A5002744002- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Aortic aneurysm repair treatments
- Forensic Toxicology and Drug Analysis
- Aortic Disease and Treatment Approaches
- Fatty Acid Research and Health
- Crystal structures of chemical compounds
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Connective tissue disorders research
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Alcoholism and Thiamine Deficiency
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Gut microbiota and health
Innsbruck Medical University
2014-2022
Universität Innsbruck
2015-2022
Management Center Innsbruck
2015
Roche (Switzerland)
2012
Objective Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing rate-limiting step NAD salvage pathway . NAMPT strongly upregulated in inflammation including IBD and counteracts an increased turnover mediated by NAD-depleting enzymes. These constitute important mechanistic link between inflammatory, metabolic...
Crystal structure prediction studies indicated the existence of an unknown high density monohydrate (
Abstract Background The increasing relevance of individual bile acids quantification in biological samples requires analytical standardization to guarantee robustness and reliability laboratory results. We have organized the first international ring trial, carried out 12 laboratories, evaluate newly developed LC-MS/MS–based test kit for acid analysis. Methods Each received a Biocrates® Bile Acids Kit including system suitability (SST) protocol. is designed analyze 16 human 19 mouse acids. A...
Our basic understanding of ascending thoracic aortic aneurysm (ATAA) pathogenesis is still very limited, hampering early diagnosis, risk prediction, and development treatment options. "Omics"-technologies, ideal to reveal tissue alterations from the normal physiological state due disease have hardly been applied in field. Using a metabolomic approach, with this study authors seek define differences between controls various forms ATAAs.Using targeted FIA-MS/MS metabolomics we analysed...
Tryptophan (TRP) catabolism via the kynurenine pathway is considered to represent a major link between inflammation and various diseases, including neurodegenerative disorders, depression, schizophrenia, multiple sclerosis, cardiovascular disease, cancer. The levels of TRP its metabolites (KYN), kynurenic acid (KYNA) quinolinic (QUIN) are well regulated under physiological conditions but may be altered as part activated immune response. A simple, sensitive, specific liquid...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central nervous system. The use biological fluids in AD diagnosis remains limited to analysis specific protein biomarkers cerebrospinal fluid. However, metabolomic has recently revealed several metabolites plasma, especially phosphatidylcholines (PC), as putative for AD. Following on previous reports platelet abnormalities AD, we hypothesized that platelets released plasma may offer new aim present study was apply...
Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via receptors or intrinsic pathways.BIRC4/XIAP is the most potent anti-apoptotic IAP-member it physically interacts its BIR2 BIR3 domain.These domains also critical for interaction mitochondria-derived SMAC/Diablo IAP protein survivin.Survivin frequently overexpressed in neuroblastoma due to a gain 17q we have demonstrated survivin confers resistance chemotherapeutic...
The health benefit through the control of lipid levels in hyperlipidaemic individuals is evident from a large number studies. pharmacological options to achieve this goal shall be as specific and personalized reasons for co-factors hyperlipidaemia. It was study reveal impact leoligin on cholesterol define its mechanism action. Oral application ApoE-/- mice led significantly reduced total serum reduction postprandial blood glucose peak levels. In absence biochemical signs toxicity, treatment...
Recent research has suggested that excessive alcohol consumption in patients with use disorder (AUD) is associated chronic immune activation, which affects the metabolism of neurotransmitter precursor amino acid tryptophan (TRP) and contributes to complex pathophysiology AUD. Our study investigated possible immune-associated alterations TRP kynurenine (KYN) AUD during acute withdrawal.We measured serum concentrations TRP, KYN, quinolinic (QUIN), kynurenic (KYNA), activation marker neopterin...
Forensic toxicology and environmental water analysis share the common interest responsibility in ensuring comprehensive reliable confirmation of drugs pharmaceutical compounds samples analyzed. Dealing with similar analytes, detection identification techniques should be exchangeable between scientific disciplines. Herein, we demonstrate successful adaption a forensic toxicological screening workflow employing nontargeted LC/MS/MS under data-dependent acquisition control subsequent database...
Acute and chronic mental stress are both linked to somatic psychiatric morbidity, however, the neurobiological pathways of these associations still not fully elucidated. Mental is known be immunomodulatory, which one basic concepts psychoneuroimmunology. In present study, neurotransmitter precursor amino acid levels derived biogenic amines were analyzed prior at 0, 30 60 minutes following an acute test (with/without stress) in 53 healthy subjects. Psychometric measurements stress, depression...