A5066128224- Congenital heart defects research
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Electrospun Nanofibers in Biomedical Applications
- Magnesium Alloys: Properties and Applications
- Photochromic and Fluorescence Chemistry
- Genomics and Chromatin Dynamics
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
Universität Ulm
2015-2025
Jawaharlal Nehru Centre for Advanced Scientific Research
2012
Zebrafish can efficiently regenerate their heart through cardiomyocyte proliferation. In contrast, mammalian cardiomyocytes stop proliferating shortly after birth, limiting the regenerative capacity of postnatal heart. Therefore, if endogenous potential proliferation could be enhanced, it offer a promising future therapy for failure patients. Here, we set out to systematically identify small molecules triggering By screening chemical compound libraries utilizing Fucci-based system assessing...
Abstract In contrast to mammals, adult zebrafish achieve complete heart regeneration via proliferation of cardiomyocytes. Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue during aging in mammals. Pharmacological inhibition ATM and ATR kinases revealed damage response signaling is essential regeneration. Manipulation Bone Morphogenetic Protein (BMP)-Smad using transgenics mutants showed BMP alleviates...
In contrast to mammals, the zebrafish maintains its cardiomyocyte proliferation capacity throughout adulthood. However, neither molecular mechanisms that orchestrate of cardiomyocytes during developmental heart growth nor in context regeneration adult are sufficiently defined yet. We identified a forward genetic N-ethyl-N-nitrosourea (ENU) mutagenesis screen recessive, embryonic-lethal mutant baldrian ( bal ), which shows severely impaired due diminished proliferation. By positional cloning,...
Journal Article Inhibition of acetyltransferase alters different histone modifications: probed by small molecule inhibitor plumbagin Get access Mohankrishna Dalvoy Vasudevarao, Vasudevarao Transcription and Disease Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore-560064, India Search other works this author on: Oxford Academic PubMed Google Scholar Karthigeyan Dhanasekaran, Dhanasekaran Ruthrotha B. Selvi, Selvi Tapas K. Kundu * *Tapas Kundu, Lab,...
Abstract One hallmark of aging is a decline in tissue regeneration, which can be caused by DNA replication stress. Whether highly regenerative species like zebrafish are immune from such hindrances to unknown. In contrast most mammals, adult achieve complete heart regeneration via cell cycle entry and proliferation mature cardiomyocytes. We found that cycling cardiomyocytes experience stress, induced the demands but does not occur during physiological growth. Since cardiomyocyte remarkably...
Abstract Adult zebrafish are frequently described to be able “completely” regenerate the heart. Yet, extent which cardiomyocytes lost injury replaced is unknown, since only indirect or non-quantitative evidence for cardiomyocyte proliferation exists. We established stereological methods quantify number of at several time-points post cryoinjury. Intriguingly, after cryoinjuries that killed about 1/3 ventricular cardiomyocytes, pre-injury numbers were restored already within 30 days. many...