introduction carriage. Here we assess the impact 13-valent (PCV13) nasopharyngeal carriage prevalence, density and antimicrobial resistance. Cross-sectional surveys were conducted pre-PCV13 (2015) post-PCV13 (2017 2022). Pneumococci detected quantified by real-time PCR swabs. DNA microarray was used for molecular serotyping to infer genetic lineage (Global Pneumococcal Sequence Cluster). The study...
Pleural empyema is a serious complication of pneumonia in children. Negative bacterial cultures commonly impede optimal antibiotic therapy. To improve identification, we developed molecular assay and evaluated its performance compared with culture. Our multiplex-quantitative PCR to detect Streptococcus pneumoniae , pyogenes Staphylococcus aureus Haemophilus influenzae was assessed using genomic DNA laboratory-prepared samples (n = 267). evaluate clinical performance, conducted the Molecular...
Background: Data on pneumococcal serotype changes in hospitalised children following conjugate vaccine (PCV) introduction low-middle income countries are limited. Mongolia introduced the 13-valent PCV (PCV13) into national immunisation programme from 2016. We measured effect of PCV13 nasopharyngeal carriage with pneumonia over a six-year period.Methods: Children aged 2-59 months (n=17,607) were enrolled during April 2015 to June 2021 four districts Ulaanbaatar. Nasopharyngeal swabs (n=6,545)...
BackgroundRecurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether bacille Calmette-Guérin (BCG) vaccine can attenuate sore recurrences through off-target immunomodulatory effects.MethodsIn this nested randomised controlled trial within multicentre, phase 3 BRACE trial, 6828 healthcare workers were 36 sites Australia, Netherlands, Spain, United Kingdom and Brazil, receive BCG-Denmark no BCG (1:1 ratio...
Abstract Non-pharmaceutical interventions (NPIs) implemented to contain SARS-CoV-2 have decreased invasive pneumococcal disease. We undertook an observational study evaluate the impact of NPIs on carriage and density, drivers transmission disease, during COVID-19 pandemic in Ho Chi Minh City, Vietnam. While did not significantly carriage, mean capsular density by up 91.5% (1.07 log 10 genome equivalents/mL, 95% Confidence Interval: 0.74-1.41) after NPI introduction compared with pre-COVID-19...