A5090184431- Axon Guidance and Neuronal Signaling
- Congenital heart defects research
- Medicinal Plants and Bioactive Compounds
- Nerve injury and regeneration
- Multiple Sclerosis Research Studies
- Magnesium Alloys: Properties and Applications
- Tissue Engineering and Regenerative Medicine
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Neural Networks and Applications
- Exercise and Physiological Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Memory Processes and Influences
- Developmental Biology and Gene Regulation
- Apelin-related biomedical research
- Ultrasound and Hyperthermia Applications
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Effects of Radiation Exposure
Universität Ulm
2019-2025
Isfahan University of Medical Sciences
2024
Abstract In contrast to mammals, adult zebrafish achieve complete heart regeneration via proliferation of cardiomyocytes. Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue during aging in mammals. Pharmacological inhibition ATM and ATR kinases revealed damage response signaling is essential regeneration. Manipulation Bone Morphogenetic Protein (BMP)-Smad using transgenics mutants showed BMP alleviates...
Successful regeneration requires the coordinated execution of multiple cellular responses to injury. In amputated zebrafish fins, mature osteoblasts dedifferentiate, migrate towards injury, and form proliferative osteogenic blastema cells. We show that osteoblast migration is preceded by cell elongation alignment along proximodistal axis, which require actomyosin, but not microtubule (MT) turnover. Surprisingly, dedifferentiation can be uncoupled. Using pharmacological genetic interventions,...
Abstract Purpose One of the most frequent complications associated with diabetes mellitus is apoptosis within brain which can lead to cognitive disorders. Exercise considered best non‐pharmacological approach reduce severity and extent cell death through poorly‐understood mechanisms. The aim this study was investigate effects voluntary complex regular wheel running on levels 8‐oxoguanine DNA glycosylase (OGG 1 ), semaphorin 3B (sema3B), hydrogen peroxide (H 2 O in hippocampus diabetic rats....
Abstract One hallmark of aging is a decline in tissue regeneration, which can be caused by DNA replication stress. Whether highly regenerative species like zebrafish are immune from such hindrances to unknown. In contrast most mammals, adult achieve complete heart regeneration via cell cycle entry and proliferation mature cardiomyocytes. We found that cycling cardiomyocytes experience stress, induced the demands but does not occur during physiological growth. Since cardiomyocyte remarkably...
Acquiring new knowledge necessitates alterations at the synaptic level within brain. Glutamate, a pivotal neurotransmitter, plays critical role in these processes, particularly learning and memory formation. Although previous research has explored glutamate's involvement cognitive functions, comprehensive understanding of its real-time dynamics remains elusive during tasks.
Experimental Autoimmune Encephalomyelitis (EAE) is an appropriate model for investigating the inflammation indices in Multiple Sclerosis (MS). The aim of this study was to evaluate pretreatment effect 6-week forced swimming exercise alongside vitamin D supplementation on levels cytokines and brain-derived neurotrophic factor (BDNF) rats with EAE. Swimming performed 5 d/week over a period 6 weeks. training program initiated 30 minutes first week then by adding min daily it reached 60 second...