A5046705548- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Diet and metabolism studies
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Endoplasmic Reticulum Stress and Disease
- Digestive system and related health
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Probiotics and Fermented Foods
- Data-Driven Disease Surveillance
- Cardiovascular Disease and Adiposity
- Calcium signaling and nucleotide metabolism
- Kruppel-like factors research
- Influenza Virus Research Studies
Innsbruck Medical University
2016-2025
Universität Innsbruck
2015-2025
University Hospital Innsbruck
2019
Objective Alcoholic liver disease (ALD) is a global health problem with limited therapeutic options. Intestinal barrier integrity and the microbiota modulate susceptibility to ALD. Akkermansia muciniphila , Gram-negative intestinal commensal, promotes function partly by enhancing mucus production. The aim of this study was investigate microbial alterations in ALD define impact A. administration on course Design analysed an unbiased approach 16S ribosomal DNA (rDNA) sequencing Lieber-DeCarli...
Objective Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing rate-limiting step NAD salvage pathway . NAMPT strongly upregulated in inflammation including IBD and counteracts an increased turnover mediated by NAD-depleting enzymes. These constitute important mechanistic link between inflammatory, metabolic...
A cytokine storm conceivably contributes to manifestations of corona virus disease (COVID-19). Inflammatory cytokines such as interleukin-6 (IL-6) cause acute liver injury while serum detectability indicates systemic inflammation.
Background & AimsCrohn's disease (CD) globally emerges with Westernization of lifestyle and nutritional habits. However, a specific dietary constituent that comprehensively evokes gut inflammation in human inflammatory bowel diseases remains elusive. We aimed to delineate how increased intake polyunsaturated fatty acids (PUFAs) Western diet, known impart risk for developing CD, affects course. hypothesized the unfolded protein response antioxidative activity glutathione peroxidase 4 (GPX4),...
Alcohol-related liver disease (ALD) is a major cause of and represents global burden, as treatment options are scarce. Whereas 90% ethanol abusers develop alcoholic fatty (AFLD), only minority evolves to steatohepatitis cirrhosis. Alcohol increases lipogenesis suppresses lipid-oxidation implying steatosis, although the key role intestinal barrier integrity microbiota in ALD has recently emerged. Bacteroides thetaiotaomicron (Bt) prominent member human murine microbiota, plays important...
Introduction Metabolic-associated liver diseases have emerged pandemically across the globe and are clinically related to metabolic disorders such as obesity type 2 diabetes. The new nomenclature definition (i.e. dysfunction-associated steatotic disease – MASLD; steatohepatitis MASH) reflect nature of these complex systemic disorders, which characterized by inflammation, gut dysbiosis dysregulation. In this review, we summarize recent advantages in understanding pathophysiology MASLD,...
Background: HCC is the leading cause of cancer in chronic liver disease. A growing body experimental mouse models supports notion that gut-resident and liver-resident microbes control hepatic immune responses and, thereby, crucially contribute to tumorigenesis. However, a comprehensive characterization intestinal microbiome fueling transition from disease humans currently missing. Methods: Here, we profiled fecal, blood, tissue patients with by 16S rRNA sequencing compared profiles...
Low-grade chronic inflammation emerges as a potent driver of insulin resistance and glucose dysregulation in obesity associated non-alcoholic fatty liver disease (NAFLD). The liver, subcutaneous fat the immune system participate disturbances metabolism. Type I interferon (IFN) signalling initiated by innate adaptive immunity modulates inflammatory responses consequent to infection. However, little is known about role type IFN metabolic diseases development NAFLD.We determined impact...
Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) profibrotic, proinflammatory cytokine with increasingly recognised toxicities in parenchymal epithelial cells. We explored IL-11 serum levels their prognostic value patients suffering from AH cirrhosis various aetiology experimental ALD.
Abstract Background The rising incidence of Crohn’s disease (CD) is paralleled by a Westernization diet including an increased consumption long-chain polyunsaturated fatty acids (PUFA). Previous research demonstrated that PUFA positively correlated with clinical activity in CD patients1 and mice lacking antioxidant GPX4 their intestinal epithelial cells develop like enteritis when fed enriched Western diet2. In this study we investigated whether blocking signalling through the receptor RXRα...
The translocation of bacterial components from the intestinal lumen into portal circulation is crucial in pathogenesis alcoholic liver disease (ALD). Recently important role gut vascular barrier (GVB) was elucidated disease. Here we report about influence A. muciniphila supplementation experimental ALD on GVB. Ethanol feeding associated with increased Pv-1, indicating altered endothelial function, whereas administration tended to restore To further investigate GVB ALD, β-catenin...
Severe liver damage is associated with worse outcome in COVID-19. Our aim was to explore the degree of damage, stiffness (LS) and severity illness patients COVID-19.We investigated 32 COVID-19 admitted University Hospital Innsbruck a prospective cross-sectional study. We performed laboratory testing, spleen sonography elastography measure organ stiffness.12 (38%) showed elevated aminotransferases gamma-glutamyltransferase levels. LS positively correlated aminotransferase levels compared...
Abstract Background & Aims Alcohol‐related liver disease (ALD) comprises different disorders which impose a health care issue. ALD and particularly alcoholic steatohepatitis, an acute inflammatory condition, cause substantial morbidity mortality as effective treatment options remain elusive. Inflammation in is fuelled by macrophages (Kupffer cells [KCs]) are activated intestinal pathogen associated molecular patterns, eg lipopolysaccharide (LPS), disseminated beyond defective barrier. We...
Chronic alcohol consumption and alcoholic liver disease (ALD) afflicts individuals with substantial morbidity mortality limited treatment options available. Hepatic inflammation, triggered by activated Kupffer cells, is a driving force in disease. Interleukin 37 (IL-37) exerts anti-inflammatory effects hepatic diseases, however, the impact of on unknown. In this study, we addressed role We utilized expressing transgenic mice human recombinant models expression was measured samples 20...
Introduction . Obesity and related nonalcoholic fatty liver disease (NAFLD) are an emerging health care issue that imposes substantial morbidity to individuals. Growth differentiation factor 15 ( GDF15 ) limits food uptake, body weight, energy balance by modulation of GDNF-family receptor α -like (GFRAL) signalling in the hindbrain. However, regulation expression obesity NAFLD is incompletely understood. We sought define impact weight loss achieved laparoscopic adjustable gastric banding...